“In the field of esophageal cancer immunotherapy, researchers have identified over-expressed genes MUC13 and EPCAM as promising antigen targets or biomarkers. The study, which utilized bioinformatic methods such as enrichment analysis, protein-protein interaction (PPI) network, and survival analysis, also revealed that keratinization significantly impacts the pathogenesis of esophageal cancer. Additionally, genes ALDH3A1, C2, SLC6A1, and ZBTB7C may play crucial roles in the disease's development.”