氨甲环酸相关的急性心肌梗死：已发表病例回顾

姚允泰; 袁昕; 邵恳

doi:10.24920/003596

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氨甲环酸相关的急性心肌梗死：已发表病例回顾

中国医学科学杂志（英文版） 2020年35卷第1期页码：65-70

Original Article | Updated：2024-04-10

- 氨甲环酸相关的急性心肌梗死：已发表病例回顾
- Affiliations：
  
  1Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
  2Department of Adult Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
  3Department of Anesthesiology, Jingmen No. 1 People’s Hospital, Jingmen, Hubei 448000, China
- Author bio：
  
  * E-mail: yuntaiyao@126.com
- Funds：
- DOI：10.24920/003596
  中图分类号：
- 网络出版日期：2020-03-31，
  
  纸质出版日期：2020-01-20
- Accepted：
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姚允泰, 袁昕, 邵恳. 氨甲环酸相关的急性心肌梗死：已发表病例回顾[J]. 中国医学科学杂志（英文版）, 2020,35(1):65-70.

Yao Yuntai, Yuan Xin, Shao Ken. Acute Myocardial Infarction After Tranexamic Acid: Review of Published Case Reports[J]. Chinese medical sciences journal, 2020, 35(1): 65-70.
姚允泰, 袁昕, 邵恳. 氨甲环酸相关的急性心肌梗死：已发表病例回顾[J]. 中国医学科学杂志（英文版）, 2020,35(1):65-70. DOI： 10.24920/003596.

Yao Yuntai, Yuan Xin, Shao Ken. Acute Myocardial Infarction After Tranexamic Acid: Review of Published Case Reports[J]. Chinese medical sciences journal, 2020, 35(1): 65-70. DOI： 10.24920/003596.

摘要

目的

总结已发表的氨甲环酸（TXA）相关的急性心肌梗死（AMI）病例。

方法

我们在电子数据库中检索已发表的TXA治疗后的AMI病例

并分别提取入选病例的相关数据

包括患者AMI的临床表现、辅助检查、药物治疗史、AMI治疗结果及预后。

结果

最终检索出7篇已发表的TXA治疗后的AMI病例报道（共7例患者）

其中2篇来自美国

其余5篇分别来自印度、土耳其、英国、意大利和法国。7例患者中

年龄最轻者28岁

最长者77岁

5例为女性

2例为男性。4人接受TXA治疗系因外科出血、2例因月经出血、1例因咯血。7例患者AMI的诊断基于症状、ECG表现、心肌酶及冠状动脉造影。4例患者在确诊后接受了冠状动脉支架植入术、抗血小板及抗凝治疗等。在住院及随访期内

无死亡病例

7例均未发生其他重大的心血管事件。

结论

本文提示TXA与AMI可能相关。即便是栓塞低风险的患者

这种风险也值得重视。

Abstract

Objective

To summarize cases of acute myocardial infarction (AMI) after tranexamic acid (TXA) administration.

Methods

Electronic databases were searched to identify all case reports presenting AMI after use of TXA. Two authors independently extracted data of patients’ manifestation

examinations

medical history

treatment and outcome.

Results

Our search yielded seven case reports including seven patients. Among the seven reports

two were from USA

and the other five were from India

Turkey

Italy and France

respectively. Of the seven patients aged between 28- and 77-year-old who developed AMI after TXA

five patients were female and two were male. TXA was prescribed for four patients to reduce surgical bleeding

for two patients to treat menorrhagia and for one patient to manage hemoptysis. The diagnosis of AMI was made based upon patients’ symptoms

ECG

myocardium-specific enzymes

and confirmed by coronary angiography. Coronary stents were placed in four patients

for whom anti-platelet and anti-coagulation drugs were prescribed. No death or major cardiovascular events were reported during hospitalization and follow-up.

Conclusion

These case reports suggested a possible association of TXA administration and an increased risk of AMI

even in patients with relatively low thrombotic risk.

关键词

Keywords

references

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