Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures

Xu Chen; Hong-Ling Liu; Jin-Sui Wang; Feng-Hui Zhao

doi:10.24920/004183

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Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures

Chinese Medical Sciences Journal Vol. 38, Issue 2, Pages: 130-137(2023)

Original article | Updated：2024-06-12

- Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures
- Affiliations：
  
  1. 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
  2. 2Department of Occupational Medicine, Third Gansu Provincial Hospital, Lanzhou 730000, China
- Author bio：
  
  *zhaofh0931@163.com
- Funds：
- DOI：10.24920/004183
  CLC：
- Received：18 October 2022，
  
  Accepted：2023-04-28，
  
  Published Online：06 June 2023，
  
  Published：30 June 2023
- Accepted：
Scan QR Code
Xu Chen, Hong-Ling Liu, Jin-Sui Wang, et al. Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures[J]. Chinese medical sciences journal, 2023, 38(2): 130-137.
DOI：

Xu Chen, Hong-Ling Liu, Jin-Sui Wang, et al. Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures[J]. Chinese medical sciences journal, 2023, 38(2): 130-137. DOI： 10.24920/004183.

摘要

目的

肺型原发性卵巢小细胞癌（primary small cell ovarian cancer of pulmonary type，SCCOPT）是一种预后不良的罕见卵巢肿瘤。目前，以铂类为基础的方案是其化疗的标准方案。由于发病率低，有关SCCOPT的临床特点以及其他治疗方法的潜在益处的研究较少。本研究总结了SCCOPT的临床病理特征和治疗。

方法

我们对2008年至2022年在甘肃省人民医院诊断的6例SCCOPT患者以及17篇英文文献和3篇中文文献报道的31例患者的临床、影像学、实验室和病理学特征进行了回顾性分析。

结果

患者的中位年龄为56.00岁。大约80%的患者处于Ⅲ或Ⅳ期。在手术和术后化疗后，患者的预后不良，中位总生存期为12个月。瘤体为囊实性，显微镜下可见小圆形肿瘤细胞和坏死。免疫组织化学检测显示：SCCOPT均表达上皮标志物—CD56和Y染色体相关性高迁移群盒2（sex-determining region of Y chromosom

e-related high-mobility-group box 2，SOX-2），不表达雌激素受体、孕激素受体、波形蛋白、Leu-7和生长抑素受体2。超过80%的肿瘤表达突触素。只有少数肿瘤表达神经元特异性烯醇酶、嗜铬粒蛋白A和甲状腺转录因子-1。

结论

SCCOPT预后不良。SOX-2有可能成为诊断SCCOPT的生物标记物。

Abstract

Objective

Primary ovarian small cell carcinoma of pulmonary type (SCCOPT) is a rare ovarian tumor with a poor prognosis. The platinum-based chemotherapy is the standard treatment. However

there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low incidence. The study aims to investigate clinicopathological characteristics and treatment of SCCOPT.

Methods

We summarized the clinical

imaging

laboratorical and pathological characteristics of 37 SCCOPT cases

in which 6 cases were admitted to the Gansu Provincial Hospital from the year of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese literatures.

Results

The median age of the studied SCCOPT cases (

=37) was 56.00 (range

22-80) years. Almost 80% of them had a stage Ⅲ or Ⅳ tumor. All patients underwent an operation and postoperative chemotherapy. Nevertheless

all cases had a poor prognosis

with a median overall survival time of 12 months. Immunohistochemically

the SCCOPT of all patients showed positive expressions of epithelial markers

such as CD56 and sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX-2)

and negative expressions of estrogen receptor

progesterone receptor

vimentin

Leu-7

and somatostatin receptor 2. The tumor of above 80% cases expressed synaptophysin. Only a few cases expressed neuron-specific enolase

chromogranin A

and thyroid transcription factor-1.

Conclusions

SCCOPT had a poor prognosis. SOX-2 could be a biomarker to be used to diagnose SCCOPT.

