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Volume ， Issue 2 ， 1996
- Abstract：The effect of intrathecal injection of dynorphin A （1-17） on second messenger systems of spinal cord relative to behavioral change in rats was studied. Dynorphin A （1-17） 5 ,10 （20nmol） caused dose-dependent flaccid paralysis of hindlimbs. Dynorphin A （1-17） 10, 20 nmol dose-dependently decreased spinal adenylate cyclase （AC） activity, cyclic AMP production, calmodulin （CaM） level and cyclic-nucleotide phosphodiesterase（PDE）activity 10 min after intrathecal injection. They recovered to a varying extent two hours later. Pretreatment with selective κ-opioid receptor antagonist nor-BNI 30 nmol 10 min before dynorphin A （1-17） markedly antagonized the effects of dynorphin A （1-17 ） at 20 nmol on hindlimb paralysis and inhibition of intracellular second messengers. The L-type calcium channel blocker verapamil （100nmol） also played a role in blocking dynorphin neurotoxicity. The NMDA receptor antagonist APV could partially or completely block dynorphin inhibition of CaM level and PDE activity without affecting paralysis and decrease of AC-cAMP level induced by dynorphin A（1-17） 10 min after intrathecal injection.6|7|0Updated：2024-04-10
- Abstract：ＴｈｅＤｉａｇｎｏｓｔｉｃＶａｌｕｅｏｆＲａｄｉｏｇｒａｐｈｉｃＭｅａｓｕｒｅｍｅｎｔｏｆｔｈｅＭｅｔａｃａｒｐａｌｔｏＳｅｎｉｌｅＯｓｔｅｏｐｏｒｏｓｉｓＤａｉＬｉｙａｎｇ；（戴力扬），ＣｈｅｎＤｅｙｕ；（陈德玉）ＷｕＤｅｓｈｅｎｇ；（吴德升）ａｎ...4|17|0Updated：2024-04-10
- Abstract：Purpose. To investigate the peak latency of the orbital presaccadic spike potential （SP） with horizontal eye movement in normals.Methods. Orbital SP was recorded in 28 normal subjects from 8 electrodes around the eyes with Pz as the reference while performing 5°, 10°, 20°, 30° and 40°horizontal saccades to visual targets. SP peak latency was measured from SP onset to SP peak on averaged data aligned on SP peak.Results. Significant main effects on SP peak latency are found for saccade size （<0. 01）, saccade direction （P<0. 01） and electrode site （P<0. 05）. No significant main effect on SP peak latency is found for eye （P>0. 05）. SP peak latency increases with increasing saccade size from 5°to 40°. SP peak latency is longer with saccades back to center than away from center, and with abducting saccades than with adducting saccades. SP peak latency differs at the electrode sites with an order from shorter to longer as follows: inner canthus （IC）; inferior orbit （IO）: outer canthus （OC）; superior orbit （SO）.Conclusicos. The effects on the peak latency of orbital SP can be explained by the saccade dynamic property, volume conduction as well as physiologic and anatomic factors of the eyes and orbits. The peak latency of orbital SP can be used to reflect the temporal characteristics of ocular motor units controlling saccadic eye movement.4|3|0Updated：2024-04-10
- Abstract：The vagus is a mixed nerve containing cholinerrgic and non-cholinergic neurons. Vagal fibers interact with peptidergic neurons of the enteric nervous system which stain immunohistochemically for cholecystokinin, vasoactive intestinal polypeptide, and gastrin releasing peptide. The contribution of these peptidergicneurons in the pancreatic response to vagal stimulation is unknown. We tested the effect of specific inhibitor of these stimulants against vagally mediated exocrine secretion in rats. The response to vagal stimulation was blocked significantly by each of the