Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report

Fatemeh Mashhadiabbas; Sanaz GholamiToghchi; Roohollah Safarpour

doi:10.24920/004159

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Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report

Chinese Medical Sciences Journal Vol. 38, Issue 2, Pages: 138-146(2023)

Review | Updated：2024-06-12

- Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report
- Affiliations：
  
  1. 1Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 1983969413, Iran
  2. 2Department of Oral and Maxillofacial Pathology, School of Dentistry, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran
- Author bio：
  
  *98-917-7737642, 98-663-3207826, E-mail: Safarpoor.r@lums.ac.ir,
- Funds：
- DOI：10.24920/004159
  CLC：
- Received：19 August 2022，
  
  Accepted：2023-03-14，
  
  Published Online：14 April 2023，
  
  Published：30 June 2023
- Accepted：
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Fatemeh Mashhadiabbas, Sanaz GholamiToghchi, Roohollah Safarpour. Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report[J]. Chinese medical sciences journal, 2023, 38(2): 138-146.
DOI：

Fatemeh Mashhadiabbas, Sanaz GholamiToghchi, Roohollah Safarpour. Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report[J]. Chinese medical sciences journal, 2023, 38(2): 138-146. DOI： 10.24920/004159.

摘要

Abstract

Central granular cell odontogenic tumors (CGCOTs) are rare

benign

slowly growing odontogenic neoplasms. Due to their uncertain histogenesis

CGCOTs are still not included as a distinct entity in the WHO classification (2017) of odontogenic tumors. We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female. Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin

and negatively expressed S-100 protein. Meanwhile

we searched PubMed

Google Scholar

and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT. The results showed that the granular cells of 28.6% cases were immunopositive for vimentin and CD68

and odontogenic epithelial cells were positive immunoreactivity for cytokeratin. These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.

关键词

Keywords

references

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