Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report

Xin He; Jianping Ning; Hui Xu; Gong Xiao; Huixiang Yang; Weiyuan Wang; Xiaoying Wu; Hongling Yin; Xiaozhao Li

doi:10.24920/003999

Your Location：

Home >

Browse articles >

Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report

Chinese Medical Sciences Journal Vol. 37, Issue 4, Pages: 359-362(2022)

Case Report | Updated：2024-04-10

- Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report
- Affiliations：
  
  1. 1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China
  2. 2Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China
  3. 3Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China
- Author bio：
  
  * E-mail: Hongling Yin: Yhl99@yahoo.com.cn;
  Xiaozhao Li: Tel: 86-731-89753773, E-mail: lixiaozhao@csu.edu.cn
- Funds：
- DOI：10.24920/003999
  CLC：
- Received：13 September 2021，
  
  Accepted：2022-4-1，
  
  Published Online：28 June 2022，
  
  Published：31 December 2022
- Accepted：
Scan QR Code
Xin He, Jianping Ning, Hui Xu, et al. Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report[J]. Chinese medical sciences journal, 2022, 37(4): 359-362.
DOI：

Xin He, Jianping Ning, Hui Xu, et al. Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report[J]. Chinese medical sciences journal, 2022, 37(4): 359-362. DOI： 10.24920/003999.

摘要

临床上继发于抗中性粒细胞胞浆抗体（anti-neutrophil cytoplasmic antibody，ANCA）相关血管炎的淀粉样蛋白A（amyloid A，AA）型淀粉样变性病例十分罕见。我们收治了1例77岁的ANCA相关血管炎女性患者。经活检取肾组织标本，Masson三色染色提示寡免疫复合物型新月体性肾小球炎；在电子显微镜下观察可见肾小球系膜区淀粉样物质沉积；免疫荧光染色显示λ轻链和κ轻链染色阴性。骨髓活组织检查未见浆细胞异常增生。最终，我们做出ANCA相关血管炎多血管炎继发AA型淀粉样变的诊断。

Abstract

Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here

we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis

and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally

she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.

关键词

Keywords

references

Cornec D , Cornec-Le Gall E , Fervenza FC , et al . ANCA-associated vasculitis—clinical utility of using ANCA specificity to classify patients . Nat Rev Rheumatol 2016 ; 12 ( 10 ): 570 - 9 . doi: 10.1038/nrrheum.2016.123 https://dx.doi.org/10.1038/nrrheum.2016.123 . DOI: 10.1038/nrrheum.2016.123 http://doi.org/10.1038/nrrheum.2016.123

Hilhorst M , van Paassen P , Tervaert JW , et al . Proteinase 3-ANCA vasculitis versus myeloperoxidase-ANCA vasculitis . J Am Soc Nephrol 2015 ; 26 ( 10 ): 2314 - 27 . doi: 10.1681/ASN.2014090903 https://dx.doi.org/10.1681/ASN.2014090903 . DOI: 10.1681/ASN.2014090903 http://doi.org/10.1681/ASN.2014090903

Westermark GT , Fandrich M , Westermark P . AA amyloidosis: pathogenesis and targeted therapy . Annu Rev Pathol 2015 ; 10 : 321 - 44 . doi: 10.1146/annurev-pathol-020712-163913 https://dx.doi.org/10.1146/annurev-pathol-020712-163913 . DOI: 10.1146/annurev-pathol-020712-163913 http://doi.org/10.1146/annurev-pathol-020712-163913

Papa R , Lachmann HJ . Secondary, AA, amyloidosis . Rheum Dis Clin North Am 2018 ; 44 ( 4 ): 585 - 603 . doi: 10.1016/j.rdc.2018.06.004 https://dx.doi.org/10.1016/j.rdc.2018.06.004 . DOI: 10.1016/j.rdc.2018.06.004 http://doi.org/10.1016/j.rdc.2018.06.004 https://linkinghub.elsevier.com/retrieve/pii/S0889857X18300577 https://linkinghub.elsevier.com/retrieve/pii/S0889857X18300577

Brunger A , Nienhuis H , Bijzet J , et al . Causes of AA amyloidosis: a systematic review . Amyloid 2020 ; 27 ( 1 ): 1 - 12 . doi: 10.1080/13506129.2019.1693359 https://dx.doi.org/10.1080/13506129.2019.1693359 . DOI: 10.1080/13506129.2019.1693359 http://doi.org/10.1080/13506129.2019.1693359

Maamar M , Tazi-Mezalek Z , Harmouche H , et al . Churg-Strauss syndrome associated with AA amyloidosis: a case report . Pan Afr Med J 2012 ; 12 : 30 .

Ubara Y , Tagami T , Suwabe T , et al . Systemic AA-amyloidosis related to MPO-ANCA microscopic polyangiitis: a case report . Amyloid 2006 ; 13 ( 3 ): 178 - 83 . doi: 10.1080/13506120600876815 https://dx.doi.org/10.1080/13506120600876815 . DOI: 10.1080/13506120600876815 http://doi.org/10.1080/13506120600876815

Views

367

Downloads

CSCD

Alert me when the article has been cited

Submit

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