关键词

Keywords

references

Vora M , Lacour RA , Black DR , et al . Neuroendocrine tumors in the ovary: histogenesis, pathologic differentiation, and clinical presentation . Arch Gynecol Obstet 2016 ; 293 ( 3 ): 659 - 5 . doi: 10.1007/s00404-015-3865-0 https://dx.doi.org/10.1007/s00404-015-3865-0 . DOI: 10.1007/s00404-015-3865-0 http://doi.org/10.1007/s00404-015-3865-0

De Leo A , Santini D , Ceccarelli C , et al . What is new on ovarian carcinoma: integrated morphologic and molecular analysis following the New 2020 World Health Organization Classification of Female Genital Tumors . Diagnostics 2021 ; 11 ( 4 ): 697 . doi: 10.3390/diagnostics11040697 https://dx.doi.org/10.3390/diagnostics11040697 . DOI: 10.3390/diagnostics11040697 http://doi.org/10.3390/diagnostics11040697

Eichhorn JH , Young RH , Scully RE . Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic, and flow cytometric analysis of 11 cases . Am J Surg Pathol 1992 ; 16 ( 10 ): 926 - 38 . doi: 10.1097/00000478-199210000-00002 https://dx.doi.org/10.1097/00000478-199210000-00002 . DOI: 10.1097/00000478-199210000-00002 http://doi.org/10.1097/00000478-199210000-00002

Chang DHC , Hsueh S , Soong YK . Small cell carcinoma with neurosecretory granules arising in an ovarian dermoid cyst . Gynecol Oncol 1992 ; 46 ( 2 ): 246 - 50 . doi: 10.1097/00000478-199210000-00002 https://dx.doi.org/10.1097/00000478-199210000-00002 DOI: 10.1097/00000478-199210000-00002 http://doi.org/10.1097/00000478-199210000-00002

Fukunaga M , Endo Y , Miyazawa Y , et al . Small cell neuroendocrine carcinoma of the ovary . Virchows Archiv 1997 ; 430 ( 4 ): 343 - 8 . doi: 10.1007/BF01092759 https://dx.doi.org/10.1007/BF01092759 . DOI: 10.1007/BF01092759 http://doi.org/10.1007/BF01092759

Lim SC , Choi SJ , Suh CH . A case of small cell carcinoma arising in a mature cystic teratoma of the ovary . Pathol Int 1998 ; 48 ( 10 ): 834 - 9 . doi: 10.1111/j.1440-1827.1998.tb03846.x https://dx.doi.org/10.1111/j.1440-1827.1998.tb03846.x . DOI: 10.1111/j.1440-1827.1998.tb03846.x http://doi.org/10.1111/j.1440-1827.1998.tb03846.x

Mebis J , De Raeve H , Baekelandt M , et al . Primary ovarian small cell carcinoma of the pulmonary type: a case report and review of the literature . Eur J Gynecol Oncol 2004 ; 25 ( 2 ): 239 - 41 .

Grandjean M , Legrand L , Waterkeyn M , et al . Small cell carcinoma of pulmonary type inside a microinvasive mucinous cystadenocarcinoma of the ovary: a case report . Int J Gynecol Pathol 2007 ; 26 ( 4 ): 426 - 31 . doi: 10.1097/pgp.0b013e318039373a https://dx.doi.org/10.1097/pgp.0b013e318039373a . DOI: 10.1097/pgp.0b013e318039373a http://doi.org/10.1097/pgp.0b013e318039373a

Ishikawa A , Fujisawa H , Yasumura N , et al . Ovarian pulmonary-type small cell carcinoma diagnosed by means of ascitic fluid cytology: a case report with immunocytochemical analysis . Cytopathology 2021 ; 32 ( 2 ): 250 - 2 . doi: 10.1111/cyt.12918 https://dx.doi.org/10.1111/cyt.12918 . DOI: 10.1111/cyt.12918 http://doi.org/10.1111/cyt.12918

Rund CR , Fischer EG . Perinuclear dot-like cytokeratin 20 staining in small cell neuroendocrine carcinoma of the ovary (pulmonary-type) . Appl Immunohistochem Mol Morphol 2006 ; 14 ( 2 ): 244 - 8 . doi: 10.1097/01.pai.0000155796.49278.62 https://dx.doi.org/10.1097/01.pai.0000155796.49278.62 . DOI: 10.1097/01.pai.0000155796.49278.62 http://doi.org/10.1097/01.pai.0000155796.49278.62

