Role of Cannabinoid CB<sub>1</sub> Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats

Kaveh Shahveisi; Seyedeh Marziyeh Hadi; Hamed Ghazvini; Mehdi Khodamoradi

doi:10.24920/004087

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Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats

Chinese Medical Sciences Journal Vol. 38, Issue 1, Pages: 29-37(2023)

Original Article | Updated：2024-03-30

- Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats
- Affiliations：
  
  1. 1Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851451, Iran
  2. 2Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran
  3. 3Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari 48175866, Iran
  4. 4Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari 48175866, Iran
  5. 5Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851451, Iran
- Author bio：
- Funds：
- DOI：10.24920/004087
  CLC：
- Received：21 March 2022，
  
  Accepted：2022-9-6，
  
  Published Online：01 March 2023，
  
  Published：31 March 2023
- Accepted：
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Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, et al. Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats[J]. Chinese medical sciences journal, 2023, 38(1): 29-37.
DOI：

Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, et al. Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats[J]. Chinese medical sciences journal, 2023, 38(1): 29-37. DOI： 10.24920/004087.

摘要

目的

探讨大麻素CB1受体（cannabinoid CB1 receptor，CB1R）的拮抗作用是否会影响慢性快速眼动（chronically rapid eye movement，CRM）睡眠剥夺（CRM sleep-deprived，RSD）大鼠的新物体识别（novel object recognition，NOR）记忆。

方法

采用多平台技术对动物进行为期7天的慢性部分RSD范式的识别记忆检查。CB

R拮抗剂利莫那班（1mg/kg或3mg/kg，腹腔内注射）在记忆获取采样前一小时、在记忆巩固采样后即时或在NOR记忆提取测试阶段前至少一小时进行注射。为实现记忆再巩固，在第二个采样阶段完成后即时注射利莫那班。

结果

RSD损害了NOR记忆的获取、巩固和提取，但不影响NOR记忆的再巩固。注射利莫那班不影响记忆的获取、巩固和再巩固；然而，它减轻了慢性RSD对NOR记忆提取造成的损害。

结论

这些发现以及我们之前的报告似乎表明，RSD可能因其持续时间不同而影响识别记忆的不同阶段。重要的是，CB1R似乎至少部分参与了慢性RSD对NOR记忆的提取，但与NOR记忆的获取、巩固和再巩固无关。

Abstract

Objective

We aimed to investigate whether antagonism of the cannabinoid CB

receptor (CB

R) could affect novel object recognition (NOR) memory in chronically rapid eye movement sleep-deprived (RSD) rats.

Methods

The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform technique. The CB

R antagonist rimonaba

nt (1 or 3 mg/kg

i.p.) was administered either at one hour prior to the sample phase for acquisition

or immediately after the sample phase for consolidation

or at one hour before the test phase for retrieval of NOR memory. For the reconsolidation task

rimonabant was administered immediately after the second sample phase.

Results

The RSD episode impaired acquisition

consolidation

and retrieval

but it did not affect the reconsolidation of NOR memory. Rimonabant administration did not affect acquisition

consolidation

and reconsolidation; however

it attenuated impairment of the retrieval of NOR memory induced by chronic RSD.

Conclusions

These findings

along with our previous report

would seem to suggest that RSD may affect different phases of recognition memory based on its duration. Importantly

it seems that the CB

R may

at least in part

be involved in the adverse effects of chronic RSD on the retrieval

but not in the acquisition

consolidation

and reconsolidation

of NOR memory.

