Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats

Xue Yutao; Tan Ning; Yu Gangyan; Tan Li; Lu Yang

doi:10.24920/11806

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Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats

Chinese Medical Sciences Journal Vol. 33, Issue 2, Pages: 107-113(2018)

Original Article | Updated：2024-04-10

- Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats
- Affiliations：
  
  北京中医药大学中药学院中药制药系,北京 100029 中国
- Author bio：
- Funds：
- DOI：10.24920/11806
  CLC：
- Received：23 July 2017，
  
  Published Online：20 June 2018，
  
  Published：20 June 2018
- Accepted：
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Xue Yutao, Tan Ning, Yu Gangyan, et al. Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats[J]. Chinese medical sciences journal, 2018, 33(2): 107-113.
DOI：

Xue Yutao, Tan Ning, Yu Gangyan, et al. Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats[J]. Chinese medical sciences journal, 2018, 33(2): 107-113. DOI： 10.24920/11806.

摘要

目的

探讨红参与阿司匹林联用对大鼠体内阿司匹林代谢物的药代动力学影响。

方法

12只雄性SD大鼠随机均分为阿司匹林单用组（阿司匹林10.42 mg/kg）和红参、阿司匹林联用组（红参提取物0.5 mg/g + 阿司匹林10.42 mg/kg）。经灌胃给药。分别于灌胃前及灌胃后0.083

0.25

0.5

10及12 h经眼眶取血0.5 ml

采用HPLC-UV分析大鼠血浆中阿司匹林代谢物——水杨酸的血药浓度

采用DAS3.0软件的非房室模型计算水杨酸的药代动力学参数

并对两组的参数进行比较。

结果

与阿司匹林单用组相比

联用组的水杨酸最大血药浓度和药时曲线下面积显著增加（P

0.01）

清除率显著降低（P

0.05）。

结论

红参可能具有促进阿司匹林在大鼠体内吸收

延缓其代谢产物——水杨酸代谢的作用。

Abstract

Objective

To investigate whether red ginseng extract can affect the pharmacokinetics of aspirin in Sprague Dawley (SD) rats.

Methods

Totally

12 male SD rats were randomly and uniformly divided into the aspirin group (aspirin 10.42 mg·kg

-1

) and the combined group (red ginseng extraction 0.5 mg·g

-1

+ aspirin 10.42 mg·kg

-1

). After intragastric administration of drugs

blood samples (0.5 ml once) were drawn from orbit at 0.083

0.25

0.5

10 and 12 hours after dosing. Plasma concentration of salicylic acid (metabolite of aspirin) was detected with ultraviolet-visible high performance liquid chromatography (HPLC). The reliability of the procedure was verified with respect to specificity

linearity

accuracy

precision

extraction recovery and matrix effect

and stability. Pharmacokinetics of salicylic acid was evaluated by using non-compartmental model.

Results

The method was proved to be validated. Compared with the aspirin group

area under the curve (AUC

0-t

) and maximum concentration of salicylic acid in rats of the combined group increased obviously (

0.01)

while clearance rate (CL

/F) decreased clearly (

0.05).

Conclusion

The

in vivo

study showed that red ginseng extract can help the internal absorption of aspirin

and delay the

in vivo

metabolism of aspirin.

关键词

Keywords

references

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