Resuscitation of Septic Patients with Target-and-endpoint Protocol: A Retrospective Study from a Chinese Tertiary Hospital ICU

Zhang Hongmin; Wang Xiaoting; Zhang Qing; Liu Dawei

doi:10.24920/11816

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Resuscitation of Septic Patients with Target-and-endpoint Protocol: A Retrospective Study from a Chinese Tertiary Hospital ICU

Chinese Medical Sciences Journal Vol. 33, Issue 3, Pages: 135-142(2018)

ORIGINAL ARTICLE | Updated：2024-04-10

- Resuscitation of Septic Patients with Target-and-endpoint Protocol: A Retrospective Study from a Chinese Tertiary Hospital ICU
- Affiliations：
  
  中国医学科学院北京协和医学院北京协和医院重症医学科,北京 100730
- Author bio：
- Funds：
- DOI：10.24920/11816
  CLC：
- Published Online：20 September 2018，
  
  Published：20 September 2018
- Accepted：
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Zhang Hongmin, Wang Xiaoting, Zhang Qing, et al. Resuscitation of Septic Patients with Target-and-endpoint Protocol: A Retrospective Study from a Chinese Tertiary Hospital ICU[J]. Chinese medical sciences journal, 2018, 33(3): 135-142.
DOI：

Zhang Hongmin, Wang Xiaoting, Zhang Qing, et al. Resuscitation of Septic Patients with Target-and-endpoint Protocol: A Retrospective Study from a Chinese Tertiary Hospital ICU[J]. Chinese medical sciences journal, 2018, 33(3): 135-142. DOI： 10.24920/11816.

摘要

目的

探讨“目标与目的”方案进行脓毒症复苏的效果。

方法

回顾性研究北京协和医院以脓毒症收入且应用去甲肾上腺素维持血压的患者545例。记录患者的一般资料

入室时、入室6及24 h动脉血乳酸水平

平均动脉压（MAP）、中心静脉压（CVP）、中心静脉血氧饱和度（ScvO2）以及乳酸清除率、住院死亡率等。

结果

患者的6h乳酸清除率为21.6%（四分位距

8.6%-39.0%）

住院死亡率为9.4%。入室时低CVP（

8 mm Hg

1 mm Hg=0.133 kPa）患者

6h后CVP显著上升（5.4 ± 1.6 mm Hg 比7.7 ± 2.6 mm Hg

0.001）。入室时低MAP（

75 mm Hg）患者

6h后MAP显著升高（64.2 ± 7.1 mm Hg比82.2 ± 13.1 mm Hg

0.001）。入室时低ScvO2 （

70%）患者

6h后ScvO2显著升高（61.9% ± 7.0%比71.9% ± 7.8%

0.001）。各参数于6h和24h无明显变化。入室时高CVP （≥8 mm Hg）患者

6h后CVP 显著下降（11.3 ± 4.0 mm Hg比10.3 ± 2.9 mm Hg

0.001）。入室时高MAP（≥ 75 mm Hg）患者

6h后MAP显著下降（94.2 ± 13.9 mm Hg比89.4 ± 11.4 mm Hg

0.001）。入室时高ScvO2（≥ 70%）患者

6h后ScvO2显著下降（76.8% ± 4.2%比72.9% ± 7.3%

0.001）。各参数于6h和24h无明显变化。

结论

在对脓毒症患者进行复苏时

早期目标指导治疗提出的“目标正常值”并非适合于所有患者。“目标与目的”复苏方案能使治疗目标个体化

值得进一步研究。

Abstract

Objective

To investigate the effect of target-and-endpoint protocol on the resuscitation of septic patients.

Methods

This is a retrospective study performed at the Peking Union Medical College Hospital Intensive Care Unit. We enrolled 545 septic patients who needed vasopressors on at least the first day of ICU admission. The general characteristics

blood lactate level

mean arterial pressure (MAP)

central venous pressure (CVP) and saturation of central venous oxygen (ScvO

) at admission and 6

24 hours after admission were collected. The parameters at different time points were compared. Lactate clearance rate and in-hospital mortality were analyzed.

Results

The 6-hour lactate clearance rate was 21.6% (IQR

8.6%-39.0%)

and in-hospital mortality was 9.4%. For patients with low CVP values (

8 mm Hg

1 mm Hg=0.133 kPa) at admission

CVP increased significantly at 6 hours after admission (5.4±1.6 mm Hg

. 7.7±2.6 mm Hg

0.001). For patients with low MAP (

75 mm Hg) at admission

the MAP values increased significantly at 6 hours (64.2±7.1 mm Hg

. 82.2±13.1 mm Hg

0.001). For patients with low ScvO

value (

70%) at admission

the ScvO

value increased significantly at 6 hours (61.9%±7.0%

. 71.9%±7.8%

0.001). No difference was found between the values at 6 hours and the corresponding values at 24 hours after admission. For patients with high CVP values (≥8 mm Hg) at admission

CVP decreased significantly at 6 hours (11.3±4.0 mm Hg

. 10.3±2.9 mm Hg

0.001). For patients with high MAP (≥75 mm Hg) at admission

the MAP values decreased significantly at 6 hours (94.2±13.9 mm Hg

. 89.4±11.4 mm Hg

0.001). For patients with high ScvO

value (≥70%) at admission

the ScvO

values decreased significantly at 6 hours (76.8%±4.2%

. 72.9%±7.3%

0.001). No difference was found between the values at 6 hours and the corresponding values at 24 hours.

Conclusions

This study suggested that in the resuscitation of sepsis and septic shock patients in the ICU

the target values did not need to be within the “normal range” recommended by early-goal directed therapy. The “target-and-endpoint” protocol

which aimed for personalized goals

deserves more consideration.

关键词

Keywords

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