Rubio A , Schuldt M , Chamorro C , et al . Ovarian small cell carcinoma of pulmonary type arising in mature cystic teratomas with metastases to the contralateral ovary . Int J Surg Pathol 2015 ; 23 ( 5 ): 388 - 92 . doi: 10.1177/1066896915586254 https://dx.doi.org/10.1177/1066896915586254 . DOI: 10.1177/1066896915586254 http://doi.org/10.1177/1066896915586254

Suzuki N , Kameyama K , Hirao T , et al . A case of pulmonary type of ovarian small cell carcinoma . J Obstet Gynecol Res 2007 ; 33 ( 2 ): 203 - 6 .doi: 10.1111/j.1447-0756.2007.00494.x https://dx.doi.org/10.1111/j.1447-0756.2007.00494.x . DOI: 10.1111/j.1447-0756.2007.00494.x http://doi.org/10.1111/j.1447-0756.2007.00494.x

Tsolakidis D , Papanikolaou A , Ktenidis K , et al . Primary ovarian small cell carcinoma of pulmonary type with enlarged paraaortic lymph node masses: a case report and review of the literature . Eur J Gynecol Oncol 2012 ; 33 ( 3 ): 312 - 5 .

Kurasaki A , Sakurai N , Yamamoto Y , et al . Ovarian pulmonary-type small cell carcinoma: case report and review of the literature . Int J Gynecol Pathol 2013 ; 32 ( 5 ): 464 - 70 . doi: 10.1097/PGP.0b013e31826d7ea8 https://dx.doi.org/10.1097/PGP.0b013e31826d7ea8 . DOI: 10.1097/PGP.0b013e31826d7ea8 http://doi.org/10.1097/PGP.0b013e31826d7ea8

Ikota H , Kaneko K , Takahashi S , et al . Malignant transformation of ovarian mature cystic teratoma with a predominant pulmonary type small cell carcinoma component . Pathol Int 2012 ; 62 ( 4 ): 276 - 80 . doi: 10.1111/j.1440-1827.2012.02804.x https://dx.doi.org/10.1111/j.1440-1827.2012.02804.x . DOI: 10.1111/j.1440-1827.2012.02804.x http://doi.org/10.1111/j.1440-1827.2012.02804.x

Hashimoto H , Kurata A , Fujita K , et al . Ovarian small cell carcinoma of pulmonary type appearing in ante-mortem ascites: an autopsy case and review of the literature . Human Pathol: Case Rep 2015 ; 2 ( 3 ): 67 - 72 . doi: 10.1016/j.ehpc.2015.02.003 https://dx.doi.org/10.1016/j.ehpc.2015.02.003 . DOI: 10.1016/j.ehpc.2015.02.003 http://doi.org/10.1016/j.ehpc.2015.02.003

Kalampokas E , Sharma V , Gagliardi T , et al . Primary small cell ovarian cancer of pulmonary type: a case report . Gynecol Oncol Rep 2018 ; 24 : 10 - 3 . doi: 10.1016/j.gore.2018.02.003 https://dx.doi.org/10.1016/j.gore.2018.02.003 . DOI: 10.1016/j.gore.2018.02.003 http://doi.org/10.1016/j.gore.2018.02.003

Oneda E , Zorzi F , Gorio A , et al . Differential diagnosis of small cell carcinoma of the ovary or ovarian metastases of small cell carcinoma of the lung: a case report and review of the literature . Case Rep Oncol 2020 ; 13 ( 2 ): 822 - 8 . doi: 10.1159/000507978 https://dx.doi.org/10.1159/000507978 . DOI: 10.1159/000507978 http://doi.org/10.1159/000507978

Asom AS , Lastra RR , Hasan Y , et al . Small cell carcinoma of the ovary, pulmonary type: a role for adjuvant radiotherapy after carboplatin and etoposide? Gynecol Oncol Rep 2022 ; 39 : 100925 . doi: 10.1016/j.gore.2022.100925 https://dx.doi.org/10.1016/j.gore.2022.100925 . DOI: 10.1016/j.gore.2022.100925 http://doi.org/10.1016/j.gore.2022.100925

