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Volume ， Issue 2 ， 1995
- Abstract：The polymorphisms of variable number of tandem repeats （VNTR） 3’to the apolipoprotein B （apo B） gene were investigated using polymerase chain reaction （PCR） in a sample of 103 patients with documented coronary heart disease （CHD） and 100 healthy individuals selected from Chinese Han nationality.Twelve segregating alleles （3’β29 -51） were observed in the pooled total of 203 subjects. The most common allele was 3’β 37. followed by 3’β39 with frequencies of 0. 362 and 0. 296, respectively. This model of allele distribution was coincident with the results form different ethnic groups, but the relative frequencies of alleles were different. In comparison with the allele frequencies between the patients and controls,alleles bigger than 3’β39 （3’VNTR-B） were significantly more common among the patients than among the controls （P<0. 001）. Moreover. in the CHD group patients with plasma levels of TC≥3.88 mmol/L,LDL-C≥2. 59 mmol/L and HDL-C<l. 16mmol/L had significantly higher frequencies of 3’ VNTR-B allele （P<0. 01）. Therefore,it is suggested that 3’ VNTR-B allele might be involved in the development of coronary atherosclerosis, presumably through their influences on lipid metabolism.This study supported by “8. 5” grant from Ministry of PublicHealth.4|13|1Updated：2024-04-10
- Abstract：ＥｐｉｄｅｍｉｏｌｇｉｃＳｔｕｄｙｏｆＡｃｕｔｅＨｉｇｈＡｌｔｉｔｕｄｅＰｕｌｍｏｎａｒｙＥｄｅｍａＺｈｏｕＱｉｑｕａｎ（周其全）ａｎｄＹａｎｇＪｉｎｇｙｉ（杨景义）（ＬａｎｚｈｏｕＭｅｄｉｃａｌＣｏｌｌｅｇｅｏｆＰＬＡ，Ｌａｎｚｈｏｕ７３００２０）...4|5|0Updated：2024-04-10
- Abstract：It is well established that genetic and environmental factors are involved in the etiology of essential hypertension（EH）. Previous studies have suggested that at least one of the HLA genes is responsible for the genetic susceptibility to EH. Our aim in the present study was to investigate this issue in China by the PCR-SSP HLA-DRB1 typing method. The results showed an increased frequency of HLA-DR2 and a decreased frequency of HLA-DR7 with EH patients compared with controls. We consider that HLA-DR2 may represent a marker for susceptibility to FH in the North Chinese population.3|7|1Updated：2024-04-10
- Abstract：ＡＣｌｉｎｉｃａｌＳｔｕｄｙｏｎｔｈｅＲｅｌａｔｉｏｎｓｈｉｐＢｅｔｗｅｅｎＤＮＡ－ＰａｎｄＡＬＴｏｆＡｃｕｔｅ ＨｅｐａｔｉｔｉｓＢＧｏｎｇＪｉａｎｌｉｎｇ（公建玲）；ＣａｏＧｕｏｍｉｎｇ（曹国鸣）ａｎｄＸｉｏｎｇＬｉｌａｎ（熊丽兰）(２０５Ｈｏｓ...4|6|0Updated：2024-04-10
- Abstract：The effect of lipopolysaccharide （LPS） on the exposure of platelet fibrinogen receptors was investigated. The results showed that:l)LPS increased the binding of fibrinogen-gold complexes to platelets and the labels were primarily limited to shape-changed platelets; 2) LPS caused a dose-dependent rise in intracellular Ca2+ concentration in platelets; 3)LPS induced the activation of platelet protein kinase C （PKC） and the phosphorylation of glycoprotein llla （GPllla） which was inhibited by H-7. All these results suggest that stimulation of platelets with LPS causes a conformational change in glycoprotein llb/llla （GPllb/llla）through platelet shape change and /or phosphorylation of GPllla via PKC, which serves to expose the fibrinogen binding sites of GPllb/llla on human platelets.4|5|1Updated：2024-04-10
- Abstract：ＭｉｃｒｏｅｎｃａｐｓｕｌａｔｅｄＨｕｍａｎＰｉｔｕｉｔａｒｙＡｄｅｎｏｍａＣｅｌｌｓＩｎＶｉｔｒｏａｎｄｉｎＶｉｖｏＣｈｅｎＺｈｏｎｇｐｉｎｇ（陈忠平）；ＢａｏＹａｏｄｏｎｇ（鲍耀东）ａｎｄＨｕｉＧｕｏｚｈｅｎ（惠国桢）(ＤｅｐａｒｔｍｅｎｔｏｆＮ...4|9|0Updated：2024-04-10
