<italic style="font-style: italic">GSTT</italic>1纯合子缺失与胰腺癌风险关系的Meta分析

崔君鹏; 林美艺; 刘正昊; 刘宝林

doi:10.24920/003490

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GSTT1纯合子缺失与胰腺癌风险关系的Meta分析

中国医学科学杂志（英文版） 2019年34卷第3期页码：205-210

Original Article | Updated：2024-04-10

- GSTT1纯合子缺失与胰腺癌风险关系的Meta分析
- Affiliations：
  
  1. 1 Sixth Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
  2. 2 Department of Rheumatology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  3. 3 China Medical University, Shenyang 110013, China
- Author bio：
  
  *E-mail: liubl@sj-hospital.org
- Funds：
- DOI：10.24920/003490
  中图分类号：
- 收稿日期：2018-12-20，
  
  网络出版日期：2018-04-18，
  
  纸质出版日期：2019-08-26
- Accepted：
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崔君鹏, 林美艺, 刘正昊, 等. GSTT1纯合子缺失与胰腺癌风险关系的Meta分析[J]. 中国医学科学杂志（英文版）, 2019,34(3):205-210.

Cui Junpeng, Lin Meiyi, Liu Zhenghao, et al. Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis[J]. Chinese medical sciences journal, 2019, 34(3): 205-210.
崔君鹏, 林美艺, 刘正昊, 等. GSTT1纯合子缺失与胰腺癌风险关系的Meta分析[J]. 中国医学科学杂志（英文版）, 2019,34(3):205-210. DOI： 10.24920/003490.

Cui Junpeng, Lin Meiyi, Liu Zhenghao, et al. Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis[J]. Chinese medical sciences journal, 2019, 34(3): 205-210. DOI： 10.24920/003490.

摘要

目的

探讨

GSTT

1纯合缺失与胰腺癌易感性的关系。

方法

检索PubMed database

CNKI

EMBASE数据库（发表日期截至2018年4月18日）中评价

GSTT

1基因纯合子缺失与胰腺癌关系的研究。采用RevMan5.3和Stata12.0软件分析胰腺癌患者和健康对照发生

GSTT

1基因纯合子缺失的频率

并计算

值和95％置信区间（95%

）。

结果

共有9篇文献纳入此项Meta分析。共包括5952例受试者

其中胰腺癌患者2387例

健康对照3565例。与对照组相比

胰腺癌患者发生

GSTT

1纯合子缺失的频率更高（33.4%比38.7%

=1.26

95%

=1.01-1.58

=0.04）。

结论

GSTT

1纯合性缺失个体可能具有更高的胰腺癌易感性。

Abstract

Objective

To clarify the possible association of

GSTT

1 homozygous deletion with the susceptibility to pancreatic cancer.

Methods

We searched PubMed database

Chinese Journal Full Text Database (CNKI)

and EMBASE to find the eligible studies published up to April 18

2018 for evaluating the relationship between

GSTT

1 homozygous deletion and pancreatic cancer. The frequency of null genotype for

GSTT

1 between the pancreatic cancer group and the healthy control group was compared with

Chi

square

test

and odds ratios (

s) value and 95% confidence interval (95%

) were calculated.

Results

A total of 9 studies met the inclusion criteria

and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis. Compared with the control group

frequency of null genotype for

GSTT

1 in the pancreatic cancer group was higher (33.4%

. 38.7%

= 1.26

95%

= 1.01-1.58

= 0.04).

Conclusion

GSTT

1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.

关键词

Keywords

references

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GSTT1纯合子缺失与胰腺癌风险关系的Meta分析

DOI：10.24920/003490

摘要

Abstract

关键词

Keywords

references