following:the ganglionic blocker hexamethonium （l00% inhibition）; the muscarinic, cholinergic blocker atropine （85% inhibition）; the specific cholecystokinin-A receptor blocker （91 % inhibition）; and a vasoactive intestinal polypeptide polyclonal antibody （89% inhibition）. This observation is consistent with the hypothesis that potentiating interactions among several agonists mediate the vagal response. Our study, however, dose not exclude acetylcholine as the final commommediator.4|12|0Updated：2024-04-10
- Abstract：Plasma concentrations of endothelin in bloor from the femoral vein and the antecubital vein were measured in 35 patients with mitral stenosis and heart failure before and after percutaneous balloon mitralvalvuloplasty（PBMV）. The basal plasma concentrations of endothelin in blood from the antecubirtal vein in the patients were significantly higher than those in 32 control subjects （15. 40± 3. 32 vs. 9. 59± 2. 66 pg/ml, P<0. 001）. Plasma endothelin concentrations in patients in New York Heart Association functional classes Ⅱ and Ⅲ were significantly higher than those in control subjects, respectively. The concentrations of endothelin in patients with atrial fibrillation were also significantly higher than those in patients with normal sinus rhythm. Ten to fifteen minutes after PBMV, plasma endothelin concentrations in blood from the femoral vein significantly decreased from 16. 14 ± 3. 34 to 13. 74 ± 3. 78 pg/ml （P<0. 01 ）. Seventy-two hours after the procedure, the concentrations of endothelin in blood from the antecubital vein had fallen to 12. 31 ± 2. 55 pg/ml （P<0. 001 vs. before PBMV and control subjects）. Plasma endothelin concentrations still tended to be higher in patients with atrial fibrillation than those in normal sinus rhythm, but the difference did not reach statistical significance. There were weak but significantly correlations of plasma endothe lin concentrations with the mean left atrial pressure （r= 0. 424 , P < 0.001 ）, mean right atrial pressure （r=0. 323, P<0. 01）, mean transmitral pressure gradient （r= 0. 397, P<0. 001）, heart rate （r= 0. 350,P<0. 005）and mitral valve area （r=-0. 454, P<0. 001） in the patients before and after PBMV.4|6|3Updated：2024-04-10
- Abstract：In this experiment, expression of tissue-type plasminogen activator （t-PA） in smooth muscle cells （SMCs） was measured at different intervals after the arterial injury. In the normal iliac arteries, only low levels of t-PA activity were estimated. t-PA activity in extracts of the iliac arteries increased significantlyat the 4th day after the injury, equivalent to the process that SMCs migrated from the media to the intima,and the t-PA activity was then decreased approximately to the normal level at the 7th day. Coexistent to the above data, results from in situ hybridization showed that the expression of t-PA mRNA in the intima as well as media increased also significantly at the 4th day after the arterial injury, and at the 7th day, tPA mRNA was detected only in those SMCs locating closely adjacent to the internal elastic lamina. These results suggest that t-PA might play an important role in SMC migration following endothelial injury, andantagonism of t-PA expression and/or activity within the vessel wall might be helpful in intervening the de velopment of restenosis following angioplasty.4|7|0Updated：2024-04-10
