“In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.”
“In the digital economy era, China's medical AI applications are advancing rapidly. The China National Health Development Research Center has established a value assessment framework for AI medical technologies, formulated the country's first technical guideline for clinical evaluation, and validated their practicality through scenario-based pilot studies. The paper also proposes introducing a "regulatory sandbox" model to test technical compliance in controlled environments, thereby balancing innovation incentives with risk governance.”
“In the era of big data, biomedical data is growing rapidly, presenting challenges in data management. This article summarizes China's policies, data collection, platform construction, and applications in biomedical data, aiming to identify key issues and needs, enhance platform construction capacity, unleash data value, and leverage China's vast data advantages.”
“In the medical and health sectors, data space is emerging as an innovative model for data management and sharing. This study introduces its research progress in the field of data space, which provides solutions to solve the challenges of limited computing resources, data integration complexities, and the need for optimized algorithms. Technological innovation, sound regulations, and optimized management will help the development of the medical and health data space, enabling the secure and efficient utilization of data.”
“In the field of viral infectious diseases, this review explores the multifaceted nature of the diseases and summarizes relevant data across multiple levels. It traces the historical evolution of data collection, evaluates current limitations, and proposes strategies to surmount challenges, focusing on advanced computational techniques, AI-driven models, and enhanced data integration practices.”
“Biomedical big data, with its massive scale, multi-dimensionality, and heterogeneity, offers novel perspectives for disease research, elucidates biological principles, and simultaneously prompts changes in related research methodologies. Biomedical ontology, as a shared formal conceptual system, not only offers standardized terms for multi-source biomedical data but also provides a solid data foundation and framework for biomedical research. In this review, we summarize enrichment analysis and deep learning for biomedical ontology based on its structure and semantic annotation properties, highlighting how technological advancements are enabling the more comprehensive use of ontology information. Enrichment analysis represents an important application of ontology to elucidate the potential biological significance for a particular molecular list. Deep learning, on the other hand, represents an increasingly powerful analytical tool that can be more widely combined with ontology for analysis and prediction. With the continuous evolution of big data technologies, the integration of these technologies with biomedical ontologies is opening up exciting new possibilities for advancing biomedical research.”
“In the field of traditional Chinese medicine (TCM) education, researchers have introduced Formula-S, a situated visualization method for TCM formula learning in augmented reality (AR). This interactive AR tool, featuring three modes (3D, Web, and Table), provides solutions to enhance TCM formula learning for beginners, offering more efficient and accurate searching capabilities compared to traditional and web-based methods.”
“In the field of single-cell RNA sequencing, researchers have developed the PAN-blood single-cell Data Annotator (scPANDA) system, which leverages a comprehensive 10-million-cell atlas to provide precise cell type annotation. This system exemplifies effective reference mapping with a large-scale atlas, enhancing the accuracy and reliability of blood cell type identification.”
李昶啸, 黄璨, 陈东升
2025, 40(1): 68-87. DOI: 10.24920/004472
Abstract:目的单细胞测序的最新进展彻底改变了细胞异质性的研究,特别是在血液系统中尤为明显。由于免疫细胞的复杂性,准确注释细胞类型仍然具有极大挑战。为了应对这一挑战,我们开发了泛血液单细胞数据注释工具(PAN-blood single-cell Data Annotator, scPANDA),利用一个全面的1000万细胞图谱来实现细胞类型的精确注释。方法我们搜集了来自16项研究的单细胞转录组数据,进行了严格的质量控制、预处理和整合以确保质量。scPANDA采用三层推断方法,逐步将细胞类型从宽泛的分类细化到特定细胞簇。在整个分析过程中,采用迭代聚类和整合来保持细胞类型的纯度。我们进一步在三个外部数据集中评估了scPANDA的性能。结果该图谱的分层结构由16个大类、54个小类、4460个低级簇(pd_cc_cl_tfs)和611个高级簇(pmid_cts)构组。该工具在注释不同的免疫数据集、分析癌症中免疫-肿瘤共存簇以及鉴定不同物种的保守细胞簇方面的稳健表现体现了其有效性。结论scPANDA通过大规模细胞图谱展示了高效的参考映射方法,提升了血液细胞类型识别的准确性和可靠性。