尿液髓过氧化物酶肌酐比值作为诊断泌尿系感染的新标志物

柏明见; 冯璟; 梁国威

doi:10.24920/11814

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尿液髓过氧化物酶肌酐比值作为诊断泌尿系感染的新标志物

Chinese Medical Sciences Journal 2018年33卷第3期页码：152-159

研究论文 | Updated：2024-04-10

- 尿液髓过氧化物酶肌酐比值作为诊断泌尿系感染的新标志物
- Affiliations：
  
  航天中心医院检验科,北京 100049
- Author bio：
  
  * Tel: 86-10-88526300, Fax: 86-10-88526300, E-mail: liangguowei721@126.com
- Funds：
  
  Supported by Youth Innovation Fund of Aerospace Central Hospital(2015QN07)
- DOI：10.24920/11814
  中图分类号：
- 网络出版日期：2018-09-20，
  
  纸质出版日期：2018-09-20
- Accepted：
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柏明见, 冯璟, 梁国威. 尿液髓过氧化物酶肌酐比值作为诊断泌尿系感染的新标志物[J]. Chinese Medical Sciences Journal, 2018,33(3):152-159.

Bai Mingjian, Feng Jing, Liang Guowei. Urinary Myeloperoxidase to Creatinine Ratio as a New Marker for Diagnosis of Urinary Tract Infection[J]. Chinese medical sciences journal, 2018, 33(3): 152-159.
柏明见, 冯璟, 梁国威. 尿液髓过氧化物酶肌酐比值作为诊断泌尿系感染的新标志物[J]. Chinese Medical Sciences Journal, 2018,33(3):152-159. DOI： 10.24920/11814.

Bai Mingjian, Feng Jing, Liang Guowei. Urinary Myeloperoxidase to Creatinine Ratio as a New Marker for Diagnosis of Urinary Tract Infection[J]. Chinese medical sciences journal, 2018, 33(3): 152-159. DOI： 10.24920/11814.

摘要

目的

探讨尿髓过氧化物酶与肌酐比值（MCR）是否可作为泌尿系感染（UTI）诊断的指标。

方法

将疑似UTI的患者根据尿培养结果分为培养阳性组和培养阴性组。并对两组患者尿液MCR、白细胞（WBC）和细菌进行检测和比较。

结果

253例患者中有157例尿培养阳性

96例培养阴性。尿MCR、WBC和细菌分别以2为基数取对数。尿液培养阳性组和阴性组间log2MCR、log2WBC（定量）、log2bacteria、WBC（半定量）水平分别为（8.6±2.5比5.4±1.5

t=-12.453

P=0.001）、（8.0±2.5比5.2±1.8

t=-10.332

P=0.001）、（11.4±2.5比8.2±2.8

t=-9.297

P=0.001）、[2（1

3）比1（0.5

1）

Z=-7.580

P=0.001]

差异均有统计学意义。在尿培养阳性组中

革兰阳性菌组与阴性菌组的log2MCR水平分别为7.2±2.5 和9.0±2.4

t=4.016

P=0.001

差异有统计学意义。log2MCR与log2WBC（定量）、log2bacteria、WBC（半定量）相关性（Pearson）分别为0.708（P=0.001）、0.381（P=0.001）、0.606 （P=0.001）。

结论

MCR与WBC计数呈正相关

可作为诊断UTI新的标志物。MCR甚至可以用于初步推断UTI的细菌类型。

Abstract

Objective

To determine whether urinary myeloperoxidase to creatinine ratio (MCR) can serve as a marker for diagnosis of urinary tract infection (UTI).

Methods

Patients suspected of UTI were consecutively enrolled and further divided into the culture positive and the sterile groups according to urine culture results. Subsequently

MCR

white blood cell (WBC) and bacteria in the urinary samples from patients were detected and compared between the two groups.

Results

Finally

253 patients were enrolled including 157 urine culture positive patients and 96 urine culture negative patients (sterile group). After logarithmic transformation in 2 as the base

the MCR

WBC

and bacteria were separately presented as log

MCR

log

WBC

(quantitative)

and log

bacteria

. The values of log

MCR

(8.6±2.5

. 5.4±1.5

=-12.453

=0.001)

log

WBC

(quantitative) (8.0±2.5

. 5.2±1.8

=-10.332

=0.001)

log

bacteria

(11.4±2.5

. 8.2±2.8

=-9.297

=0.001) and WBC (semi-quantitative) [2 (interquartile range 1

. 1 (interquartile range 0.5

=-7.580

=0.001] showed significant difference between the urine culture positive group and the sterile group. Among the urine culture positive group

the values of log

MCR

of the gram positive and gram negative subgroups were 7.2±2.5 and 9.0±2.4 (

=4.016

=0.001)

respectively. The correlation between log

MCR

and log

WBC

(quantitative)

log

bacteria

WBC (semi-quantitative) was 0.708 (

Pearson

correlation

=0.001)

0.381 (

Pearson

correlation

=0.001)

and 0.606 (

Spearman

correlation

=0.001)

respectively.

Conclusions

MCR is positively correlated with WBC counts and could be served as a promising biomarker for diagnosis of UTI. MCR could be even used for initial inference of infectious bacteria types of UTI.

关键词

Keywords

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