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肠道微生物及其代谢产物对代谢相关性脂肪肝病发生发展的影响
- Affiliations：
1. 1Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease, Affiliated Nanhua Hospital, Hengyang Medical School & University of South China, Hengyang, Hunan 421002, China
2. 2Department of Gastroenterology, Affiliated Nanhua Hospital, Hengyang Medical School & University of South China, Hengyang, Hunan 421002, China
3. 3Department of Hepatobiliary Surgery, Affiliated Nanhua Hospital, Hengyang Medical School & University of South China, Hengyang, Hunan 421002, China
4. 4Department of General Practice, Affiliated Nanhua Hospital, Hengyang Medical School & University of South China, Hengyang, Hunan 421002, China
- Author bio：
*yxf009988@sina.com
- Funds：
DOI：10.24920/004220
中图分类号：收稿日期：2023-03-02，
录用日期：2023-08-12，
网络出版日期：2023-12-15，
纸质出版日期：2023-12-30
- Accepted：
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汪远远, 林海连, 王克浪, 等. 肠道微生物及其代谢产物对代谢相关性脂肪肝病发生发展的影响[J]. 中国医学科学杂志（英文）, 2023,38(4):286-296.
Yuan-Yuan Wang, Hai-Lian Lin, Ke-Lang Wang, et al. Influence of Gut Microbiota and its Metabolites on Progression of Metabolic Associated Fatty Liver Disease[J]. Chinese medical sciences journal, 2023, 38(4): 286-296.
汪远远, 林海连, 王克浪, 等. 肠道微生物及其代谢产物对代谢相关性脂肪肝病发生发展的影响[J]. 中国医学科学杂志（英文）, 2023,38(4):286-296. DOI： 10.24920/004220.
Yuan-Yuan Wang, Hai-Lian Lin, Ke-Lang Wang, et al. Influence of Gut Microbiota and its Metabolites on Progression of Metabolic Associated Fatty Liver Disease[J]. Chinese medical sciences journal, 2023, 38(4): 286-296. DOI： 10.24920/004220.
摘要
由于生活方式和饮食习惯的改变，代谢相关性脂肪肝已成为全球流行的慢性肝病。研究表明：肠道微生物群及其代谢产物在代谢相关性脂肪肝的发病机制中起着至关重要的作用。了解肠道微生物群及其代谢产物在代谢相关性脂肪肝中的功能有助于阐明病理机制、确定诊断标志物以及开发治疗药物或益生菌。在此，我们回顾了肠道微生物群及其代谢产物对代谢相关性脂肪肝的致病机理，并从肠道微生物的角度探讨治疗代谢相关性脂肪肝的可行性。
Abstract
Metabolic associated fatty liver disease (MAFLD) has become a prevalent chronic liver disease worldwide because of lifestyle and dietary changes. Gut microbiota and its metabolites have been shown to play a critical role in the pathogenesis of MAFLD. Understanding of the function of gut microbiota and its metabolites in MAFLD may help to elucidate pathological mechanisms
identify diagnostic markers
and develop drugs or probiotics for the treatment of MAFLD. Here we review the pathogenesis of MAFLD by gut microbiota and its metabolites and discuss the feasibility of treating MAFLD from the perspective of gut microbes.
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references
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