Impact of 1, 25-(OH)2D3 on Left Ventricular Hypertrophy in Type 2 Diabetic Rats△

Fan Ying; Zhang Shan-xiao; Ren Meng; Hong Li-feng; Yan Xiao-ni

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Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△

中国医学科学杂志（英文版） 2015年30卷第2期页码：114-120

Original Articles | Updated：2024-04-10

- Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△
- Affiliations：
  
  1. 1Department of Cardiology, the Fifth Hospital of Wuhan & Institute of Cardiovascular Sciences of Jianghan University, Wuhan 430050, China;
  2. 2Department of Cardiology, the First Hospital of Yangtze University,Jingzhou, Hubei 434000, China
- Author bio：
  
  * Corresponding author Tel: 86-27-84812640, E-mail: leefenghong@gmail.com
- Funds：
  
  △Supported by the Research Fund for Public Health of the Health and Family Planning Commission of Wuhan Municipality (WG13B12).
- DOI：
  中图分类号：
- 收稿日期：2014-02-12，
  
  网络出版日期：2015-04-20，
  
  纸质出版日期：2015-04
- Accepted：
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Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△[J]. 中国医学科学杂志（英文版）, 2015,30(2):114-120.

Fan Ying, Zhang Shan-xiao, Ren Meng, et al. Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△[J]. Chinese medical sciences journal, 2015, 30(2): 114-120.
Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△[J]. 中国医学科学杂志（英文版）, 2015,30(2):114-120. DOI：

Fan Ying, Zhang Shan-xiao, Ren Meng, et al. Impact of 1, 25-(OH)₂D₃ on Left Ventricular Hypertrophy in Type 2 Diabetic Rats^△[J]. Chinese medical sciences journal, 2015, 30(2): 114-120. DOI：

摘要

Abstract

Objective

To investigate the impact of 1

25-(OH)

on left ventricular hypertrophy (LVH) in type 2 diabetic rats.

Methods

Type 2 diabetic mellitus (DM) model rats were established by intraperitoneally injecting with 30 mg/kg streptozotocin. After 8 weeks

19 male rats were identified as diabetic with left ventricular hypertrophy (LVH) by ultrasound examination

and randomly assigned into three groups: untreated (DM-LVH

=7)

treated with insulin (DM-LVH+INS

=6)

and treated with 1

25-(OH)

(DM-LVH+VD

=6). Healthy male rats were used as the controls group (

=6). The fasting blood glucose and the insulin level were determined weekly. The left ventricular mass index

myocardial collagen content

collagen volume fraction

and 1

25-(OH)

-receptor level were determined by 4 weeks later.

Results

In the DM-LVH model group

the insulin level was significantly decreased compared with the non-diabetic control group (

0.05)

whereas the blood glucose

left ventricular mass index

myocardial collagen content

collagen volume fraction

and 1

25-(OH)

-receptor expression were significantly increased (all

0.05). In the DM-LVH+INS and DM-LVH+VD groups

the insulin levels were significantly increased compared with the DM-LVH model group (

0.05)

whereas the other parameters were significantly decreased (all

0.05).

Conclusion

25-(OH)

could reverse LVH in diabetic rats and that the mechanism may involve stimulating insulin secretion and reducing blood glucose

via

direct up-regulation of 1

25-(OH)

-receptor expression.

关键词

Keywords

references

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