FOLLOWUS
1. 1Administration Office of Science and Technology Projects, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2. 2Institute of Medical Information, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China
3. 3Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Received:13 September 2022,
Accepted:2022-9-14,
Published Online:01 November 2022,
Published:30 September 2022
Scan QR Code
Taolian Yang, Hua Zhong, Wei Wang, et al. A Decade of Scientific and Technological Innovation at Chinese Academy of Medical Sciences & Peking Union Medical College: Retrospect and Prospect[J]. Chinese medical sciences journal, 2022, 37(3): 240-45.
Taolian Yang, Hua Zhong, Wei Wang, et al. A Decade of Scientific and Technological Innovation at Chinese Academy of Medical Sciences & Peking Union Medical College: Retrospect and Prospect[J]. Chinese medical sciences journal, 2022, 37(3): 240-45. DOI: 10.24920/004167.
本文从深化科技体制改革、优化科技创新生态方面重点梳理了中国医学科学院北京协和医学院(以下简称“院校”)在医学健康科技创新发展中的改革举措
初步总结了院校近十年来通过科技创新守卫人民健康、推进健康中国战略的亮点工作
主要展示了其在基础研究、疾病防治、医药技术等领域科技创新成果。这些科技成果的取得凸显了院校为实现医学科技自立自强、全面推进健康中国建设提供重要支撑
为我国医学科技事业发展做出重要贡献。
Focusing on the reform initiatives of Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC) in medical scientific and technological innovation from perspectives of deepening the reform and optimizing the ecosystem of science and technology innovation
this article summarizes the highlights of CAMS & PUMC’s efforts in safeguarding people’s health and promoting the Healthy China 2030 strategy through scientific and technological innovation in the fields including basic research
disease prevention and treatment
and medical technology in the past ten years. These achievements embody the endeavors and responsibility of CAMS & PUMC in realizing self-reliance and self-improvement of Chinese medical science and technology and highlight its contributions to the development of medical science and technology of China.
Chinse Academy of Medical Sciences . Science and Technology Evaluation Metrics . News overview . Available from: http://top100.imicams.ac.cn/news http://top100.imicams.ac.cn/news http://top100.imicams.ac.cn/news. Accessed: September 30, 2022 .
Wang C , Zhai XM , Zhang XQ , et al. Gene-edited babies: Chinese Academy of Medical Sciences’ response and action . The Lancet 2019 ; 393 ( 10166 ): 25 - 6 . doi: 10.1016/S0140-6736(18)33080-0 https://dx.doi.org/10.1016/S0140-6736(18)33080-0 . DOI: 10.1016/S0140-6736(18)33080-0 http://doi.org/10.1016/S0140-6736(18)33080-0
Chen K , Liu J , Liu SX , et al. Methyltransferase SETD2-mediated methylation of STAT1 is critical for interferon antiviral activity . Cell 2017 ; 170 ( 3 ): 492 - 506.e14 . doi: 10.1016/j.cell.2017.06.042 https://dx.doi.org/10.1016/j.cell.2017.06.042 . DOI: S0092-8674(17)30761-4 http://doi.org/S0092-8674(17)30761-4
Wang P , Xu JF , Wang YJ , et al. An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism . Science 2017 ; 358 ( 6366 ): 1051 - 5 . doi: 10.1126/science.aao0409 https://dx.doi.org/10.1126/science.aao0409 . DOI: 10.1126/science.aao0409 http://doi.org/10.1126/science.aao0409
Xu XQ , Xu J , Wu JC , et al. Phosphorylation-mediated IFN-γR2 membrane translocation is required to activate macrophage innate response . Cell 2018 ; 175 ( 5 ): 1336 - 51.e17 . doi: 10.1016/j.cell.2018.09.011 https://dx.doi.org/10.1016/j.cell.2018.09.011 . DOI: S0092-8674(18)31183-8 http://doi.org/S0092-8674(18)31183-8
