Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity

Zhang Xue; Xu Yan; Pei Lijian

doi:10.24920/003859

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Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity

Chinese Medical Sciences Journal Vol. 36, Issue 4, Pages: 316-322(2021)

Reviews | Updated：2024-04-10

- Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity
- Affiliations：
  
  1. 1Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  2. 2Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  *Tel: 86-18612672127, E-mail: hazelbeijing@vip.163.com
- Funds：
- DOI：10.24920/003859
  CLC：
- Received：30 November 2020，
  
  Published Online：08 November 2021，
  
  Published：31 December 2021
- Accepted：
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Zhang Xue, Xu Yan, Pei Lijian. Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity[J]. Chinese medical sciences journal, 2021, 36(4): 316-322.
DOI：

Zhang Xue, Xu Yan, Pei Lijian. Review of Neuromyelitis Optica Spectrum Disorder with Pain-Depression Comorbidity[J]. Chinese medical sciences journal, 2021, 36(4): 316-322. DOI： 10.24920/003859.

摘要

视神经脊髓炎谱系疾病是一种中枢神经系统炎性疾病

主要累及视神经及脊髓

在亚洲人群中发病率显著高于世界其他地区。80%以上视神经脊髓炎谱系疾病患者合并疼痛症状

其中痛性痉挛及神经病理性疼痛最具特点。抑郁常与疼痛共存

严重影响患者生活质量。近年来

很多研究发现疼痛与抑郁在机制上存在重叠

然而两者之间的联系仍不明确。本文对视神经脊髓炎谱系疾病患者合并疼痛抑郁共病的流行病学特征、发病机制及诊断治疗进行综述。

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disorder of the central nervous system predominantly targeting optic nerves and the spinal cord. The prevalence of the disease is much higher in Asia than in other parts of the world. Pain can be detected in more than 80% of NMOSD patients

with evoked pain mostly being caused by painful tonic muscle spasms and neuropathic pain as the most characteristic types. Depression is often comorbid with pain

and their comorbidity can severely influence quality of life. In recent years

studies have found considerable overlaps between the mechanisms of pain and depression; however

their association remains unclear. This article reviews the epidemiology

mechanism

evaluation and treatment of pain-depression comorbidity in NMOSD patients.

关键词

Keywords

references

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