关键词

Keywords

references

Antony JW , Schonauer M , Staresina BP , et al. Sleep spindles and memory reprocessing . Trends Neurosci 2019 ; 42 ( 1 ): 1 - 3 . doi: 10.1016/j.tins.2018.09.012 https://dx.doi.org/10.1016/j.tins.2018.09.012 . DOI: S0166-2236(18)30258-3 http://doi.org/S0166-2236(18)30258-3

Chambers AM . The role of sleep in cognitive processing: focusing on memory consolidation . Wiley Interdiscip Rev Cogn Sci 2017 ; 8 ( 3 ). doi: 10.1002/wcs.1433 https://dx.doi.org/10.1002/wcs.1433 . DOI: 10.1002/wcs.1433 http://doi.org/10.1002/wcs.1433

Dahl RE . Sleep and the developing brain . Sleep 2007 ; 30 ( 9 ): 1079 - 80 . doi: 10.1093/sleep/30.9.1079 https://dx.doi.org/10.1093/sleep/30.9.1079 . DOI: 10.1093/sleep/30.9.1079 http://doi.org/10.1093/sleep/30.9.1079

Peterson MJ , Benca RM . Sleep in mood disorders . Psychiatr Clin North Am 2006 ; 29 ( 4 ): 1009 - 32 . doi: 10.1016/j.psc.2006.09.003 https://dx.doi.org/10.1016/j.psc.2006.09.003 . DOI: 10.1016/j.psc.2006.09.003 http://doi.org/10.1016/j.psc.2006.09.003 https://linkinghub.elsevier.com/retrieve/pii/S0193953X06000803 https://linkinghub.elsevier.com/retrieve/pii/S0193953X06000803

Walker MP . The role of sleep in cognition and emotion . Ann N Y Acad Sci 2009 ; 1156 : 168 - 97 . doi: 10.1111/j.1749-6632.2009.04416.x https://dx.doi.org/10.1111/j.1749-6632.2009.04416.x . DOI: 10.1111/j.1749-6632.2009.04416.x http://doi.org/10.1111/j.1749-6632.2009.04416.x https://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04416.x https://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04416.x

Bendor D , Wilson MA . Biasing the content of hippocampal replay during sleep . Nat Neurosci 2012 ; 15 ( 10 ): 1439 - 44 . doi: 10.1038/nn.3203 https://dx.doi.org/10.1038/nn.3203 . DOI: 10.1038/nn.3203 http://doi.org/10.1038/nn.3203

Sara SJ . Retrieval and reconsolidation: toward a neurobiology of remembering . Learn Mem 2000 ; 7 ( 2 ): 73 - 84 . doi: 10.1101/lm.7.2.73 https://dx.doi.org/10.1101/lm.7.2.73 . DOI: 10.1101/lm.7.2.73 http://doi.org/10.1101/lm.7.2.73 http://learnmem.cshlp.org/lookup/doi/10.1101/lm.7.2.73 http://learnmem.cshlp.org/lookup/doi/10.1101/lm.7.2.73

Stickgold R , Walker MP . Memory consolidation and reconsolidation: what is the role of sleep? Trends Neurosci 2005 ; 28 ( 8 ): 408 - 15 . doi: 10.1016/j.tins.2005.06.004 https://dx.doi.org/10.1016/j.tins.2005.06.004 . DOI: 10.1016/j.tins.2005.06.004 http://doi.org/10.1016/j.tins.2005.06.004

Buzsaki G . Memory consolidation during sleep: a neurophysiological perspective . J Sleep Res 1998 ; 7 Suppl 1 : 17 - 23 . doi: 10.1046/j.1365-2869.7.s1.3.x https://dx.doi.org/10.1046/j.1365-2869.7.s1.3.x . DOI: 10.1046/j.1365-2869.7.s1.3.x http://doi.org/10.1046/j.1365-2869.7.s1.3.x http://doi.wiley.com/10.1046/j.1365-2869.7.s1.3.x http://doi.wiley.com/10.1046/j.1365-2869.7.s1.3.x

Winters BD , Huang YH , Dong Y , et al. Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex . Brain Res 2011 ; 1420 : 1 - 7 . doi: 10.1016/j.brainres.2011.08.078 https://dx.doi.org/10.1016/j.brainres.2011.08.078 . DOI: 10.1016/j.brainres.2011.08.078 http://doi.org/10.1016/j.brainres.2011.08.078