- Abstract：The effect of verapamil on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3 （ CVB3）-RNA replication in cultured neonatal rat heart cells infected with CVB3 was investigated. It was found that the Ca2+ influx could be inhibited significantly （P<O. 01） by verapamil （1 μmol/L） after infection of heart cells for 48h. However, when the cultured heart cells infected with CVB3 and treated with verapamil （Iμmol/L and 10 nmo/L） at the same time for 48h, the amounts of CVB3-RNA in myocytes were significantly higher than that in infected control group （P<O. 05）. These phenomena suggest that the increase of Ca2+ influx of cultured heart cells infected with CVB3 could be inhibited by some calcium antagonists, e. g. verapamil at the early stage. On the other hand, verapamil might accelerate viral replication in myocardium. Thus, although verapamil could be beneficial for decreasing the secondary Ca2+ damages and improve the myocardial electric activity, it isn’t a sensible choice for therapy in early stage of virus infection with cardiac symptoms.4|8|2Updated：2024-04-10
- Abstract：ＰｒｅｄｉｃｔｉｏｎｏｆＢｌｏｏｄＡｃｉｄ－ＢａｓｅＳｃａｌｅｔｏｔｈｅＳｕｓｃｅｐｔｉｂｌｅＰｏｐｕｌａｔｉｏｎｗｉｔｈＡｃｕｔｅＭｏｕｎｔａｉｎＳｉｃｋｅｎｅｓｓＺｈｏｕＱｉｑｕａｎ；（周其全）ａｎｄＹａｎｇＪｉｎｇｙｉ；（杨景义）(Ｌａｎｚｈｏ...4|5|0Updated：2024-04-10
- Abstract：Mongolian gerbils were used as delayed neuronal damage (DNDi animal models. At the end of 15Abstract:Mongolian gerbils were used as delayed neuronal damage （DND）animal models. At the end of 15 minute cerebral ischemia and at various reperfusion time ranging from 1 to 96 hours, the content of water and arginine vasopressin （AVP） in the CA1 sector of hippocampus were measured by the specific gravity method and radioimmunoassay. Furthermore, we also examined the effect of intracerebroventricular （ICV） injection of AVP, AVP antiserum on calcium, Na+, K+-ATPase activrty in the CA1 sector after ischemia and 96 hour reperfusion. The results showed that AVP contents of CA1 sector of hippocampus during 6 to 96 hour recirculation, and the water content of CA1 sector during 24 to 96 hour were significantly and continuously increased. After ICV inJection of AVP, the water content and calcium in CA1 sector of hippocampus at cerebral ischemia and 96 hour recirculation further increased, and the Na+, K+- ATPase activity in CA1 sector was remarkably decreased as compared with that of control. While ICV injection of AVP antiserum, the water content and calcium in CA1 sector were significantly decreased as com pared with that of control. These suggested that AVP was involved in the pathophysiologic process of DND in hippocampus following cerebral ischemia and reperfusion. Its mechanism might be through the change of intracellular action mediated by specific AVP receptor to lead to Ca ions over-load of neuron and inhibit the Na+, K+- ATPase activity , thereby to exacerbate the DND in hippocampus.4|15|0Updated：2024-04-10
- Abstract：Human bone morphogenetic protein 2A （hBMP2A） cDNA terminal 567 nucleotides were cloned and expressed in a phage display vector pCSM21. Human BMP2A C-terminal peptide displayed on the surface of the phage can bind specifically to the surface of mouse osteoblastic cell （MC3T3） membrane. ELISA assay showed a positive signal of the binding by using antibody against M13 phage gene 8 protein. After labeling with 3HTdR,the counts of the binding groups were 3 to 10 times higher than the control groups. It suggests that the surface of MC3T3 cells exist the receptor for hBMP2A.4|6|1Updated：2024-04-10
