Dual Role of Wnt5a in the Progression of Inflammatory Diseases

Xu Chen; Hongling Liu; Dehong Li; Jinsui Wang; Fenghui Zhao

doi:10.24920/003994

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Dual Role of Wnt5a in the Progression of Inflammatory Diseases

Chinese Medical Sciences Journal Vol. 37, Issue 3, Pages: 265-274(2022)

Review | Updated：2024-04-10

- Dual Role of Wnt5a in the Progression of Inflammatory Diseases
- Affiliations：
  
  1. 1Department of Pathology, Gansu Provincial Hospital, Lazhou 730000, China
  2. 2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
  3. 3Department of Clinical Laboratory, Gansu Provincial Hospital, Lanzhou 730000, China
- Author bio：
- Funds：
- DOI：10.24920/003994
  CLC：
- Received：09 September 2021，
  
  Accepted：2022-3-6，
  
  Published Online：11 May 2022，
  
  Published：30 September 2022
- Accepted：
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Xu Chen, Hongling Liu, Dehong Li, et al. Dual Role of Wnt5a in the Progression of Inflammatory Diseases[J]. Chinese medical sciences journal, 2022, 37(3): 265-274.
DOI：

Xu Chen, Hongling Liu, Dehong Li, et al. Dual Role of Wnt5a in the Progression of Inflammatory Diseases[J]. Chinese medical sciences journal, 2022, 37(3): 265-274. DOI： 10.24920/003994.

摘要

Wnt5a是一种分泌性的Wnt蛋白

在细胞通路及炎性疾病中扮演重要作用。

WNT5A

基因可编码形成Wnt5a长链蛋白和Wnt5a短链蛋白

这两种蛋白的形成取决于

WNT5A

基因启动子甲基化的部位

具有不同的功能。然而

WNT5A

基因启动子甲基化的机制目前仍然不清楚。在炎性疾病中

因为

WNT5A

基因甲基化的部位不同

Wnt5a具有抑制炎症和促进炎症的双面功能

这或许涉及Wnt5a蛋白不同的亚型。因此

Wnt5a蛋白的不同亚型或许是潜在的炎性疾病诊断标记

WNT5A

基因甲基化的具体机制也需要深入研究。

Abstract

Wnt5a is a secreted Wnt ligand that plays a critical role in cellular pathways and inflammatory diseases. The

WNT5A

gene encodes two protein isoforms

Wnt5a-long and Wnt5a-short

which differ based on different promoter methylation and have distinct functions. However

the mechanisms of the promoter methylation are unclear. Depending on the extent of promoter methylation

Wnt5a exerts both anti-inflammatory and pro-inflammatory effects in inflammatory diseases

which may be involved in different Wnt5a isoforms. Therefore

the Wnt5a isoforms may be potential diagnostic markers for inflammatory diseases and the mechanisms of the

WNT5A

gene promoter methylation need to be further investigated.

关键词

Keywords

references

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