Jiang MH , Zhang SK , Yang ZH , et al. Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response . Cell 2018 ; 173 ( 4 ): 906 - 19 . doi: 10.1016/j.cell.2018.03.064 https://dx.doi.org/10.1016/j.cell.2018.03.064 . DOI: S0092-8674(18)30396-9 http://doi.org/S0092-8674(18)30396-9
Han YM , Liu QY , Hou J , et al. Tumor-induced generation of splenic erythroblast-like Ter-Cells promotes tumor progression . Cell 2018 ; 173 ( 3 ): 634 - 48.e12 . doi: 10.1016/j.cell.2018.02.061 https://dx.doi.org/10.1016/j.cell.2018.02.061 . DOI: S0092-8674(18)30238-1 http://doi.org/S0092-8674(18)30238-1
Shen QC , Zhang Q , Shi Y , et al. Tet 2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation . Nature 2018 ; 554 ( 7690 ): 123 - 7 . doi: 10.1038/nature25434 https://dx.doi.org/10.1038/nature25434 . DOI: 10.1038/nature25434 http://doi.org/10.1038/nature25434 http://www.nature.com/articles/nature25434 http://www.nature.com/articles/nature25434
Liu Y , You YL , Lu ZK , et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication . Science 2019 ; 365 ( 6458 ): 1171 - 6 . doi: 10.1126/science.aax4468 https://dx.doi.org/10.1126/science.aax4468 . DOI: 10.1126/science.aax4468 http://doi.org/10.1126/science.aax4468
Wang L , Wen MY , Cao XT . Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses . Science 2019 ; 365 ( 6454 ): eaav075 . doi: 10.1126/science.aav0758 https://dx.doi.org/10.1126/science.aav0758 . DOI: 10.1126/science.aav0758 http://doi.org/10.1126/science.aav0758
Liu YY , Liang XY , Dong WQ , et al. Tumor-repopulating cells induce PD-1 expression in CD8+ T Cells by transferring kynurenine and AhR activation . Cancer Cell 2018 ; 33 ( 3 ): 480 - 94.e7 . doi: 10.1016/j.ccell.2018.02.005 https://dx.doi.org/10.1016/j.ccell.2018.02.005 . DOI: 10.1016/j.ccell.2018.02.005 http://doi.org/10.1016/j.ccell.2018.02.005 https://linkinghub.elsevier.com/retrieve/pii/S1535610818300588 https://linkinghub.elsevier.com/retrieve/pii/S1535610818300588
Liu YY , Fang YL , Chen XF , et al. Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome . Sci Immunol 2020 ; 5 ( 43 ): 1 - 13 . doi: 10.1126/sciimmunol.aax7969 https://dx.doi.org/10.1126/sciimmunol.aax7969 . DOI: 10.1126/sciimmunol.aax7969 http://doi.org/10.1126/sciimmunol.aax7969
Zhou J , Xu JY , Zhang LL , et al. Combined single-cell profiling of lncRNAs and functional screening reveals that H 19 is pivotal for embryonic hematopoietic stem cell development . Cell Stem Cell 2019 ; 24 ( 2 ): 285 - 98 . doi: 10.1016/j.stem.2018.11.023 https://dx.doi.org/10.1016/j.stem.2018.11.023 . DOI: S1934-5909(18)30559-9 http://doi.org/S1934-5909(18)30559-9
Dong F , Hao S , Zhang S , et al. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis . Nature Cell Biol 2020 ; 22 ( 6 ): 630 - 9 . doi: 10.1038/s41556-020-0512-1 https://dx.doi.org/10.1038/s41556-020-0512-1 . DOI: 10.1038/s41556-020-0512-1 http://doi.org/10.1038/s41556-020-0512-1 https://doi.org/10.1038/s41556-020-0512-1 https://doi.org/10.1038/s41556-020-0512-1
Wang FJ , He JH , Liu SQ , et al. Comprehensive RNA editome reveals that edited Azin 1 partners with DDX1 to enable hematopoietic stem cell differentiation . Blood 2021 ; 138 ( 20 ): 1939 - 52 . doi: 10.1182/blood.2021011314 https://dx.doi.org/10.1182/blood.2021011314 . DOI: 10.1182/blood.2021011314 http://doi.org/10.1182/blood.2021011314