Babson KA , Sottile J , Morabito D . Cannabis, cannabinoids, and sleep: a review of the literature . Curr Psychiatry Rep 2017 ; 19 ( 4 ): 23 . doi: 10.1007/s11920-017-0775-9 https://dx.doi.org/10.1007/s11920-017-0775-9 . DOI: 10.1007/s11920-017-0775-9 http://doi.org/10.1007/s11920-017-0775-9 http://link.springer.com/10.1007/s11920-017-0775-9 http://link.springer.com/10.1007/s11920-017-0775-9

Hampson RE , Deadwyler SA . Role of cannabinoid receptors in memory storage . Neurobiol Dis 1998 ; 5 (6 Pt B): 474 - 82 . doi: 10.1006/nbdi.1998.0223 https://dx.doi.org/10.1006/nbdi.1998.0223 . DOI: 10.1006/nbdi.1998.0223 http://doi.org/10.1006/nbdi.1998.0223

Murillo-Rodriguez E . The role of the CB 1 receptor in the regulation of sleep . Prog Neuropsychopharmacol Biol Psychiatry 2008 ; 32 ( 6 ): 1420 - 27 . doi: 10.1016/j.pnpbp.2008.04.008 https://dx.doi.org/10.1016/j.pnpbp.2008.04.008 . DOI: 10.1016/j.pnpbp.2008.04.008 http://doi.org/10.1016/j.pnpbp.2008.04.008 https://linkinghub.elsevier.com/retrieve/pii/S0278584608001103 https://linkinghub.elsevier.com/retrieve/pii/S0278584608001103

Murillo-Rodriguez E . The modulatory role of endocannabinoids in sleep . Rev Neurol 2008 ; 46 ( 3 ): 160 - 6 . doi: 10.33588/rn.4603.2006616 https://dx.doi.org/10.33588/rn.4603.2006616 . DOI: 10.33588/rn.4603.2006616 http://doi.org/10.33588/rn.4603.2006616

De Vries TJ , Schoffelmeer AN . Cannabinoid CB 1 receptors control conditioned drug seeking . Trends Pharmacol Sci 2005 ; 26 ( 8 ): 420 - 6 . doi: 10.1016/j.tips.2005.06.002 https://dx.doi.org/10.1016/j.tips.2005.06.002 . DOI: 10.1016/j.tips.2005.06.002 http://doi.org/10.1016/j.tips.2005.06.002

Pertwee RG . Pharmacology of cannabinoid CB 1 and CB 2 receptors . Pharmacol Ther 1997 ; 74 ( 2 ): 129 - 80 . doi: 10.1016/S0163-7258(97)82001-3 https://dx.doi.org/10.1016/S0163-7258(97)82001-3 . DOI: 10.1016/S0163-7258(97)82001-3 http://doi.org/10.1016/S0163-7258(97)82001-3

Chen L , Tian S , Ke J . Rapid eye movement sleep deprivation disrupts consolidation but not reconsolidation of novel object recognition memory in rats . Neurosci Lett 2014 ; 563 : 12 - 16 . doi: 10.1016/j.neulet.2014.01.024 https://dx.doi.org/10.1016/j.neulet.2014.01.024 . DOI: 10.1016/j.neulet.2014.01.024 http://doi.org/10.1016/j.neulet.2014.01.024

Shahveisi K , Farnia V , Khazaie H , et al. Novel object recognition memory in REM sleep-deprived rats: Role of the cannabinoid CB 1 receptor . Behav Brain Res 2020 ; 381 : 112311 . doi: 10.1016/j.bbr.2019.112311 https://dx.doi.org/10.1016/j.bbr.2019.112311 . DOI: 10.1016/j.bbr.2019.112311 http://doi.org/10.1016/j.bbr.2019.112311

Akirav I , Maroun M . Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory . Cereb Cortex 2006 ; 16 ( 12 ): 1759 - 65 . doi: 10.1093/cercor/bhj114 https://dx.doi.org/10.1093/cercor/bhj114 . DOI: 10.1093/cercor/bhj114 http://doi.org/10.1093/cercor/bhj114 https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhj114 https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhj114