Wang YL , Zou SY , Yue XH , et al . Small cell carcinoma of the ovary, pulmonary type: a case report and literature review . J Clin Ex Pathol 2005 ( 3 ): 367 - 8 . doi: 10.13315/j.cnki.cjcep.2005.03.041 https://dx.doi.org/10.13315/j.cnki.cjcep.2005.03.041 . DOI: 10.13315/j.cnki.cjcep.2005.03.041 http://doi.org/10.13315/j.cnki.cjcep.2005.03.041

Ouyang ZB , Su HH , Zhong BL , et al . Primary ovarian small cell carcinoma of pulmonary type: a case report and literature review . Chin J Cancer Prev Treat 2014 ; 21 ( 1 ): 69 - 71 . doi: 10.16073/j.cnki.cjcpt.2014.01.001 https://dx.doi.org/10.16073/j.cnki.cjcpt.2014.01.001 . DOI: 10.16073/j.cnki.cjcpt.2014.01.001 http://doi.org/10.16073/j.cnki.cjcpt.2014.01.001

Li Y , Yang GQ , Shuang YJ , et al . Primary ovarian small cell carcinoma of pulmonary type: a case report and literature review . Diagnos Imaging Intervent Radiol 2021 ; 30 ( 1 ): 64 - 7 . doi: 10.3969/j.issn.1005-8001.2021.01.013 https://dx.doi.org/10.3969/j.issn.1005-8001.2021.01.013 . DOI: 10.3969/j.issn.1005-8001.2021.01.013 http://doi.org/10.3969/j.issn.1005-8001.2021.01.013

Shahrokhi P , Emami-Ardekani A , Karamzade-Ziarati N . SSTR-based theranostics in neuroendocrine prostate cancer (NEPC) . Clin Transl Imaging 2022 ; 22 ( 11 ): 1 - 8 . doi: 10.1007/s40336-022-00535-3 https://dx.doi.org/10.1007/s40336-022-00535-3 . DOI: 10.1007/s40336-022-00535-3 http://doi.org/10.1007/s40336-022-00535-3

Burki TK . Small-cell carcinoma of the ovary, hypercalcaemic type . Lancet Oncol 2014 ; 15(6): e201 . doi: 10.1016/S1470-2045(14)70144-5 https://dx.doi.org/10.1016/S1470-2045(14)70144-5 . DOI: 10.1016/S1470-2045(14)70144-5 http://doi.org/10.1016/S1470-2045(14)70144-5

Errichiello E , Mustafa N , Vetro A , et al . SMARCA4 inactivating mutations cause concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type . J Pathol 2017 ; 243 ( 1 ): 9 - 15 . doi: 10.1002/path.4926 https://dx.doi.org/10.1002/path.4926 . DOI: 10.1002/path.4926 http://doi.org/10.1002/path.4926

Gandhi JS , Alnoor F , Sadiq Q , et al . SMARCA4 (BRG1) and SMARCB1 (INI1) expression in TTF-1 negative neuroendocrine carcinomas including merkel cell carcinoma . Pathol Res Pract 2021 ; 219 : 153341 . doi: 10.1016/j.prp.2021.153341 https://dx.doi.org/10.1016/j.prp.2021.153341 . DOI: 10.1016/j.prp.2021.153341 http://doi.org/10.1016/j.prp.2021.153341 https://linkinghub.elsevier.com/retrieve/pii/S0344033821000029 https://linkinghub.elsevier.com/retrieve/pii/S0344033821000029

William WN , Glisson BS . Novel strategies for the treatment of small-cell lung carcinoma . Nat Rev Clin Oncolo 2011 ; 8 ( 10 ): 611 - 9 . doi: 10.1038/nrclinonc.2011.90 https://dx.doi.org/10.1038/nrclinonc.2011.90 . DOI: 10.1038/nrclinonc.2011.90 http://doi.org/10.1038/nrclinonc.2011.90

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