Li RY , Di L , Li J , et al. A body map of somatic mutagenesis in morphologically normal human tissues . Nature 2021 ; 597 ( 7876 ): 398 - 403 . doi: 10.1038/s41586-021-03836-1 https://dx.doi.org/10.1038/s41586-021-03836-1 . DOI: 10.1038/s41586-021-03836-1 http://doi.org/10.1038/s41586-021-03836-1 https://doi.org/10.1038/s41586-021-03836-1 https://doi.org/10.1038/s41586-021-03836-1
Yang XL , Li JX , Hu DS , et al. Predicting the 10-year risks of atherosclerotic cardiovascular disease in Chinese population: the China-PAR project (Prediction for ASCVD Risk in China) . Circulation 2016 ; 134 ( 19 ): 1430 - 40 . doi: 10.1161/CIRCULATIONAHA.117.027318 https://dx.doi.org/10.1161/CIRCULATIONAHA.117.027318 . DOI: 10.1161/CIRCULATIONAHA.117.027318 http://doi.org/10.1161/CIRCULATIONAHA.117.027318
Lu XF , Liu ZY , Cui QM , et al. A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study . Eur Heart J 2022 ; 43 ( 18 ): 1702 -+. doi: 10.1093/eurheartj/ehac093 https://dx.doi.org/10.1093/eurheartj/ehac093 . DOI: 10.1093/eurheartj/ehac093 http://doi.org/10.1093/eurheartj/ehac093
Zhang WL , Zhang SY , Deng Y , et al. Trial of intensive blood-pressure control in older patients with hypertension . New Engl J Med 2021 ; 385 ( 9 ): 1268 - 79 . doi: 10.1056/NEJMoa2111437 https://dx.doi.org/10.1056/NEJMoa2111437 . DOI: 10.1056/NEJMoa2111437 http://doi.org/10.1056/NEJMoa2111437 http://www.nejm.org/doi/10.1056/NEJMoa2111437 http://www.nejm.org/doi/10.1056/NEJMoa2111437
Huang KY , Liang FC , Yang XL . Long term exposure to ambient fine particulate matter and incidence of stroke BMJ: Bri Med J 2020 ; 368 ( 8229 ): 59 . doi: 10.1136/bmj.16720 https://dx.doi.org/10.1136/bmj.16720 . DOI: 10.1136/bmj.16720 http://doi.org/10.1136/bmj.16720
Xu B , Tu SX , Song L , et al. Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial . Lancet 2021 ; 398 ( 10317 ): 2149 - 59 . doi: 10.1016/S0140-6736(21)02248-0 https://dx.doi.org/10.1016/S0140-6736(21)02248-0 . DOI: 10.1016/S0140-6736(21)02248-0 http://doi.org/10.1016/S0140-6736(21)02248-0
Xiao D , Chen ZM , Wu SN , et al. Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study. from a national cross-sectional study . The Lancet Respira Med 2020 ; 8 ( 11 ): 1081 - 93 . doi: 10.1016/S2213-2600(20)30155-7 https://dx.doi.org/10.1016/S2213-2600(20)30155-7 . DOI: 10.1016/S2213-2600(20)30155-7 http://doi.org/10.1016/S2213-2600(20)30155-7 https://linkinghub.elsevier.com/retrieve/pii/S2213260020301557 https://linkinghub.elsevier.com/retrieve/pii/S2213260020301557
Chen WQ , Zheng RS , Baade P , et al. Cancer Statistics in China, 2015 . CA: Cancer J Clin 2016 ; 66 ( 2 ): 115 - 32 . doi: 10.3322/caac.21338 https://dx.doi.org/10.3322/caac.21338 . DOI: 10.3322/caac.21338 http://doi.org/10.3322/caac.21338 http://doi.wiley.com/10.3322/caac.21338 http://doi.wiley.com/10.3322/caac.21338
Zeng HM , Chen WQ , Zheng RS , et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries . The Lancet Global Health 2018 ; 6 ( 5 ): e555 - e567 . doi: 10.1016/S2214-109X(18)30127-X https://dx.doi.org/10.1016/S2214-109X(18)30127-X . DOI: 10.1016/S2214-109X(18)30127-X http://doi.org/10.1016/S2214-109X(18)30127-X https://linkinghub.elsevier.com/retrieve/pii/S2214109X1830127X https://linkinghub.elsevier.com/retrieve/pii/S2214109X1830127X