- Abstract：Polymerase chain reaction （PCR） has been applied in diagnosing amebic liver infection by detecting pathogenic Entamoeba histolytica DNA in liver aspirates. Oligonucleotide primers found to be specific for the gene encoding the 30 kDa molecule of this pathogenic ameba were used in the test. Liver aspirates obtained from 23 patients with amebic liver abscess substantiated by typical clinical manifastation or with very high titres of anti-E histolytica antibedies by ELISA were found to be positive by PCR. Fourteen control samples （3 cases of bacterial liver abscess, I of liver cancer and 10 of other abscess） were all found to be negative to this reaction- The results suggested PCR to be a specific and sensitive tool for diagnosing amebic liver abscess infections.4|5|0Updated：2024-04-10
- Abstract：The Dandy-Walker syndrome （DWS） can be accurately diagnosed in utero by sonographic demonstration of characteristic morphologic changes of the fetus, which includes hydrocephalus, incomplete cerebellar vermis and a posterior fossa cyst. We present a case of Dandy-Walker syndrome diagnosed antenatally. The assoiacted anomalies are reviewed, and the value of antenatal diagnosis is discussed.4|29|0Updated：2024-04-10
- Abstract：The expression of c-erbB-1 and c-erbB-2 oncogenes were investigated by immunohistochemistry using monoclonal antibodies to c-erbB-2 and c-erbB-2 protein in 43 cases of basal cell carcinoma （BCC） and 26 cases of squamous cell carcinoma （SCC）. We found that the expression of c-erbB-1 oncogene in all BCC increased by different degrees and the expression of c-erbB-2 oncogene in BCC was significantly reduced or lost when compared to that in normal epidermal cells. Furthermore, apparent negative and positive rela-tionships were observed respectively between the tumor differentiation and the expression of cerbB-1 and c-erbB-2 oncogenes in SCC. It is suggested that the abnormal expression of c-erbB-1 and c-erbB-2 oncogenes in BCC and SCC may play a role in the development of skin tumors. The pattern of the c-erbB-1 and c-erbB-2 oncogenes expression in SCC may assist in distinguishing the biological behavior and prognosis of SCC.4|15|3Updated：2024-04-10
- Abstract：HuPBLSCID mice were used to explore how they would response to human tumor cells of 80llMLC.Living 80llMLC cells appeared to be fetal to the the mice due to the production of human TNF- The hupBL-SCID mice did not generate any noticeable amount of specific human immunoglobulin either by single immunization with living 801/MLC cells or by repeated immunization with irradiated 80llMLC cells. Our preliminary experiments with huPBL-SCID mice showed that such chimeras would be a very useful models for tumor immunological researches.4|15|0Updated：2024-04-10
- Abstract：This paper reports a familial amyloid polyneuropathy （FAP） family in China. This family being investigated had 69 members of five generations. From the third generation, there have been 16 patients. The age of onset was about 3 to 5 decades. The initial symptoms were autonomic nerve symptoms, such as impotence, dyspepsia and diarrhoea, associated with the sensory loss of lower extremities. As the disease progressed, the upper extremities and motor ability were also involved. The duration of disease course was about 8-10 years, most patients died of infection and cachexia. Sural biopsy in 3 patients had showed positive Congo red staining. From the clinical view, this FAP family is similar to FAP I found in Japan. The true classification, however, should be confirmed by further genetic analysis.4|10|1Updated：2024-04-10
