Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors?

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Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors?

Chinese Medical Sciences Journal Vol. 36, Issue 4, Pages: 284-294(2021)

Original Articles | Updated：2024-04-10

|

- Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors?
- Affiliations：
  
  Department of General Surgery, Peking University Third Hospital, Beijing 100191, China
- Author bio：
  
  *Hangyan Wang, E-mail: wanghangyan111@163.com;
  Chunhui Yuan, Tel: 86-10-82267321, Fax: 86-10-62010334, E-mail: yuanchunhui1971@163.com;
  Dianrong Xiu, Tel: 86-10-82267320, Fax: 86-10-62010334, E-mail: xiudianrong1964@163.com
- Funds：
- DOI：10.24920/003803
  CLC：
- Received：09 July 2020，
  
  Published Online：08 October 2021，
  
  Published：31 December 2021
- Accepted：
Scan QR Code
Wang Liang, Li Gang, Bing Yun-tao, et al. Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors?[J]. Chinese medical sciences journal, 2021, 36(4): 284-294.
DOI：

Wang Liang, Li Gang, Bing Yun-tao, et al. Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors?[J]. Chinese medical sciences journal, 2021, 36(4): 284-294. DOI： 10.24920/003803.

摘要

目的

探讨既往非胰腺来源的恶性肿瘤对局限性胰腺神经内分泌肿瘤（PanNET）患者生存结局的影响。

方法

我们选取美国肿瘤监测、流行病学和生存结果数据库（the Surveillance

Epidemiology

and End Results database

SEER database）中

1973年至2015年期间诊断为局部PanNET的患者进行研究。根据患者既往是否存在非胰腺恶性肿瘤

我们将患者分为两组。在倾向评分匹配前和匹配后

我们比较了两组患者的临床病理特征

并研究了总体生存率和癌症特异性生存率的独立影响因素。

结果

在2778例局限性PanNET患者中

357例（12.9%）既往曾患有癌症。在2778例患者中

数据资料完整的患者有1344例

其中既往无肿瘤病史的患者1211例

合并肿瘤病史的患者133例。分析发现

既往患有癌症与高龄（65岁以上

57.9%既往患有癌症

31.0%既往无癌症

P

<

0.001）、诊断年份较晚（87.2%比80.2%

P

=0.049）、低分化/未分化级别肿瘤比例较高（4.5%比1.5%

P

=0.025）和既往肿瘤未手术比例较高（19.5%比10.4%

P

=0.003）相关。前列腺癌（29.32%）、乳腺癌（18.05%）、其他泌尿生殖道癌和腹膜后癌（16.54%）以及胃肠道癌（12.78%）是最常见的既往癌症类型。大多数既往癌症（95.49%）为局限性或区域性肿瘤

只有4.51%的患者既往癌症伴远处转移。两个肿瘤发病间隔时间≤36个月、36-60个月、60-120个月和

>

120个月分别占33.08%、13.53%、24.06%和29.32%。在对两组患者变量进行倾向评分匹配前和匹配后

我们对患者进行了单变量和多变量Cox比例风险分析

结果显示匹配前和匹配后

既往癌症的存在与否并不影响局部PanNET患者的生存结果。进一步亚组分析显示

既往合并转移癌症的患者PanNET特异性生存率比既往局部或区域癌症的患者或既往无癌症的患者生存率低。既往癌症的部位和两种肿瘤的间隔期不影响患者的生存率。

结论

具有既往癌症史的局限性PanNET患者的生存结果与无既往癌症史的患者相当。如果其他条件相同

则具有既往癌症史的局限性PanNET患者可以作为临床试验的候选患者。此研究结果支持为此类患者的PanNET提供更为积极的治疗方法。

Abstract

Objective

To investigate the impact of prior non-pancreatic cancer on the survival outcomes of patients with localized pancreatic neuroendocrine tumors (PanNETs).

Methods

We reviewed the Surveillance

Epidemiology

and End Results database and selected patients with localized PanNETs diagnosed between 1973 and 2015. We divided the patients into two groups according to the presence or absence of prior non-pancreatic malignancy. Before and after propensity score matching

we compared the clinicopathological characteristics and studied the overall survival and cancer-specific survival.

Results

A total of 357 (12.9%) of 2778 patients with localized PanNETs had prior cancer. A total of 1211 cases with only a localized PanNET and 133 cases with a localized PanNET and prior cancer had complete data and met the inclusion criteria of the current study. Patients with prior cancer were associated with advanced age (

>

65 years

57.9% prior cancer

vs

. 31.0% no prior cancer

P

<

0.001)

later year of diagnosis (87.2%

vs

. 80.2%

P

=0.049)

a higher proportion of poorly differentiated/undifferentiated grade tumors (4.5%

vs

. 1.5%

P

=0.025)

and a higher proportion of no primary site surgery (19.5%

vs

. 10.4%

P

=0.003). Prostate (29.32%)

breast (18.05%)

other genitourinary and retroperitoneal (16.54%)

and gastrointestinal (12.78%) cancers were the most common prior cancer types. Most of the prior cancers (95.49%) were localized and regional

and only 4.51% of the prior cancers were distant. Patients with interval periods between the prior cancer and PanNET of ≤36 months

36-60 months

60-120 months

and

>

120 months accounted for 33.08%

13.53%

24.06%

and 29.32% of all cases with prior cancers

respectively. Univariate and multivariate

Cox

proportional hazards analyses were performed. The presence/absence of prior cancers did not impact survival outcomes of patients with localized PanNETs before and after propensity score matching (PSM). Further subgroups analysis showed that

patients with localized PanNETs and prior distant cancer had worse cancer-specific survival than patients with prior local/regional cancer or patients without prior cancer (

P

<

0.001). No significant differences in cancer-specific survival were observed in terms of the different sites of the prior cancers and the different interval periods of prior cancers and PanNETs (

P

<

0.05).

Conclusions

Patients with localized PanNETs and a history of prior cancer had survival outcomes that were comparable to those of patients with no history of prior cancer. Patients with localized PanNETs and prior cancer could be candidates for clinical trials if they satisfy all other conditions; aggressive and potentially curative therapies should be offered to these patients.

关键词

Keywords

references

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