Chen WQ , Xia CF , Zheng RS , et al. Disparities by province, age, and sex in site-specific cancer burden attributable to 23 potentially modifiable risk factors in China: a comparative risk assessment . The Lancet Global Health 2019 ; 7 ( 2 ): e257 - e269 . doi: 10.1016/S2214-109X(18)30488-1 https://dx.doi.org/10.1016/S2214-109X(18)30488-1 . DOI: 10.1016/S2214-109X(18)30488-1 http://doi.org/10.1016/S2214-109X(18)30488-1 https://linkinghub.elsevier.com/retrieve/pii/S2214109X18304881 https://linkinghub.elsevier.com/retrieve/pii/S2214109X18304881
Zhang JJ , Zhao YQ , Dai Yi , et al. Effectiveness of high-risk human papillomavirus testing for cervical cancer screening in China: a multicenter, open-label, randomized clinical trial . JAMA oncology 2021 ; 7 ( 2 ): 263 - 70 . doi: 10.1001/jamaoncol.2020.6575 https://dx.doi.org/10.1001/jamaoncol.2020.6575 . DOI: 10.1001/jamaoncol.2020.6575 http://doi.org/10.1001/jamaoncol.2020.6575
Ministry of Science and Technology of the People’s Republic of China . 2019 National Science and Technology Progress Award Winning Projects Catalogue . Available from: https://www.most.gov.cn/ztzl/gjkxjsjldh/jldh2019/jldh19jlgg/202001/t20200103_150916.html https://www.most.gov.cn/ztzl/gjkxjsjldh/jldh2019/jldh19jlgg/202001/t20200103_150916.html https://www.most.gov.cn/ztzl/gjkxjsjldh/jldh2019/jldh19jlgg/202001/t20200103_150916.html. Accessed:January 10, 2020 .
Zhu FC , Meng FY , Li JX , et al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial . The Lancet 2013 ; 381 ( 9882 ): 2024 - 32 . doi: 10.1016/S0140-6736(13)61049-1 https://dx.doi.org/10.1016/S0140-6736(13)61049-1 . DOI: 10.1016/S0140-6736(13)61049-1 http://doi.org/10.1016/S0140-6736(13)61049-1 https://linkinghub.elsevier.com/retrieve/pii/S0140673613610491 https://linkinghub.elsevier.com/retrieve/pii/S0140673613610491
Li RC , Liu LD , Mo ZJ , et al. An inactivated enterovirus 71 vaccine in healthy children . New Engl J Med 2014 ; 370 ( 9 ): 829 - 37 . doi: 10.1056/NEJMoa1303224 https://dx.doi.org/10.1056/NEJMoa1303224 . DOI: 10.1056/NEJMoa1303224 http://doi.org/10.1056/NEJMoa1303224 http://www.nejm.org/doi/10.1056/NEJMoa1303224 http://www.nejm.org/doi/10.1056/NEJMoa1303224
Xue J , Chong HH , Zhu YM , et al. Efficient treatment and pre-exposure prophylaxis in rhesus macaques by an HIV fusion-inhibitory lipopeptide . Cell 2021 ; 185 ( 1 ): 131 - 44 . doi: 10.1016/j.cell.2021.11.032 https://dx.doi.org/10.1016/j.cell.2021.11.032 . DOI: 10.1016/j.cell.2021.11.032 http://doi.org/10.1016/j.cell.2021.11.032
Ministry of Science and Technology of the People’s Republic of China . 2020 National Science and Technology Progress Award Winning Projects Catalogue . Available from: https://www.most.gov.cn/cxfw/kjjlcx/kjjl2020/202111/t20211103_177782.html https://www.most.gov.cn/cxfw/kjjlcx/kjjl2020/202111/t20211103_177782.html https://www.most.gov.cn/cxfw/kjjlcx/kjjl2020/202111/t20211103_177782.html. Released:November 2, 2021 ; accessed: September 10, 2022.
Ministry of Science and Technology of the People’s Republic of China . Catalog of the 2017 National Science and Technology Progress Award Winning Projects . Available from: https://www.most.gov.cn/ztzl/gjkxjsjldh/jldh2017/jldh17jlgg/201801/t20180103_137374.html https://www.most.gov.cn/ztzl/gjkxjsjldh/jldh2017/jldh17jlgg/201801/t20180103_137374.html https://www.most.gov.cn/ztzl/gjkxjsjldh/jldh2017/jldh17jlgg/201801/t20180103_137374.html. Released: January 8, 2018; accessed: September 10, 2022.
