Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study<sup>△</sup>

Tian Shu-bo; Yu Jian-chun; Kang Wei-ming; Ma Zhi-qiang; Ye Xin; Yan Chao; Huang Ya-kai

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Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△

中国医学科学杂志（英文版） 2015年30卷第2期页码：84-89

Original Articles | Updated：2024-04-10

- Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△
- Affiliations：
  
  Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  *Corresponding author Tel: 86-10-69152215, E-mail: yu-jch@163.com
- Funds：
  
  △Supported by Beijing Municipal Natural Science Foundation of China (7132209) and Special Found of the Capital Health Research and Deve- lopment (2014-3-4014).
- DOI：
  中图分类号：
- 收稿日期：2015-02-24，
  
  网络出版日期：2015-04-20，
  
  纸质出版日期：2015-04
- Accepted：
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Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△[J]. 中国医学科学杂志（英文版）, 2015,30(2):84-89.

Tian Shu-bo, Yu Jian-chun, Kang Wei-ming, et al. Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△[J]. Chinese medical sciences journal, 2015, 30(2): 84-89.
Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△[J]. 中国医学科学杂志（英文版）, 2015,30(2):84-89. DOI：

Tian Shu-bo, Yu Jian-chun, Kang Wei-ming, et al. Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study^△[J]. Chinese medical sciences journal, 2015, 30(2): 84-89. DOI：

摘要

Abstract

Objective

To evaluate the prognostic effects of neoadjuvant chemotherapy (NAC) in patients with local advanced gastric cancer.

Methods

We retrospectively analyzed prognosis in 191 patients with advanced gastric cancer

of whom 71 were treated with NAC and 120 received surgery only between February 2007 and July 2013. Postoperative complication rate was recorded. Survival by clinicopathological features

pathological T and N stages

and histopathological tumor regression was retrospectively compared between the two groups.

Results

According to Response Evaluation Criteria in Solid Tumors

none of the 71 patients in the NAC followed by surgery group showed complete response

36 showed partial response

25 had stable disease

and 10 had progressive disease. The chemotherapy response rate was 50.7%; the disease control rate was 85.9%. Grade 3/4 adverse events were seen in less than 20% patients

with acceptable toxicities. No difference was found in the overall postoperative complication rates between the two groups (7

versus

22 cases

=0.18). Median survival time was significantly different

at 54 months in the NAC combined with surgery group and 25 months in the surgery-only group (

=0.025).

Conclusion

In patients with operable gastric adenocarcinomas

NAC can significantly improve overall survival without increasing surgical complications.

关键词

Keywords

references

Siegel R , Naishadham D , Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013 ; 63 : 11 - 30 .

Ferlay J , Shin HR , Bray F , et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010 ; 127 : 2893 - 917 .

Shi WT , Wei L , Xiang J , et al. Chinese patients with gastric cancer need targeted adjuvant chemotherapy schemes. Asian Pac J Cancer Prev 2012 ; 13 : 5263 - 72 .

Eisenhauer EA , Therasse P , Bogaerts J , et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) . Eur J Cancer 2009 ; 45 : 228 - 47 .

Menges M , Hoehler T. Current strategies in systemic treatment of gastric cancer and cancer of the gastroesophageal junction. J Cancer Res Clin Oncol 2009 ; 135 : 29 - 38 .

Wu AW , Xu GW , Wang HY , et al. Neoadjuvant chemotherapy versus none for resectable gastric cancer . Cochrane Database Syst Rev , 2007 ; 18 : CD005047 .

Hartgrink HH , van de Velde CJ , Putter H , et al . Neo-adjuvant chemotherapy for operable gastric cancer: Long term results of the Dutch randomised FAMTX trial. Eur J Surg Oncol 2004 ; 30 : 643 - 9 .

Nio Y , Koike M , Omori H , et al. A randomized consent design trial of neoadjuvant chemotherapy with tegafur plus uracil (UFT) for gastric cancer—a single institute study. Anticancer Res 2004 ; 24 : 1879 - 87 .

Wang Y , Yu YY , Li W , et al. A phase Ⅱ trial of xeloda and oxaliplatin (XELOX) neo-adjuvant chemotherapy followed by surgery for advanced gastric cancer patients with para-aortic lymph node metastasis. Cancer Chemother Pharmacol 2014 ; 73 : 1155 - 61 .

Nashimoto A , Yabusaki H , Nakagawa S , et al. Preoperative chemotherapy with S-1 and cisplatin for highly advanced gastric cancer. Anticancer Res 2009 ; 29 : 4689 - 96 .

Cunningham D , Allum WH , Stenning SP , et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006 ; 355 : 11 - 20 .

Ychou M , Boige V , Pignon JP , et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: An FNCLCC and FFCD multicenter phase Ⅲ trial. J Clin Oncol 2011 ; 29 : 1715 - 21 .

Schuhmacher C , Gretschel S , Lordick F , et al. Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer randomized trial 40954. J Clin Oncol 2010 ; 28 : 5210 - 8 .

Xiong BH , Cheng Y , Ma L , et al. An updated Meta-analysis of randomized controlled trial assessing the effect of neoadjuvant chemotherapy in advanced gastric cancer. Cancer Invest 2014 ; 32 : 272 - 84 .

Xu AM , Huang L , Liu W , et al. Neoadjuvant chemotherapy followed by surgery versus surgery alone for gastric carcinoma: Systematic review and Meta-analysis of randomized controlled trials. PLoS One 2014 ; 9 : e86941 .

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