The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars

Li Zifei; Liu Qingliang; Wang Xiaojun; Luan Jie

doi:10.24920/J1001-9294.2017.014

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The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars

Chinese Medical Sciences Journal Vol. 32, Issue 2, Pages: 113-118(2017)

Orginal Article | Updated：2024-04-10

- The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars
- Affiliations：
  
  1. 1Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
  2. 2Division of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
- Author bio：
  
  *Corresponding author Tel: 86-17801014078, Fax: 86-10-69152711, E-mail: wxjpumch@163.com(Xiaojun Wang); 86-13341419733, Fax: 86-10-69152710, E-mail: JieLuands@163.com(Jie Luan).
- Funds：
- DOI：10.24920/J1001-9294.2017.014
  CLC：
- Received：27 June 2016，
  
  Published Online：20 June 2017，
  
  Published：2017-06
- Accepted：
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Li Zifei, Liu Qingliang, Wang Xiaojun, et al. The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars[J]. Chinese medical sciences journal, 2017, 32(2): 113-118.
DOI：

Li Zifei, Liu Qingliang, Wang Xiaojun, et al. The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars[J]. Chinese medical sciences journal, 2017, 32(2): 113-118. DOI： 10.24920/J1001-9294.2017.014.

摘要

血供在病理性瘢痕的形成中起到重要作用

近年来备受关注。然而关于血管分布、血管结构、血流量的相关研究结论争议颇多。此外

缺氧微环境在病理性瘢痕组织的血管化过程中起到重要作用

影响相关代谢指标及细胞因子的表达。血供与组织缺氧之间有密切关系

但仍不甚明了。本文就病理性瘢痕血供及组织缺氧的研究进展进行综述

阐述病理性瘢痕的血供特点及与组织缺氧的联系

并对未来研究方向进行展望。

Abstract

Blood supply is believed to be an important aspect in the development of pathological scars. However

there are controversies about vascular distribution

vascular structure and blood flow in pathological scars. Additionally

hypoxic microenvironment plays an important role in the vascularization of pathological scar tissues

and hypoxic conditions can be reflected by metabolic indexes and some cytokines. Furthermore

the correlation between blood supply and tissue hypoxia is controversial. The aim of this article is to review the literature on the characteristics of blood supply and tissue hypoxia in pathological scars

from which we can see pathological scars have unique characteristics of blood supply that are closely associated with tissue hypoxia. Moreover

development in the treatment of pathological scars is herein reviewed.

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references

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