Ren LL , Wang YM , Wu ZQ , et al. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study . Chin Med J 2020 ; 133 ( 9 ): 1015 - 24 . doi: 10.1097/CM9.0000000000000722 https://dx.doi.org/10.1097/CM9.0000000000000722 . DOI: 10.1097/CM9.0000000000000722 http://doi.org/10.1097/CM9.0000000000000722 https://journals.lww.com/10.1097/CM9.0000000000000722 https://journals.lww.com/10.1097/CM9.0000000000000722
Wang C , Horby PW , Hayden FG , et al. A novel coronavirus outbreak of global health concern . The Lancet 2020 ; 395 ( 10223 ): 470 - 3 . doi: 10.1016/S0140-6736(20)30185-9 https://dx.doi.org/10.1016/S0140-6736(20)30185-9 . DOI: 10.1016/S0140-6736(20)30185-9 http://doi.org/10.1016/S0140-6736(20)30185-9 https://linkinghub.elsevier.com/retrieve/pii/S0140673620301859 https://linkinghub.elsevier.com/retrieve/pii/S0140673620301859
Pang XH , Ren LL , Wu SS , et al. COVID-19 Field Response Group, COVID-19 Laboratory Testing Group. Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing . Natl Sci Rev 2020 ; 7 ( 12 ): 1861 - 64 . doi: 10.1093/nsr/nwaa264 https://dx.doi.org/10.1093/nsr/nwaa264 . DOI: 10.1093/nsr/nwaa264 http://doi.org/10.1093/nsr/nwaa264
Wang YM , Zhang DY , Du GH , et al. Remdesivir in adults with severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial . The Lancet 2020 ; 395 ( 10236 ): 1569 - 78 . doi: 10.1016/S0140-6736(20)31022-9 https://dx.doi.org/10.1016/S0140-6736(20)31022-9 . DOI: 10.1016/S0140-6736(20)31022-9 http://doi.org/10.1016/S0140-6736(20)31022-9 https://linkinghub.elsevier.com/retrieve/pii/S0140673620310229 https://linkinghub.elsevier.com/retrieve/pii/S0140673620310229
Guo L , Wang G , Wang YM , et al. SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort study . The Lancet Microbe 2022 ; 3 ( 5 ): E348 - 56 . doi: 10.1016/S2666-5247(22)00036-2 https://dx.doi.org/10.1016/S2666-5247(22)00036-2 . DOI: 10.1016/S2666-5247(22)00036-2 http://doi.org/10.1016/S2666-5247(22)00036-2 https://linkinghub.elsevier.com/retrieve/pii/S2666524722000362 https://linkinghub.elsevier.com/retrieve/pii/S2666524722000362
Li L , Zhang W , Hu Yu , et al. Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial . JAMA 2020 ; 324 ( 5 ): 460 - 70 . doi: 10.1001/jama.2020.10044 https://dx.doi.org/10.1001/jama.2020.10044 . DOI: 10.1001/jama.2020.10044 http://doi.org/10.1001/jama.2020.10044
He ZY , Ren LL , Yang JT , et al. Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study . The Lancet 2021 ; 397 ( 10279 ): 1075 - 84 . doi: 10.1016/S0140-6736(21)00238-5 https://dx.doi.org/10.1016/S0140-6736(21)00238-5 . DOI: 10.1016/S0140-6736(21)00238-5 http://doi.org/10.1016/S0140-6736(21)00238-5 https://linkinghub.elsevier.com/retrieve/pii/S0140673621002385 https://linkinghub.elsevier.com/retrieve/pii/S0140673621002385
Chen SM , Zhang ZJ , Yang JT , et al. Fangcang shelter hospitals: a novel concept for responding to public health emergencies . The Lancet 2020 ; 395 ( 10232 ): 1305 - 14 . doi: 10.1016/S0140-6736(20)30744-3 https://dx.doi.org/10.1016/S0140-6736(20)30744-3 . DOI: 10.1016/S0140-6736(20)30744-3 http://doi.org/10.1016/S0140-6736(20)30744-3 https://linkinghub.elsevier.com/retrieve/pii/S0140673620307443 https://linkinghub.elsevier.com/retrieve/pii/S0140673620307443
Publicity Resources
Related Articles
Related Author
Related Institution