Confounding Effect in Clinical Research of Otolaryngology and Its Control

Yu Yong-qiang; Huang Dong-yan; Armijo Olivo Susan; Yang Huai-an; Bambanini Yagesh; Sonnenberg Lyn; Clark Brenda; Constantinescu Gabriela; Qian Yu Jason; Zhang Ming

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Confounding Effect in Clinical Research of Otolaryngology and Its Control

中国医学科学杂志（英文版） 2015年30卷第2期页码：121-130

Review | Updated：2024-04-10

- Confounding Effect in Clinical Research of Otolaryngology and Its Control
- Affiliations：
  
  1. 1Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB T6G 2G4, Canada
  2. 2Department of Otorhinolaryngology Head and Neck Surgery, Clinical Division of Surgery, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
  3. 3Research Center, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB T6G 2G4, Canada
  4. 4Department of Otolaryngology, the First Affiliated Hospital, China Medical University, Shenyang 110001, China
  5. 5Department of Occupational Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB T6G 2G4, Canada
  6. 6Department of Developmental Pediatrics, Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada
  7. 7Institute for Reconstructive Science in Medicine, Edmonton, AB T5R 4H5, Canada
  8. 8Alberta School of Business, University of Alberta, Edmonton, AB T6G 2R6, Canada
  9. 9Department of Audiology, Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada
  10. 10Department of Surgery-Otolaryngology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
- Author bio：
  
  *Corresponding author E-mail: yyu2@ualberta.ca
- Funds：
- DOI：
  中图分类号：
- 收稿日期：2014-10-21，
  
  网络出版日期：2015-04-20，
  
  纸质出版日期：2015-04
- Accepted：
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Confounding Effect in Clinical Research of Otolaryngology and Its Control[J]. 中国医学科学杂志（英文版）, 2015,30(2):121-130.

Yu Yong-qiang, Huang Dong-yan, Armijo Olivo Susan, et al. Confounding Effect in Clinical Research of Otolaryngology and Its Control[J]. Chinese medical sciences journal, 2015, 30(2): 121-130.
Confounding Effect in Clinical Research of Otolaryngology and Its Control[J]. 中国医学科学杂志（英文版）, 2015,30(2):121-130. DOI：

Yu Yong-qiang, Huang Dong-yan, Armijo Olivo Susan, et al. Confounding Effect in Clinical Research of Otolaryngology and Its Control[J]. Chinese medical sciences journal, 2015, 30(2): 121-130. DOI：

摘要

Abstract

Confounding effect is a critical issue in clinical research of otolaryngology because it can distort the research’s conclusion. In this review

we introduce the definition of confounding effect

the methods of verifying and controlling the effect. Confounding effect can be prevented by research’s design

and adjusted by data analysis. Clinicians would be aware and cautious about confounding effect in their research. They would be able to set up a research’s design in which appropriate methods have been applied to prevent this effect.They would know how to adjust confounding effect after data collection. It is important to remember that sometimes it is impossible to eliminate confounding effect completely

and statistical method is not a master key. Solid research knowledge and critical thinking of our brain are the most important in controlling confounding effect.

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references

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