聚氨酯人工血管生物材料表面改性的策略进展

黄怀谷; 向涛; 陈跃鑫

doi:10.24920/004178

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聚氨酯人工血管生物材料表面改性的策略进展

中国医学科学杂志（英文） 2023年38卷第4期页码：279-285

综述 | Updated：2024-05-21

- 聚氨酯人工血管生物材料表面改性的策略进展
- Affiliations：
  
  1. 1Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  2. 2Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China
- Author bio：
  
  *chenyuexin@pumch.cn
- Funds：
- DOI：10.24920/004178
  中图分类号：
- 收稿日期：2022-10-11，
  
  录用日期：2023-07-24，
  
  网络出版日期：2023-08-28，
  
  纸质出版日期：2023-12-30
- Accepted：
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黄怀谷, 向涛, 陈跃鑫. 聚氨酯人工血管生物材料表面改性的策略进展[J]. 中国医学科学杂志（英文）, 2023,38(4):279-285.

Huai-Gu Huang, Tao Xiang, Yue-Xin Chen. Current Strategies of Surface Modifications to Polyurethane Biomaterials for Vascular Grafts[J]. Chinese medical sciences journal, 2023, 38(4): 279-285.
黄怀谷, 向涛, 陈跃鑫. 聚氨酯人工血管生物材料表面改性的策略进展[J]. 中国医学科学杂志（英文）, 2023,38(4):279-285. DOI： 10.24920/004178.

Huai-Gu Huang, Tao Xiang, Yue-Xin Chen. Current Strategies of Surface Modifications to Polyurethane Biomaterials for Vascular Grafts[J]. Chinese medical sciences journal, 2023, 38(4): 279-285. DOI： 10.24920/004178.

摘要

血管转流术是矫治血管缺损或良性狭窄的重要手段。由于自体血管或同种异体血管的来源有限，因此，临床上将人工血管生物材料作为重要的移植替代物。由移植物引起的蛋白质、血小板和细菌黏附，造成的移植血管狭窄、血栓形成及术后感染是血管转流术的主要并发症。聚氨酯是一种常用的人工血管生物材料。为了抵抗由移植物引起的蛋白质、血小板和细菌黏附，促进内皮细胞黏附，研究人员对聚氨酯材料进行了一系列的表面改性，以降低移植后受者的血栓形成风险。本综述总结了聚氨酯人工血管生物材料的表面改性机制及其策略。

Abstract

As the number of patients suffering from cardiovascular diseases and peripheral vascular diseases rises

the constraints of autologous transplantation remain unavoidable. As a result

artificial vascular grafts must be developed. Adhesion of proteins

platelets and bacteria on implants can result in stenosis

thrombus formation

and postoperative infection

which can be fatal for an implantation. Polyurethane

as a commonly used biomaterial

has been modified in various ways to deal with the adhesions of proteins

platelets

and bacteria and to stimulate endothelium adhesion. In this review

we briefly summarize the mechanisms behind adhesions

overview the current strategies of surface modifications of polyurethane biomaterials used in vascular grafts

and highlight the challenges that need to be addressed in future studies

aiming to gain a more profound understanding of how to develop artificial polyurethane vascular grafts with an enhanced implantation success rate and reduced side effect.

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