Barker GR , Bird F , Alexander V , et al. Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex . J Neurosci 2007 ; 27 ( 11 ): 2948 - 57 . doi: 10.1523/JNEUROSCI.5289-06.2007 https://dx.doi.org/10.1523/JNEUROSCI.5289-06.2007 . DOI: 10.1523/JNEUROSCI.5289-06.2007 http://doi.org/10.1523/JNEUROSCI.5289-06.2007

Ennaceur A , Delacour J . A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data . Behav Brain Res 1988 ; 31( 1 ): 47 - 59 . doi: 10.1016/0166-4328(88)90157-x https://dx.doi.org/10.1016/0166-4328(88)90157-x . DOI: 10.1016/0166-4328(88)90157-x http://doi.org/10.1016/0166-4328(88)90157-x

Palchykova S , Winsky-Sommerer R , Meerlo P , et al. Sleep deprivation impairs object recognition in mice . Neurobiol Learn Mem 2006 ; 85 ( 3 ): 263 - 71 . doi: 10.1016/j.nlm.2005.11.005 https://dx.doi.org/10.1016/j.nlm.2005.11.005 . DOI: 10.1016/j.nlm.2005.11.005 http://doi.org/10.1016/j.nlm.2005.11.005

Salari M , Sheibani V , Saadati H , et al. The compensatory effect of regular exercise on long-term memory impairment in sleep deprived female rats . Behav Processes 2015 ; 119 : 50 - 7 . doi: 10.1016/j.beproc.2015.06.014 https://dx.doi.org/10.1016/j.beproc.2015.06.014 . DOI: 10.1016/j.beproc.2015.06.014 http://doi.org/10.1016/j.beproc.2015.06.014 https://linkinghub.elsevier.com/retrieve/pii/S0376635715300024 https://linkinghub.elsevier.com/retrieve/pii/S0376635715300024

Shahveisi K , Abdoli N , Farnia V , et al. REM sleep deprivation before extinction or reinstatement alters methamphetamine reward memory via D1-like dopamine receptors . Pharmacol Biochem Behav 2022 ; 213 : 173319 . doi: 10.1016/j.pbb.2021.173319 https://dx.doi.org/10.1016/j.pbb.2021.173319 . DOI: 10.1016/j.pbb.2021.173319 http://doi.org/10.1016/j.pbb.2021.173319 https://linkinghub.elsevier.com/retrieve/pii/S0091305721002185 https://linkinghub.elsevier.com/retrieve/pii/S0091305721002185

Shahveisi K , Abdoli N , Khazaie H , et al. Maternal sleep deprivation affects extinction and reinstatement of methamphetamine reward memory in male offspring: Role of the D1-like and D2-like dopamine receptors . Brain Res 2022 ; 1792 : 148033 . doi: 10.1016/j.brainres.2022.148033 https://dx.doi.org/10.1016/j.brainres.2022.148033 . DOI: 10.1016/j.brainres.2022.148033 http://doi.org/10.1016/j.brainres.2022.148033 https://linkinghub.elsevier.com/retrieve/pii/S0006899322002578 https://linkinghub.elsevier.com/retrieve/pii/S0006899322002578

Shahveisi K , Khazaie H , Farnia V , et al. REM sleep deprivation impairs retrieval, but not reconsolidation, of methamphetamine reward memory in male rats . Pharmacol Biochem Behav 2019 : 172759 . doi: 10.1016/j.pbb.2019.172759 https://dx.doi.org/10.1016/j.pbb.2019.172759 . DOI: 10.1016/j.pbb.2019.172759 http://doi.org/10.1016/j.pbb.2019.172759

Novati A , Roman V , Cetin T , et al. Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats . Sleep 2008 ; 31 ( 11 ): 1579 - 85 . doi: 10.1093/sleep/31.11.1579 https://dx.doi.org/10.1093/sleep/31.11.1579 . DOI: 10.1093/sleep/31.11.1579 http://doi.org/10.1093/sleep/31.11.1579