- Abstract：In the present study, four different proteases （pepsin, papain, bromelain and ficin） were screened with a murine monoclonal antibody OC859 , in order to verify whether different digestion procedures could improve yield and stability of the F（ab’）2 or Fab fragments. The yields of F（ab’）2 or Fab fragments from digestion with pepsin, papain , bromelain and ficin were respectively 20. 3+/-2. 0%, 50. 5+/-5. 0%,74. 4+/-2. 7% and 82. 8 +/-10. 2% of the theoretical maximum. Immunoreactivity in a noncompetitive solid-phase radioimmunoassay （SPRIA） of the fragments generated by the four proteases were respectively 10+/-5%, 36+/-5%, 60+/-6% and 75+/-6%of the intact OC859 IgG. These results suggested that the fragmentation of OC859 with ficin gave a higher yield of superior immunoreactive fragments.4|14|3Updated：2024-04-10
- Abstract：ＴｈｅＡｇｇｒｅｇａｔｉｖｅＲｅｓｐｏｎｓｅｏｆＰｓｏｒｉａｔｉｃＢｌｏｏｄＰＭＮｔｏＰＡＦａｎｄｔｈｅＥｆｆｅｃｔｏｆＰＡＦＡｎｔａｇｏｎｉｓｔｏｎｔｈｅＡｇｇｒｅｇａｔｉｏｎＬｉｕＢａｏｊｕｎ（刘宝军）；ＺｈａｎｇＨａｉｔａｏ（张海涛）；Ｚｈｅｎ...4|6|0Updated：2024-04-10
- Abstract：Biophysical studies were conducted on the action of laminin through membrane receptors of cancer cells. The results showed that variations occurred in the thermodynamic properties of membrane proteins,the mobility of hydrocarbon chains of membrane lipids, and the permeability and transportation pathways of the membrane.4|8|4Updated：2024-04-10
- Abstract：ＡｎａｌｙｓｉｓｏｆＴｈｅｒａｐｅｕｔｉｃＥｆｆｅｃｔｓｏｎ７２ＣａｓｅｓｏｆＡｃｕｔｅＨｉｇｈＡｌｔｉｔｕｄｅＣｅｒｅｂｒａｌＥｄｅｍａＴｒｅａｔｅｄｏｎｔｈｅＳｐｏｔＩｎＨｉｇｈＡｌｔｉｔｕｄｅＲｅｇｉｏｎｓＹａｎｇＪｉｎｇｙｉ（杨景义）ａｎｄＺ...4|7|0Updated：2024-04-10
- Abstract：The changes of several immune functions were observed in rats after they were inflicted with 6 Gy gamma rays irradiation, 15% TBSA full thickness brun and the combination of the 2 injuries. It was found that the functions of thymocytes and splenocytes suffered the most severe suppression in the 24th to 72nd hour after radiation injury and began to recover on the 7th day. In the rats with burn injury, the suppression on thymocytes and splenocytes were significantly less severe than that after radiation and recovered more rapidly. The effects of combined radiation-burn injury showed several characteristics. The suppression on the thymocytes was more severe with slower recovery as compared with that after single radiation injury only. The suppression on the splenocytes as a whole was similar to that after single radiation injury , but in the early stage after combined injury, the suppression was far more severe than that after radiation Escharectomy and skin grafting on the burn wounds on the lst day after combined injury could accelerate the recovery on both the thymocytes and splenocytes. Our findings indicated that the severity of the suppression on the immune functions due to combined radiation-burn injury might depend on the size of the burn wounds.4|5|1Updated：2024-04-10
- Abstract：Autoantibodies in systemic lupus erythematosus which cross-react with double stranded DNA and intermediate filament proteins are frequently reported. However, little is Known about the origin and the target of these antibodies. In this paper, a polyspecific monoclonal antibody, XY12, produced by the immunization of genetically non-autoimmune mice with a DNA-protein complex is detailed. Its antigen binding patterns are very similar to the autoantibodies. The data suggest that these autoantibedies may be triggered by a circulating nucleoprotein.4|19|0Updated：2024-04-10
