生玉米淀粉改善胰岛素瘤相关低血糖的疗效：一种有前景的支持治疗

Rong-Rong Li; Wei Chen; Xin-Hua Xiao; Miao Yu; Fan Ping; Lian Duan

doi:10.24920/004329

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生玉米淀粉改善胰岛素瘤相关低血糖的疗效：一种有前景的支持治疗

中国医学科学杂志（英文） 2024年39卷第2期页码：102-110

论著 | Updated：2025-03-07

- 生玉米淀粉改善胰岛素瘤相关低血糖的疗效：一种有前景的支持治疗
- Affiliations：
  
  1.Department of Clinical Nutrition, Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  2.Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  E-mail: txchenwei@sina.com
- Funds：
  
  the National High Level Hospital Clinical Research Fund(2022-PUMCH-A-146);the National Natural Science Foundation of China(72074222);the National Key Research and Development Program of China(2020YFC2005005)
- DOI：10.24920/004329
  中图分类号：
- 收稿日期：2023-12-11，
  
  录用日期：2024-04-11，
  
  网络出版日期：2024-05-17，
  
  纸质出版日期：2024-06-30
- Accepted：
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生玉米淀粉改善胰岛素瘤相关低血糖的疗效：一种有前景的支持治疗[J]. 中国医学科学杂志（英文）, 2024,39(2):102-110.

Li Rong-Rong,Chen Wei,Xiao Xin-Hua,et al.Efficacy of Raw Corn Starch in Insulinoma-Related Hypoglycemia: A Promising Supportive Therapy[J].Chinese Medical Sciences Journal,2024,39(02):102-110.
生玉米淀粉改善胰岛素瘤相关低血糖的疗效：一种有前景的支持治疗[J]. 中国医学科学杂志（英文）, 2024,39(2):102-110. DOI： 10.24920/004329.

Li Rong-Rong,Chen Wei,Xiao Xin-Hua,et al.Efficacy of Raw Corn Starch in Insulinoma-Related Hypoglycemia: A Promising Supportive Therapy[J].Chinese Medical Sciences Journal,2024,39(02):102-110. DOI： 10.24920/004329.

摘要

Abstract

Objective

To investigate the efficacy of raw corn starch (RCS) in clinical management of insulinoma-induced hypoglycemia.

Methods

We retrospectively collected clinical data of insulinoma patients who received RCS-supplemented diet preoperatively

and analyzed the therapeutic effects of the RCS intervention on blood glucose control

weight change

and its adverse events.

Results

The study population consisted of 24 cases of insulinoma patients

7 males and 17 females

aged 46.08±14.15 years. Before RCS-supplemented diet

all patients had frequent hypoglycemic episodes (2.51±3.88 times/week)

concurrent with neuroglycopenia (in 83.3% of patients) and autonomic manifestations (in 75.0% of patients)

with the median fasting blood glucose (FBG) of 2.70 (interquartile range [IQR

]

: 2.50–2.90) mmol/L. The patients' weight increased by 0.38 (IQR: 0.05–0.65) kg per month

with 8 (33.3%) cases developing overweight and 7 (29.2%) cases developing obesity. All patients maintained the RCS-supplemented diet until they underwent tumor resection (23 cases) and transarterial chemoembolization for liver metastases (1 case). For 19 patients receiving RCS throughout the day

the median FBG within one week of nutritional management was 4.30 (IQR: 3.30–5.70) mmol/L

which was a significant increase compared to pre-nutritional level [2.25 (IQR: 1.60–2.90) mmol/L;

0.001

]

. Of them

10 patients receiving RCS throughout the day for over four weeks had sustained improvement in FBG compared to pre-treatment [3.20 (IQR: 2.60–3.95) mmol/L

. 2.15 (IQR: 1.83–2.33) mmol/L;

0.001). Five patients who received RCS only at night also had a significant increase in FBG within one week of nutritional management [3.50 (IQR: 2.50–3.65) mmol/L

. 2.20 (IQR:1.80–2.60) mmol/L;

0.001

]

but only one patient who continued to receive RCS for over four weeks did not have a significant improvement in FBG. No improvement in weight gain was observed upon RCS supplementation. Mild diarrhea (2 cases) and flatulence (1 case) occurred

and were relieved by reduction of RCS dose.

Conclusion

The RCS-supplemented diet is effective in controlling insulinoma-induced hypoglycemia.

关键词

Keywords

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