Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease

Nana Zhang; Zijian Li; Haibo Zhu

doi:10.24920/003936

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Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease

Chinese Medical Sciences Journal Vol. 37, Issue 3, Pages: 275-281(2022)

Review | Updated：2024-04-10

- Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease
- Affiliations：
  
  1. 1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100050, China
  2. 2Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100050, China
  3. 3State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
- Author bio：
- Funds：
- DOI：10.24920/003936
  CLC：
- Received：16 May 2021，
  
  Accepted：2022-1-23，
  
  Published Online：26 June 2022，
  
  Published：30 September 2022
- Accepted：
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Nana Zhang, Zijian Li, Haibo Zhu. Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease[J]. Chinese medical sciences journal, 2022, 37(3): 275-281.
DOI：

Nana Zhang, Zijian Li, Haibo Zhu. Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease[J]. Chinese medical sciences journal, 2022, 37(3): 275-281. DOI： 10.24920/003936.

摘要

心肌灌注显像在冠心病的诊断、预后和管理中具有重要价值。当前

血管扩张剂和肾上腺素剂是最常见的心肌负荷药物。然而

这些药物在部分病人中的应用有限制

并且有多种副反应。因而

有必要开发可以在更多病人中应用的心肌负荷药物。去甲乌药碱是一种β受体激动剂

被批准作为心肌负荷药物应用于心肌缺血的诊断。因其正性肌力作用

去甲乌药碱有望成为用于冠心病诊断的心肌灌注显像负荷药物。本综述总结了去甲乌药碱在心肌灌注显像中的应用

包括其作用机制、给药方式、有效性及安全性。

Abstract

Myocardial perfusion imaging (MPI) is valuable for the diagnosis

prognosis

and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However

these agents have contraindications and may cause adverse effects in some patients. Thus

other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI

including its mechanism of action

stress protocol

efficacy

and safety.

关键词

Keywords

references

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