- Abstract：Polymerase chain reaction （PCR） was used to detect the presence of Barrelia burgdoferi DNA in biological samples from patients with sarcoidosis. The target DNA sequence was of chromosomal origin. The amplified DNA sequence was analyzed by agarose gel electrophoresis, PAGE with silver staining, and the identity of amplified DNA was confirmed by restriction enzyme cleavage and DNA-DNA hybridization with a 32P-labelled probe. The assay was sensitive to fewer than two copies of B. burgdorferi genome, even in the presence of a 104-fold excess of human eukaryotic DNA , and was also specific to different B. burgdorferi strains tested. Sera serologically positive to B. burgdcrferi （n=26）, bronchoalveolar lavage fluid and supernatant of BALF （n=26） and peripheral blood （n=9） from sarcoidosis patients were tested. The positive rate was low （4/26, 2/26. and 0/9, respectively）. It was considered that DNA from B. burgdor ferimay be identified in a minority of patients with sarcoidosis, and it may play a pathogenetic role in such cases. More studies need to be done before advancing the hypothesis of an etiologic role of B. burgdorferi in sarcoidosis.4|8|1Updated：2024-04-10
- Abstract：For further reaseach on endovascular embolization treatment of AVMs, 54 patients with AVMs treated with embolization were observed. It was found that embolization was an effective procedure for the treatment of AVMs. Combined treatment of AVMs with presurgical embolization and direct surgery could reduce the comphcations resulting from large and high flow AVMs with lone surgical removal.4|17|0Updated：2024-04-10
- Abstract：Two hundred and sixty-two patients with carpal tunnel syndrome （CTS） were analyzed retrospectively. Results showed that middle-and older-age women were more apt to have CTS than men, and that the dominant hand was more frequently affected. Hormonal changes , repetitive and forceful movements, awkward positions of hand and wrist, and other factors may be associated with CTS. Typical clinical manifestations include pain and paresthesia in the median nerve territory, worsening at night or in the early morning , and being relieved by shaking the hand. Although the patients may localize the discomfort beyond the territory, sensory changes are variable and not entirely reliable. Conduction abnormalities often appeared selectively in the median nerve distal to the wrist in CTS. If the patient who is clinically suggestive of CTS shows normal conduction with conventional methods, palmar stimulation and inching technique is recommended. The diagnosis of CTS requires confirmation of illness history, symptoms and signs with objective electrodiagnostic tests.4|15|1Updated：2024-04-10
- Abstract：feet with hallux valgus among 40 patients treated by reconstruction of metatarsal arch and modified McBride operation are reported in this paper. After an average of 4. 5 years of postoperative follow-up, the results showed an overll 9° and 3° correction of the hallux abductus angle and the intermetatarsal angle, respectively. 95% of the cases of bunions disappeared, 66% calli under the heads of the first and second metatarsal disappeared, and 9l% patients were satisfied with the changes of their feet appearance.4|13|0Updated：2024-04-10
