Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case

Li-Ping Zhu; Rui Tang; Qing Wang; Hong Li

doi:10.24920/004208

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Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case

Chinese Medical Sciences Journal Vol. 38, Issue 2, Pages: 159-162(2023)

Case Report | Updated：2024-06-12

- Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case
- Affiliations：
  
  Allergy Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  *Hong Li, E-mail: lihong@pumch.cn.
- Funds：
- DOI：10.24920/004208
  CLC：
- Received：28 January 2023，
  
  Accepted：2023-04-24，
  
  Published Online：18 May 2023，
  
  Published：30 June 2023
- Accepted：
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Li-Ping Zhu, Rui Tang, Qing Wang, et al. Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case[J]. Chinese medical sciences journal, 2023, 38(2): 159-162.
DOI：

Li-Ping Zhu, Rui Tang, Qing Wang, et al. Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case[J]. Chinese medical sciences journal, 2023, 38(2): 159-162. DOI： 10.24920/004208.

摘要

食物依赖运动诱发严重过敏反应（food-dependent

exercise-induced anaphylaxis，FDEIA）是一种潜在可威胁患者生命的过敏性疾病，常在进食可疑致敏食物数小时内运动时发作。该病极罕见，患病率约为0.02%，目前尚无预防方法。现报告一例度普利尤单抗治疗11岁FDEIA患儿。该患儿在就诊前2年内发生了10余次不明原因的严重过敏反应，常规治疗后症状未获控制。后在我科行7次度普利尤单抗皮下注射治疗，为期33周。在第7次治疗时被诊断为菌菇引发的FDEIA。度普利尤单抗治疗期间，患儿每月至少有2次在进食蘑菇数小时内进行运动，但未再发严重过敏反应。目前尚未见报告阐明度普利尤单抗治疗食物诱导的IgE型严重过敏反应的临床意义，尤其是对于FDEIA这种罕见疾病。因此，本病例或可为儿童严重过敏反应症状的控制和改善提供新的治疗思路。

Abstract

Food-dependent

exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening disorder that often occurs with exercise

and patients typically have eaten a specific food within hours before disease onset. This disease is exceedingly rare

with a prevalence of 0.02%. No well-recognized prevention or treatment strategy has been available for FDEIA except avoiding triggers strictly. Here we report an 11-year-old boy with a history of recurrent anaphylaxis of unknown etiology more than 10 times within two years. As the anaphylactic symptoms had not been controlled after traditional treatments

the patient was given subcutaneous injection of dupilumab seven times within 33 weeks. During dupilumab treatments

the patient was exposed to culprit mushrooms plus exercises at least twice a month but without notable anaphylaxis. Thus

Dupilumab may improve the allergic reactions in FDEIA patients.

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references

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Li-Ping Zhu

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Allergy Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

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