Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation

Yang Qiwen; Ma Xiaoling; Hu Fupin; Zhang Jing; Sun Tongwen; Chen Baiyi; Xu Yingchun; Liu Youning; China Medical Education Association; Expert Committee on Infectious Diseases, China Medical Education Association

doi:10.24920/003864

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Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation

Chinese Medical Sciences Journal Vol. 36, Issue 1, Pages: 1-16(2021)

Guideline & Consensus | Updated：2024-04-10

- Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation
- Affiliations：
  
  1. 1Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  2. 2Department of Laboratory Medicine, the First Affiliated Hospital, University of Science and Technology of China, Hefei 230001, China
  3Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
  4General ICU, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
  5Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang 110001, China
  6Department of Respiratory Medicine, the First Medical Center of PLA General Hospital, Beijing 100853, China
- Author bio：
  
  *Yingchun Xu, Tel: 86-10-69159766, E-mail: xycpumch@139.com;
  Youning Liu, Tel: 86-10-66939114, E-mail: liuyn301@126.com
- Funds：
- DOI：10.24920/003864
  CLC：
- Received：10 December 2020，
  
  Accepted：2020-12-14，
  
  Published Online：14 January 2021，
  
  Published：14 January 2021
- Accepted：
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Yang Qiwen, Ma Xiaoling, Hu Fupin, et al. Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation[J]. Chinese medical sciences journal, 2021, 36(1): 1-16.
DOI：

Yang Qiwen, Ma Xiaoling, Hu Fupin, et al. Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation[J]. Chinese medical sciences journal, 2021, 36(1): 1-16. DOI： 10.24920/003864.

摘要

Abstract

The polymyxins are important antimicrobial agents against antibiotic-resistant gram-negative bacilli. In 2020

the Clinical and Laboratory Standards Institute modified the clinical breakpoints for polymyxin susceptibility test by eliminating the “susceptible” interpretive category

only reporting intermediate (≤2 mg/L) and resistant (≥4 mg/L). However

the European Committee on Antimicrobial Susceptibility Testing recommended the use of clinical breakpoints of ≤2 mg/L as susceptible and >2 mg/L as resistant. The first-line laboratorians and clinicians in China have been perplexed by the inconsistence of international polymyxin clinical breakpoints and discouraged by the difficulty of conducting polymyxin susceptibility testing. Therefore

it is urgently needed to make it clear for the laboratorians in China to know how to accurately carry out polymyxin susceptibility testing and standardize the interpretation of susceptibility testing results. To this end

the experts from relevant fields were convened to formulate this consensus statement on the testing and clinical interpretation of polymyxin susceptibility. Relevant recommendations are proposed accordingly for laboratorians and clinicians to streamline their daily work.

关键词

Keywords

references

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