Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Yang Bo; Wang Jiansheng

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Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

中国医学科学杂志（英文版） 2017年32卷第1期页码：13-21

Orginal Article | Updated：2024-04-10

- Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials
- Affiliations：
  
  Department of Urology, Xixi Hospital of Hangzhou, Hangzhou 310023, China
- Author bio：
  
  *Corresponding author Tel: 86-571-86481510; Fax: 86-571-86481510; E-mail: xxyyyangbo@aliyun.com
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2017-04-11，
  
  纸质出版日期：2017-04
- Accepted：
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Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials[J]. 中国医学科学杂志（英文版）, 2017,32(1):13-21.

Yang Bo, Wang Jiansheng. Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials[J]. Chinese medical sciences journal, 2017, 32(1): 13-21.
Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials[J]. 中国医学科学杂志（英文版）, 2017,32(1):13-21. DOI：

Yang Bo, Wang Jiansheng. Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials[J]. Chinese medical sciences journal, 2017, 32(1): 13-21. DOI：

摘要

Abstract

Objective

To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy

specifically cancer-related fatigue (CRF) and quality of life (QoL).

Methods

Systematic searches for randomized clinical trials (RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE

PubMed and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Standardized mean differences (SMD) and its 95% confidence interval (

) were calculated.

Results

In all

10 RCTs involving 841 prostate cancer patients (448 of whom exercised and 393 did not) were included in this study. With respect to CRF

there was good consistency among different studies

and it was remarkably reduced in the exercise group (SMD=-0.32

95%

: -0.45 to -0.18

0.00001

=784). In regards to QoL

there was also good consistency among different studies

and it was also improved significantly in the exercise group (SMD=0.21

95%

: 0.08 to 0.34

=0.002

=841).

Conclusion

Exercise both reduced CRF and improved QoL in prostate cancer patients receiving androgen deprivation therapy.

关键词

Keywords

references

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