Khodamoradi M , Tirgar F , Ghazvini H , et al. Role of the cannabinoid CB 1 receptor in methamphetamine-induced social and recognition memory impairment . Neurosci Lett 2022 ; 779 : 136634 . doi: 10.1016/j.neulet.2022.136634 https://dx.doi.org/10.1016/j.neulet.2022.136634 . DOI: 10.1016/j.neulet.2022.136634 http://doi.org/10.1016/j.neulet.2022.136634 https://linkinghub.elsevier.com/retrieve/pii/S0304394022001914 https://linkinghub.elsevier.com/retrieve/pii/S0304394022001914

Riedel G , Micheau J , Lam AG , et al. Reversible neural inactivation reveals hippocampal participation in several memory processes . Nat Neurosci 1999 ; 2 ( 10 ): 898 - 905 . doi: 10.1038/13202 https://dx.doi.org/10.1038/13202 . DOI: 10.1038/13202 http://doi.org/10.1038/13202

Steele RJ , Morris RG . Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5 . Hippocampus 1999 ; 9 ( 2 ): 118 - 36 . doi: 10.1002/(SICI)1098-1063(1999)9:2＜118::AID-HIPO4＞3.0.CO;2-8 https://dx.doi.org/10.1002/(SICI)1098-1063(1999)9:2＜118::AID-HIPO4＞3.0.CO;2-8 . DOI: 10.1002/(SICI)1098-1063(1999)9:2＜118::AID-HIPO4＞3.0.CO;2-8 http://doi.org/10.1002/(SICI)1098-1063(1999)9:2＜118::AID-HIPO4＞3.0.CO;2-8

Moser MB , Moser EI . Distributed encoding and retrieval of spatial memory in the hippocampus . J Neurosci 1998 ; 18 ( 18 ): 7535 - 42 . doi: 10.1523/JNEUROSCI.18-18-07535.1998 https://dx.doi.org/10.1523/JNEUROSCI.18-18-07535.1998 . DOI: 10.1523/JNEUROSCI.18-18-07535.1998 http://doi.org/10.1523/JNEUROSCI.18-18-07535.1998

Zhang J , Zhang L , Chang Y , et al. The endocannabinoid system contributes to memory deficits induced by rapid-eye-movement sleep deprivation in adolescent mice . Neuroscience 2020 ; 433 : 174 - 83 . doi: 10.1016/j.neuroscience.2020.03.016 https://dx.doi.org/10.1016/j.neuroscience.2020.03.016 . DOI: S0306-4522(20)30166-4 http://doi.org/S0306-4522(20)30166-4

McCoy JG , Christie MA , Kim Y , et al. Chronic sleep restriction impairs spatial memory in rats . Neuroreport 2013 ; 24 ( 2 ): 91 - 5 . doi: 10.1097/WNR.0b013e32835cd97a https://dx.doi.org/10.1097/WNR.0b013e32835cd97a . DOI: 10.1097/WNR.0b013e32835cd97a http://doi.org/10.1097/WNR.0b013e32835cd97a

Andersen ML , Ribeiro DA , Bergamaschi CT , et al. Distinct effects of acute and chronic sleep loss on DNA damage in rats . Prog Neuropsychopharmacol Biol Psychiatry 2009 ; 33 ( 3 ): 562 - 7 . doi: 10.1016/j.pnpbp.2009.02.014 https://dx.doi.org/10.1016/j.pnpbp.2009.02.014 . DOI: 10.1016/j.pnpbp.2009.02.014 http://doi.org/10.1016/j.pnpbp.2009.02.014 https://linkinghub.elsevier.com/retrieve/pii/S0278584609000530 https://linkinghub.elsevier.com/retrieve/pii/S0278584609000530

Reibaud M , Obinu MC , Ledent C , et al. Enhancement of memory in cannabinoid CB 1 receptor knock-out mice . Eur J Pharmacol 1999 ; 379 ( 1 ): R1 - 2 . doi: 10.1016/S0014-2999(99)00496-3 https://dx.doi.org/10.1016/S0014-2999(99)00496-3 . DOI: 10.1016/s0014-2999(99)00496-3 http://doi.org/10.1016/s0014-2999(99)00496-3

