Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy

Li Yan-feng; Ge Fang-fang; Zhang Yong; You Hui; Zhang Zhen-xin

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Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy

中国医学科学杂志（英文版） 2015年30卷第3期页码：170-173

Orginal Article | Updated：2024-04-10

- Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy
- Affiliations：
  
  1Department of Neurology,
  2Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2015-06-20，
  
  纸质出版日期：2015-06
- Accepted：
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Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy[J]. 中国医学科学杂志（英文版）, 2015,30(3):170-173.

Li Yan-feng, Ge Fang-fang, Zhang Yong, et al. Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy[J]. Chinese medical sciences journal, 2015, 30(3): 170-173.
Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy[J]. 中国医学科学杂志（英文版）, 2015,30(3):170-173. DOI：

Li Yan-feng, Ge Fang-fang, Zhang Yong, et al. Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy[J]. Chinese medical sciences journal, 2015, 30(3): 170-173. DOI：

摘要

Abstract

Objective

To study the changes of biomarkers in cerebrospinal fluid (CSF) in cerebral amyloid angiopathy (CAA) dementia and Alzheimer

’

s disease.

Methods

Levels of amyloid protein β (Aβ

Aβ

) and phosphorylated Tau-protein (P-tau) in CSF and ratio of Aβ

/Aβ

were tested in 5 cases with CAA dementia and 20 cases with Alzheimer’s disease collected at Peking Union Medical College Hospital from December 2001 to March 2011.

Results

The levels of Aβ

Aβ

and P-tau in CSF and ratio of Aβ

/Aβ

were (660.4±265.2) ng/L

(7111.0±1033.4) ng/L

(71.8±51.5) ng/L

and 0.077±0.033

respectively in CAA dementia and (663.6±365.6) ng/L

(5115.0±2931.1) ng/L

(47.7±38.8) ng/L

and 0.192±0.140

respectively in Alzheimer’s disease patients. There were no statistically significant differences between CAA dementia and Alzheimer’s disease in terms of these CSF biomarkers (all

0.05).

Conclusion

Measurements of CSF biomarkers may not be helpful in differential diagnosis of CAA and Alzheimer’s disease.

关键词

Keywords

references

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