- Abstract：ＤｅｔｅｒｍｉｎａｔｉｏｎｏｆＳｅｒｕｍＯｓｔｅｏｃａｌｃｉｎｉｎＭｉｄｄｌｅａｎｄＥｌｄｅｒｌｙＡｇｅｄＨｅａｌｔｈｙＳｕｂｊｅｃｔｓＺｈｕＪｉａｎｚｈｏｎｇ；（朱建中）ａｎｄＧｅＷｅｉ；（葛炜）(ＨａｎｇｚｈｏｕＳａｎａｔｏｒｉｕｍｏｆＰＬＡ，Ｈ...4|4|0Updated：2024-04-10
- Abstract：Radiographic measurements was performed on 124 normal adults for anterior, posterior and middle heights of the vertebral bodies in thoracic and lumbar spine. The normal ratios of vertebral height in one vertebral body and one with the adjacent bodies were presented. The method for measurement and its diagnostic value to osteoporotic vertebral fractures were discussed.4|21|1Updated：2024-04-10
- Abstract：This paper presents 5 patients with repeated recurrence of osteosarcoma （RROS）. The primary focus of 3 patients were in the distal portion of femur, and 2 patients were in the proximal Portion of tibia. Three patients, whose chest X ray film were negative, were treated by amputation and chemotherapy. Two patients had isolated metastatic focus l. 5 cm in diameter in lung, were treated by amputation after 1 week of chemotherapy and then treated by lobectomy after 2 weeks of chemotherapy. After operation, the chemotherapy was carried out for 3 courses of treatment. The roentgenogram of chest and affected limb were taken once every two months. There were metastatic focuses found in the lung of 1 patient and in the distal portion of femur of 2 patients. One patient was operated on for 4 times. UP to now, 3 patients have been living for 5 yeara and 2 patients for 6 years after operation.4|4|0Updated：2024-04-10
- Abstract：ＰｒｏｇｎｏｓｔｉｃＶａｌｕｅｏｆＳｉｌｖｅｒ－ｓｔａｉｎｅｄＮｕｃｌｅｏｌａｒＯｒｇａｎｉｚｅｒ Ｒｅｇｉｏｎｓ（Ａｇ－ＮＯＲｓ）ｉｎＣｏｌｏｒｅｃｔａｌＣａｒｃｉｎｏｍａＺｈｏｕＺｅｎｇｆｅｎ；（周曾芬）ａｎｄＹｕａｎＳｈｉｚｈｅｎ；（袁世珍）Ｇ...6|3|0Updated：2024-04-10
- Abstract：ＣｏｎｔｒｉｂｕｔｉｏｎｏｆＥｎｄｏｔｈｅｌｉｎｔｏＶｅｎｔｒｉｃｕｌａｒＲｅｍｏｄｅｌｉｎｇｉｎＭｙｏｃａｒｄｉａｌＩｎｆａｒｃｔｅｄＲａｂｂｉｔｓＨｅＺｈｅｎｓｈａｎ；（何振山），ＮｉｎｇＰｅｉｙｕ；（宁佩萸），ＷｕＧｕａｎｇｌｉ；（吴广礼），Ｚ...4|5|0Updated：2024-04-10
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Observations on Adrenocortical Function of Rapid Entry Population to Plateau （Analysis of 534 Cases）
Abstract：ＯｂｓｅｒｖａｔｉｏｎｓｏｎＡｄｒｅｎｏｃｏｒｔｉｃａｌＦｕｎｃｔｉｏｎｏｆＲａｐｉｄＥｎｔｒｙＰｏｐｕｌａｔｉｏｎｔｏＰｌａｔｅａｕ（Ａｎａｌｙｓｉｓｏｆ５３４Ｃａｓｅｓ）ＹａｎｇＪｉｎｇｙｉ；（杨景义）ａｎｄＺｈｏｕＱｉｑｕａｎ；（周其全）(Ｌａ...6|4|0Updated：2024-04-10 - Abstract：ＴｈｅＥａｒｌｙＰｏｓｔｏｐｅｒａｔｉｖｅＨｙｐｏｘｅｍｉａｉｎＩｎｆａｎｔｓ，ＣｈｉｌｄｒｅｎａｎｄＡｄｕｌｔｓＸｕｅＦｕｓｈａｎ；（薛富善），ＬｕｏＬａｉｋｕｉ；（罗来葵），ＬｉｕＱｉｎｇｈｕａ；（刘青华），ＬｉａｏＸｕ；（廖旭）ＴｏｎｇＳｈｉｙ...4|3|0Updated：2024-04-10
- Abstract：ＳｔｕｄｉｅｓｏｎＩｍｍｕｎｏｔｈｅｒａｐｙａｇａｉｎｓｔＭｅｌａｎｏｍａｉｎ ＭｉｃｅＵｓｉｎｇＩＬ２Ｇｅｎｅ－ＴｒａｎｓｆｅｃｔｅｄＢ１６ＭｅｌａｎｏｍａＶａｃｃｉｎｅＣｏｍｂｉｎｅｄｗｉｔｈＳｐｅｃｉｆｉｃＣＴＬＣｅｌｌｓＮｉｕＧｕｉｌｉａｎ；...4|9|0Updated：2024-04-10
- Abstract：ＴｈｅＨｅｍｏｄｙｎａｍｉｃＲｅｓｐｏｎｓｅｔｏｔｈｅＤｏｕｂｌｅＣｈａｍｂｅｒＩｎｔｒａ－ａｏｒｔｉｃＢａｌｌｏｏｎＰｕｍｐｉｎｇＬｕＳｏｎｇｆａｎｇ；（陆颂芳）ＢａｏＹｕｓｈｅｎｇ；（包玉生）ＰｅｎｇＹｉ；（彭屹），ＷａｎｇＣｈｕｎｒｅｎ；(王春...4|8|0Updated：2024-04-10
- Abstract：Ｄｅｔｅｃｔｉｏｎｏｆ７３ＫｉｎｄｓｏｆＨＬＡ－ＤＲＢＡｌｌｅｌｅｓｂｙ２９ＫｉｎｄｓｏｆＰｒｏｂｅｓＫｅＢｉｎｇｓｈｅｎ；（克丙申），ＳｈａｎｇＪｉｄｏｎｇ；（尚继栋），ｅｔａｌ．(ＤｅｐａｒｔｍｅｎｔｏｆＩｍｍｕｎｏｌｏｇｙ，ＪｉｎａｎＭｉｌｉｔ...4|3|0Updated：2024-04-10
- Abstract：ＥｆｆｅｃｔｓｏｆＥｐｉｄｕｒａｌＢｌｏｃｋｓｏｎｔｈｅＰｕｌｓｅＯｘｉｍｅｔｅｒＤｅｔｅｃｔｉｏｎＴｉｍｅＸｕｅＦｕｓｈａｎ；（薛富善），ＬｉａｏＸｕ；（廖旭），ＴｏｎｇＳｈｉｙｉ；（佟世义），ＡｎＧａｎｇ；（安刚），ａｎｄＬｕｏＬａｉｋｕｉ；(罗...4|10|0Updated：2024-04-10
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