- Abstract：In this paper the results of skeletal traction and irrigation therapy （STIT） used for open fracture complicated with large-sized full-thickness skin-deficit and infection wounds （OFIW） were presented. Fourteen patients of OFIW were treated by the plaster cast and wound dressing （PCWD）, and 30 patients of OFIW were treated by STIT. The results indicated that after one week of treatment, the white blood cell count in the STIT group, compared to 17. 6±l. 0×109/L from before treatment, returned to 8. 8±0. 8×109/L,and in contrast, the cell count of the PCWD group was about 13. 0±1. 4×109/L. All of wound exudate culture in the STIT group was negative, and those of 7 cases （7/14） in PCWD group were positive （P<0. 0l）. The symptoms and signs such as pain, fever and septic exudate on the wound in the STIT group were much milder than those in the PCWD group. There were 5 cases （35. 7%） of toxicemia and septicemia, 2 cases （14. 3%） of osteomyelitis, 2 cases （14. 3 %） of amputation, 1 case （7. 1%） of delayed union and 3 cases （21. 4 %） of malunion in the PCWD group, and no complications in the STIT group.4|7|0Updated：2024-04-10
- Abstract：A three-dimensional finite element model of the lumbar motion segment was used to predict the stress distribution in lumbar spine with posterior element resection. It was shown that the stress level in all parts of the lumbar spine was elevated although the stress distribution remained unchanged. The authors concluded that the posterior element resection in lumbar surgery should be avoided as much as possible.4|12|0Updated：2024-04-10
- Abstract：A case of atypical hyperkalemic periodic paralysis is reported. The diagnosis was confirmed by hyperkalemic test, cold water test, and differentiation of attack period and rest period by the measurement of motor nerve conduction amplitude. Etio-pathology of this disease is discussed from the view of neuroelectrophysiology.4|11|0Updated：2024-04-10
- Abstract：The postmortem examination of a 59-year-old man who had suffered from acute abdominal pain for two days revealed that the cause of death was peritonitis secondary to perforated peptic ulceration. During examination,it was found that the urinary tract was abnormal. Here, we report a postmortem finding of aplastic renal dysplasia of the kidney and malformation of the urinary tract.4|6|0Updated：2024-04-10
- Abstract：ＡｐｐｌｉｃａｔｉｏｎｏｆＦｌｏｗＣｙｔｏｍｅｔｒｙｉｎＤｉａｇｎｏｓｉｓｏｆＨｙｄａｔｉｄｉｆｏｒｍＭｏｌｅｓＧｕｏＬｉｎａ；ＴａｎｇＭｉｎｙｉａｎｄＺｈｕＬｉｐｉｎ郭丽娜，唐敏一，朱立平(ＩｎｓｔｉｔｕｔｅｏｆＢａｓｉｃＭｅｄｉｃａｌＳｃｉｅｎｃ...4|17|0Updated：2024-04-10
- Abstract：ＩｎｔｒａｃｅｒｅｂｒａｌＣａｌｃｉｆｉｃａｔｉｏｎｉｎＨｙｐｅｒｐａｒａｔｈｙｒｏｉｄｉｓｍｄｕｅｔｏＡｎｔｉｅｐｉｌｅｐｔｉｃＤｒｕｇｓ￥ＳｏｎｇＦｅｎｇｓｈｅｎｇａｎｄＹａｏＦｕｍｉｎ宋峰生，姚福民(５６０１６Ｈｏｓｐｉｔａｌ．Ｌｅｓｈａｎ，Ｓ...4|4|0Updated：2024-04-10
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Effect of Hypertonic Saline on Pulmonary Diffusion Function in Hemorrhagic Shock under Acute Hypoxia
Abstract：ＥｆｆｅｃｔｏｆＨｙｐｅｒｔｏｎｉｃＳａｌｉｎｅｏｎＰｕｌｍｏｎａｒｙＤｉｆｆｕｓｉｏｎＦｕｎｃｔｉｏｎｉｎＨｅｍｏｒｒｈａｇｉｃＳｈｏｃｋｕｎｄｅｒＡｃｕｔｅＨｙｐｏｘｉａＺｈｏｕＱｉｑｕａｎ；ＺｈｉＤｏｎｇｘｕｅａｎｄＧａｏＬｉｊｕ周其全，支东学...4|8|0Updated：2024-04-10 - Abstract：ＥｆｆｅｃｔｓｏｆＭａｇｎｅｓｉｕｍｏｎＶｅｎｔｒｉｃｕｌａｒＤｅｆｉｂｒｉｌｌａｔｉｏｎＴｈｒｅｓｈｏｌｄａｎｄＰｏｓｔ－ｓｈｏｃｋＣｅｌｌｕｌａｒＥｌｅｃｔｒｏｐｈｙｓｉｏｌｏｇｉｃａｌＣｈａｎｇｅｓｉｎＨｅａｒｔｓＸｉａＱｉａｎｇ；ＷａｎｇＨａ...4|12|0Updated：2024-04-10
- Abstract：ＰｒｅｌｉｍｉｎａｒｙＳｔｕｄｉｅｓｏｎｔｈｅＥｆｆｅｃｔｓｉｎｔｈｅＡｇｅｄｔｏｔｈｅＭｅｔａｂｏｌｉｓｍｏｆＤｉａｚｅｐｉｎｅｓｉｎＶｉｖｏ￥ＴｉａｎＨｕｉｍｉｎ；ＹａｎｇＱｉａｎｇａｎｄＬｉｕＹｉｈｕａ田慧敏，杨强，刘毅华(Ｄｅｐａｒｔｍｅｎｔ...4|6|0Updated：2024-04-10
- Abstract：ＴｈｅＩｎｔｅｒｎａｔｉｏｎａｌＤｉａｂｅｔｅｓＳｙｍｐｏｓｉｕｍｗｉｌｌｈｅｈｅｌｄｒｏｍＮｏｖｅｍｂｅｒ１ｔｏ３，１９９５ｉｎＢｅｉｊｉｎｇ，Ｃｈｉｎａ，ＴｈｉｓｍｅｅｔｉｎｇｉｓｏｒｇａｎｉｚｅｄｂｙＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＭｅｄｉｃａ...4|7|0Updated：2024-04-10
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