Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus: A Pilot MRI Study<sup>△</sup>

Chen Zhiye; Zang Xiujuan; Liu Mengqi; Liu Mengyu; Li Jinfeng; Gu Zhaoyan; Ma Lin

doi:10.24920/J1001-9294.2017.010

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Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus: A Pilot MRI Study^△

Chinese Medical Sciences Journal Vol. 32, Issue 2, Pages: 75-82(2017)

Orginal Article | Updated：2024-04-10

- Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus: A Pilot MRI Study^△
- Affiliations：
  
  1. 1Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China
  2. 2Department of Radiology, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan 572013, China
  3. 3Department of Radiology, The Fifth People's Hospital, Shizuishan, Ningxia 753000, China
  4. 4Department of Endocrinology, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan 572013, China
- Author bio：
  
  *Corresponding author Tel: 86-10-66939592, E-mail: cjr.malin@vip.163.com.
- Funds：
- DOI：10.24920/J1001-9294.2017.010
  CLC：
- Received：09 September 2016，
  
  Published Online：20 June 2017，
  
  Published：2017-06
- Accepted：
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Chen Zhiye, Zang Xiujuan, Liu Mengqi, et al. Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus: A Pilot MRI Study^△[J]. Chinese medical sciences journal, 2017, 32(2): 75-82.
DOI：

Chen Zhiye, Zang Xiujuan, Liu Mengqi, et al. Abnormal Alterations of Cortical Thickness in 16 Patients with Type 2 Diabetes Mellitus: A Pilot MRI Study^△[J]. Chinese medical sciences journal, 2017, 32(2): 75-82. DOI： 10.24920/J1001-9294.2017.010.

摘要

目的

采用基于磁共振成像的全脑皮层厚度分析方法研究2型糖尿病患者脑部皮层厚度的异常变化。

方法

对16名新发2型糖尿病患者及16名健康志愿者行高分辨三维T1快速毁损梯度回波成像。基于Freesurfer软件（4.3.0版）计算全脑皮层厚度图

并采用基于脑回的感兴趣区法计算各个脑区的皮层厚度。以年龄和性别作为协变量进行协方差分析比较各个脑区的平均皮层厚度。采用基于表面的皮层厚度分析法在全脑水平比较皮层厚度的局部差异。

结果

2型糖尿病患者双侧大脑皮层厚度（左侧：2.52±0.07 mm;右侧：2.51±0.08 mm）较对照组（左侧：2.56±0.09 mm;右侧：2.56±0.09 mm）变薄（P

0.05）。2型糖尿病患者较正常对照组局部脑回变薄的脑区主要位于旁中央叶、中央后回、枕外侧回、舌回、楔前回、颞上回、颞中回、颞下回及后扣带回。左侧中扣带回及右侧颞下回皮层厚度与2型糖尿病病程呈负相关。

结论

新发2型糖尿病患者可发生脑部广泛皮层变薄。本研究结果证实了2型糖尿病可导致脑部微小结构发生改变。

Abstract

Objective

The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus (T2DM) using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging (MRI).

Methods

High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM

as well as from 16 normal controls. The whole brain cortical thickness maps were generated

and the cortical thickness of each brain region was calculated according to gyral based regions of interest (ROI) using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness.

Results

Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM (left: 2.52±0.07 mm; right: 2.51±0.08 mm) were significant thinner than those in the normal controls (left: 2.56±0.09 mm; right: 2.56±0.09 mm) (both

0.05). Regional cortical thinning in T2DM was demonstrated in the paracentral lobule

postcentral gyrus

lateral occipital gyrus

lingual gyrus

precuneus

superior temporal gyrus

middle temporal gyrus

inferior temporal gyrus and posterior cingulate gyrus

compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course.

Conclusion

A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.

关键词

Keywords

references

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