Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy

Ni Jieming; Ni Anping

doi:10.24920/21804

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Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy

Chinese Medical Sciences Journal Vol. 33, Issue 3, Pages: 174-182(2018)

REVIEW | Updated：2024-04-10

- Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy
- Affiliations：
  
  1 Seven Year Program of China Medical University, Shenyang 110122, China
  2 Department of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
- Author bio：
- Funds：
- DOI：10.24920/21804
  CLC：
- Published Online：20 September 2018，
  
  Published：20 September 2018
- Accepted：
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Ni Jieming, Ni Anping. Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy[J]. Chinese medical sciences journal, 2018, 33(3): 174-182.
DOI：

Ni Jieming, Ni Anping. Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy[J]. Chinese medical sciences journal, 2018, 33(3): 174-182. DOI： 10.24920/21804.

摘要

PD-1/PD-L1 是重要的免疫检查点

PD-1/PD-L1功能障碍导致肿瘤转移和免疫逃逸。PI3K/Akt/mTOR、MAPK 信号网络诱导PD-1/PD-L1表达并促进肿瘤发展;转录因子 HIF、PTEN、p53、CDK5、BRD4、STAT 调节PD-1/PD-L1表达;PD-1/PD-L1水平也受表观修饰和翻译后修饰调节

以上调控机制均作为潜在的肿瘤治疗靶点。目前

PD-1/PD-L1单克隆抗体及小分子抑制剂联合治疗肿瘤在临床上取得了良好的效果。

Abstract

Programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) is a significant immune checkpoint

and the dysfunction of this axis contributes to tumor metastasis and immune escape. PI3K/Akt/mTOR and MAPK signal network induces PD-1/PD-L1 expression and facilitates tumor progression. Transcriptional factors such as hypoxia induced factors

PTEN

p53

CDK5

BRD4

STAT modulate PD-1/PD-L1 expression. PD-1/PD-L1 level is also regulated

via

epigenetic and post-translational manner. The underlying mechanisms mentioned above may provide potential targets for tumor treatment. At present

the combination therapy of PD-1/PD-L1 monoclonal antibodies plus small molecular inhibitors has achieved good outcomes in tumor treatment.

关键词

Keywords

references

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