Ishikawa A , Kanayama Y , Matsumura H , et al. Selective rapid eye movement sleep deprivation impairs the maintenance of long-term potentiation in the rat hippocampus . Eur J Neurosci 2006 ; 24 ( 1 ): 243 - 8 . doi: 10.1111/j.1460-9568.2006.04874.x https://dx.doi.org/10.1111/j.1460-9568.2006.04874.x . DOI: 10.1111/j.1460-9568.2006.04874.x http://doi.org/10.1111/j.1460-9568.2006.04874.x

Bliss TV , Collingridge GL . A synaptic model of memory: long-term potentiation in the hippocampus . Nature 1993 ; 361 ( 6407 ): 31 - 9 . doi: 10.1038/361031a0 https://dx.doi.org/10.1038/361031a0 . DOI: 10.1038/361031a0 http://doi.org/10.1038/361031a0

Misner DL , Sullivan JM . Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA 1 neurons . J Neurosci 1999 ; 19 ( 16 ): 6795 - 805 . doi: 10.1523/JNEUROSCI.19-16-06795.1999 https://dx.doi.org/10.1523/JNEUROSCI.19-16-06795.1999 . DOI: 10.1523/JNEUROSCI.19-16-06795.1999 http://doi.org/10.1523/JNEUROSCI.19-16-06795.1999

Paton GS , Pertwee RG , Davies SN . Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice . Neuropharmacology 1998 ; 37 ( 9 ): 1123 - 30 . doi: 10.1016/S0028-3908(98)00096-3 https://dx.doi.org/10.1016/S0028-3908(98)00096-3 . DOI: 10.1016/s0028-3908(98)00096-3 http://doi.org/10.1016/s0028-3908(98)00096-3

Bohme GA , Laville M , Ledent C , et al. Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors . Neuroscience 2000 ; 95 ( 1 ): 5 - 7 . doi: 10.1016/S0306-4522(99)00483-2 https://dx.doi.org/10.1016/S0306-4522(99)00483-2 . DOI: 10.1016/S0306-4522(99)00483-2 http://doi.org/10.1016/S0306-4522(99)00483-2

de Oliveira Alvares L , Do-Monte FH . Understanding the dynamic and destiny of memories . Neurosci Biobehav Rev 2021 ; 125 : 592 - 607 . doi: 10.1016/j.neubiorev.2021.03.009 https://dx.doi.org/10.1016/j.neubiorev.2021.03.009 . DOI: 10.1016/j.neubiorev.2021.03.009 http://doi.org/10.1016/j.neubiorev.2021.03.009

Iordanova MD , Good M , Honey RC . Retrieval-mediated learning involving episodes requires synaptic plasticity in the hippocampus . J Neurosci 2011 ; 31 ( 19 ): 7156 - 62 . doi: 10.1523/JNEUROSCI.0295-11.2011 https://dx.doi.org/10.1523/JNEUROSCI.0295-11.2011 . DOI: 10.1523/JNEUROSCI.0295-11.2011 http://doi.org/10.1523/JNEUROSCI.0295-11.2011

Nader K , Einarsson EO . Memory reconsolidation: an update . Ann N Y Acad Sci 2010 ; 1191 : 27 - 41 . doi: 10.1111/j.1749-6632.2010.05443.x https://dx.doi.org/10.1111/j.1749-6632.2010.05443.x . DOI: 10.1111/j.1749-6632.2010.05443.x http://doi.org/10.1111/j.1749-6632.2010.05443.x http://blackwell-synergy.com/doi/abs/10.1111/nyas.2010.1191.issue-1 http://blackwell-synergy.com/doi/abs/10.1111/nyas.2010.1191.issue-1

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Role of Cannabinoid CB1 Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats

DOI：10.24920/004087

摘要

Abstract

关键词

Keywords

references

Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats