Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

Yu Yong-qiang; Yang Huai-an; Xiao Ming; Wang Jing-wei; Huang Dong-yan; Bhambhani Yagesh; Sonnenberg Lyn; Clark Brenda; Jin Yuan-zhe; Fu Wei-neng; Zhang Jie; Yu Qian; Liang Xue-ting; Zhang Ming

Your Location：

Home >

Browse articles >

Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

中国医学科学杂志（英文版） 2015年30卷第3期页码：179-188

Orginal Article | Updated：2024-04-10

- Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss
- Affiliations：
  
  1Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, Edmonton, AB T6G 2B7, Canada
  12Department of Surgery-Otolaryngology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
  4Department of Obstetrics and Gynecology, Edmonton, AB T6G 2B7, Canada
  2Department of Otolaryngology, The First Affiliated Hospital, Shenyang 110001, China
  8Department of Medical Genetics, Shenyang 110001, China
  9Department of Biochemistry, China Medical University, Shenyang 110001, China
  11Department of Medical Imageology, China Medical University, Shenyang 110001, China
  3Department of Surgery, The People’s Hospital of Liaoning Province, Shenyang 110016, China;
  5Department of Otolaryngology-Head & Neck Surgery, PLA General Hospital, Beijing 100853, China;
  6Department of Developmental Pediatrics
  13Department of Audiology, Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada
  7Department of Cardiology, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China
  10 School of Business, University of Alberta, Edmonton, AB T6G 2G4, Canada
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2015-06-20，
  
  纸质出版日期：2015-06
- Accepted：
Scan QR Code
Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss[J]. 中国医学科学杂志（英文版）, 2015,30(3):179-188.

Yu Yong-qiang, Yang Huai-an, Xiao Ming, et al. Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss[J]. Chinese medical sciences journal, 2015, 30(3): 179-188.
Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss[J]. 中国医学科学杂志（英文版）, 2015,30(3):179-188. DOI：

Yu Yong-qiang, Yang Huai-an, Xiao Ming, et al. Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss[J]. Chinese medical sciences journal, 2015, 30(3): 179-188. DOI：

摘要

Abstract

In this article

the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL)

i.e. hearing aid and cochlear implant

are effective for some cases

but not without limitations. For example

they provide little benefit for patients of profound SNHL or neural hearing loss

especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field

which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage

it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.

关键词

Keywords

references

Yang M , Tan H , Yang Q , et al. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell Stress Chaperones 2006 ; 11 : 233 - 9 .

Konings A , Van Laer L , Michel S , et al. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. Eur J Hum Genet 2008 ; 17 : 329 - 35 .

Jackler RK , Luxford WM , House WF. Congenital malforma- tions of the inner ear: a classification based on embryo- genesis. Laryngoscope 1987 ; 97 : 2 - 14 .

Chen J , Streit A. Induction of the inner ear: stepwise specification of otic fate from multipotent progenitors. Hear Res 2013 ; 297 : 3 - 12 .

Bilgin H , Kasemsuwan L , Schachern PA , et al. Temporal bone study of Down's syndrome. Arch Otolaryngol Head Neck Surg 1996 ; 122 : 271 - 5 .

Shah RK , Blevins NH , Karmody CS. Mid-frequency sensorineural hearing loss: aetiology and prognosis. J Laryngol Otol 2005 ; 119 : 529 - 33 .

Bayazit YA , Yilmaz M. An overview of hereditary hearing loss. ORL J Otorhinolaryngol Relat Spec 2006 ; 68 : 57 - 63 .

Reddy MV , Sathyanarayana VV , Sailakshmi V , et al. An epidemiological study on children with syndromic hearing loss. Indian J Otolaryngol Head Neck Surg 2004 ; 56 : 208 - 12 .

9.Smith RJH , Van Camp G. Nonsyndromic hearing loss and deafness , DFNB1. In Pagon RA , Adam MP , Ardinger HH , et al , eds. GeneReviews [Internet]. Seattle: University of Washington , Seattle. 2014 .

Petersen MB , Willems PJ. Non-syndromic, autosomal- recessive deafness. Clin Genet 2006 ; 69 : 371 - 92 .

Zelante L , Gasparini P , Estivill X , et al. Connexin26 mutations associated with the most common form of non-syndromic neurosensory autosomal recessive deafness (DFNB1) in Mediterraneans. Hum Mol Genet 1997 ; 6 : 1605 - 9 .

Estivill X , Fortina P , Surrey S , et al. Connexin-26 mutations in sporadic and inherited sensorineural dea- fness. Lancet 1998 ; 351 : 394 - 8 .

Kelley PM , Harris DJ , Comer BC , et al. Novel mutations in the connexin 26 gene (GJB2) that cause autosomal recessive (DFNB1) hearing loss. Am J Hum Genet 1998 ; 62 : 792 - 9 .

Friedman TB , Schultz JM , Ahmed ZM , et al. Usher syndrome: hearing loss with vision loss. Adv Otorhino- laryngol 2011 ; 70 : 56 - 65 .

Blanco-Kelly F , Jaijo T , Aller E , et al. Clinical aspects of Usher syndrome and the USH2A gene in a cohort of 433 patients. JAMA Ophthalmol 2015 ; 133 : 157 - 64 .

Yazdanpanahi N , Tabatabaiefar MA , Bagheri N , et al. The role and spectrum of SLC26A4 mutations in Iranian patients with autosomal recessive hereditary deafness. Int J Audiol 2015 ; 54 : 124 - 30 .

Yang WP , Levesque PC , Little WA , et al. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci U S A 1997 ; 94 : 4017 - 21 .

Al-Aama JY , Al-Ghamdi S , Bdier AY , et al. De novo mutation in the KCNQ1 gene causal to Jervell and Lange-Nielsen syndrome. Clin Genet 2014 ; 86 : 492 - 5 .

Scholtz AW , Fish JH 3rd, Kammen-Jolly K, et al. Goldendar's syndrome: congenital hearing deficit of conductive or sensorineural origin? Temporal bone histopathologic study. Otol Neurotol 2001 ; 22 : 501 - 5 .

Chafai Elalaoui S , Cherkaoui Jaouad I , Rifai L , et al. Autosomal dominant microtia. Eur J Med Genet 2010 ; 53 : 100 - 3 .

Robertson NG , Lu L , Heller S , et al. Mutations in a novel cochlear gene cause DNFA9, a human nonsyndromic deafness with vestibular dysfunction. Nat Genet 1998 ; 20 : 299 - 303 .

Otręba M , Miliński M , Buszman E , et al. Hereditary hypomelanocytoses: the role of PAX3, SOX10, MITF, SNAI2, KIT, EDN3 and EDNRB genes. Postepy Hig Med Dosw (Online) 2013 ; 67 : 1109 - 18 .

Vervoort VS , Smith RJ , O’Brien J, et al. Genomic rearrangements of EYA1 account for a large fraction of families with BOR syndrome. Eur J Hum Genet 2002 ; 10 : 757 - 66 .

Ruf RG , Xu PX , Silvius D , et al. SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1- DNA complexes. Proc Natl Acad Sci U S A 2004 ; 101 : 8090 - 5 .

Hoskins BE , Cramer CH , Silvius D , et al. Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. Am J Hum Genet 2007 ; 80 : 800 - 4 .

Acke FR , Dhooge IJ , Malfait F , et al. Hearing impairment in Stickler syndrome: a systematic review. Orphanet J Rare Dis 2012 ; 7 : 84 .

Sanson M , Marineau C , Desmaze C , et al. Germline deletion in a neurofibromatosis type 2 kindred inactivates the NF2 gene and a candidate meningioma locus. Hum Mol Genet 1993 ; 2 : 1215 - 20 .

Pelletier LP , Tanguay RB. X-linked recessive inheritance of sensorineural hearing loss expressed during adolescence. Am J Hum Genet 1975 ; 27 : 609 - 13 .

Dobyns WB , Filauro A , Tomson BN , et al. Inheritance of most X-linked traits is not dominant or recessive, just X-linked. Am J Med Genet A 2004 ; 129A : 136 - 43 .

Liu X , Han D , Li J , et al. Loss-of-function mutations in the PRPS1 gene cause a type of nonsyndromic X-linked sensorineural deafness, DFN2. Am J Hum Genet 2010 ; 86 : 65 - 71 .

de Kok YJ , van der Maarel SM , Bitner-Glindzicz M , et al . Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4. Science 1995 ; 267 : 685 - 8 .

Lalwani AK1 , Brister JR , Fex J , et al . A new nonsyndromic X-linked sensorineural hearing impairment linked to Xp21.2. Am J Hum Genet 1994 ; 55 : 685 - 94 .

del Castillo I , Villamar M , Sarduy M , et al . A novel locus for non-syndromic sensorineural deafness (DFN6) maps to chromosome Xp22. Hum Mol Genet 1996 ; 5 : 1383 - 7 .

Wang QJ , Li QZ , Rao SQ , et al. AUNX1, a novel locus responsible for X linked recessive auditory and peripheral neuropathy, maps to Xq23-27.3. J Med Genet 2006 ; 43 : e33 .

Kruegel J , Rubel D , Gross O. Alport syndrome--insights from basic and clinical research. Nat Rev Nephrol 2013 ; 9 : 170 - 8 .

36.Tranebjærg L. Deafness-dystonia-optic neuronopathy syndrome. In Pagon RA , Adam MP , Ardinger HH , et al , eds. GeneReviews [Internet]. Seattle: University of Washington,Seattle. 2013 .

Gutiérrez Cortés N , Pertuiset C , Dumon E , et al. Novel mitochondrial DNA mutations responsible for maternally inherited nonsyndromic hearing loss. Hum Mutat 2012 ; 33 : 681 - 9 .

Fischel-Ghodsian N. Mitochondrial mutations and hearing loss: paradigm for mitochondrial genetics. Am J Hum Genet 1998 ; 62 : 15 - 9 .

Raynor LA , Pankow JS , Miller MB , et al. Familial aggregation of age-related hearing loss in an epidemiological study of older adults. Am J Audiol 2009 ; 18 : 114 - 8 .

Gates GA , Couropmitree NN , Myers RH. Genetic associations in age-related hearing thresholds. Arch Otolaryngol Head Neck Surg 1999 ; 125 : 654 - 9 .

Rodriguez-Paris J , Ballay C , Inserra M , et al. Genetic analysis of presbycusis by arrayed primer extension. Ann Clin Lab Sci 2008 ; 38 : 352 - 60 .

Spoendlin H. Primary structural changes in the organ of Corti after acoustic overstimulation. Acta Otolaryngol 1971 ; 71 : 166 - 76 .

Hunter-Duvar IM , Bredberg G. Effects of intense auditory stimulation: hearing losses and inner ear changes in the chinchilla. J Acoust Soc Am 1974 ; 55 : 795 - 801 .

Hunter-Duvar IM , Elliott DN. Effects of intense auditory stimulation: hearing losses and inner ear changes in the squirrel monkey. J Acoust Soc Am 1972 ; 52 : 1181 - 92 .

Hunter-Duvar IM , Elliott DN. Effects of intense auditory stimulation: hearing losses and inner ear changes in the squirrel monkey. II. J Acoust Soc Am 1973 ; 54 : 1179 - 83 .

Hamernik RP , Henderson D. Impulse noise trauma. A study of histological susceptibility. Arch Otolaryngol 1974 ; 99 : 118 - 21 .

Hawkins JE Jr , Johnsson LG , Stebbins WC , et al. Hearing loss and cochlear pathology in monkeys after noise exposure. Acta Otolaryngol 1976 ; 81 : 337 - 43 .

Mulroy MJ , Henry WR , McNeil PL. Noise-induced transient microlesions in the cell membranes of auditory hair cells. Hear Res 1998 ; 115 : 93 - 100 .

Lim DJ , Melnick W. Acoustic damage of the cochlea. A scanning and transmission electron microscopic obser- vation. Arch Otolaryngol 1971 ; 94 : 294 - 305 .

Yamane H , Nakai Y , Takayama M , et al. Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma. Eur Arch Otorhinolaryngol 1995 ; 252 : 504 - 8 .

Ohlemiller KK , McFadden SL, Ding DL, et al. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol 1999 ; 4 : 237 - 46 .

Ohlemiller KK , Wright JS , Dugan LL. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 1999 ; 4 : 229 - 36 .

Ohlemiller KK , McFadden SL, Ding DL, et al. Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol 2000 ; 1 : 243 - 54 .

McFadden SL , Ding DL , Ohlemiller KK , et al . The role of superoxide dismutase in age-related and noise-induced hearing loss: clues from Sod1 knockout mice. In: Willot JF, ed. Handbook of mouse auditory research: from behavior to molecular biology . New York : CRC Press . 2001 . p. 489 - 504 .

Halliwell B , Gutteridge JMC. Free Radicals in Biology and Medicine, third ed. London : Oxford University Press . 1888 .

Patuzzi RB , Yates GK , Johnstone BM. The origin of the low-frequency microphonic in the first cochlear turn of guinea-pig. Hear Res 1989 ; 39 : 177 - 88 .

Hawkins JE Jr. The role of vasoconstriction in noise- induced hearing loss. Ann Otol Rhinol Laryngol 1971 ; 80 : 903 - 13 .

Hawkins JE Jr , Johnsson LG , Preston RE. Cochlear micro- vasculature in normal and damaged ears. Laryngoscope 1972 ; 82 : 1091 - 104 .

Lipscomb DM , Roettger RL. Capillary constriction in cochlear and vestibular tissues during intense noise stimulation. Laryngoscope 1973 ; 83 : 259 - 63 .

Axelsson A , Dengerink H. The effects of noise on histological measures of the cochlear vasculature and red blood cells: a review. Hear Res 1987 ; 31 : 183 - 91 .

Axelsson , A. , Vertes , D. Histological findings in cochlear vessels after noise. In: Hamernik R, Anderson D, Salvi R, eds. New perspectives in noise-induced hearing loss . New York : Raven Press . 1981 . p. 49 - 68 .

Duvall AJ 3rd , Robinson KS . Local vs systemic effects of acoustic trauma on cochlear structure and transport. Arch Otolaryngol Head Neck Surg 1987 ; 113 : 1066 - 71 .

Scheibe F , Haupt H , Ludwig C. Intensity-related changes in cochlear blood flow in the guinea pig during and following acoustic exposure. Eur Arch Otorhinolaryngol 1993 ; 250 : 281 - 5 .

Haupt H , Scheibe F. Preventive magnesium supplement protects the inner ear against noise-induced impairment of blood flow and oxygenation in the guinea pig. Magnes Res 2002 ; 15 : 17 - 25 .

Henderson D , Bielefeld EC , Harris KC , et al. The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006 ; 27 : 1 - 19 .

Erway LC , Shiau YW , Davis RR , et al. Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hear Res 1996 ; 93 : 181 - 7 .

Johnson KR , Erway LC , Cook SA , et al. A major gene affecting age-related hearing loss in C57BL/6J mice. Hear Res 1997 ; 114 : 83 - 92 .

Noben-Trauth K , Zheng QY , Johnson KR. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 2003 ; 35 : 21 - 3 .

Holme RH , Steel KP. Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation. J Assoc Res Otolaryngol 2004 ; 5 : 66 - 79 .

Konings A , Van Laer L , Pawelczyk M , et al. Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations. Hum Mol Genet 2007 ; 16 : 1872 - 83 .

Van Laer L , Carlsson PI , Ottschytsch N , et al. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. Hum Mutat 2006 ; 27 : 786 - 95 .

Sliwinska-Kowalska M , Pawelczyk M. Contribution of genetic factors to noise-induced hearing loss: a human studies review. Mutat Res 2013 ; 752 : 61 - 5 .

Kubisch C , Schroeder BC , Friedrich T , et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 1999 ; 96 : 437 - 46 .

Schulze-Bahr E , Wang Q , Wedekind H , et al. KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Nat Genet 1997 ; 17 : 267 - 8 .

Lim HH , Jenkins OH , Myers MW. Detection of HSP 72 synthesis after acoustic overstimulation in rat cochlea. Hear Res 1993 ; 69 : 146 - 50 .

Samson J , Sheeladevi R , Ravindran R , et al. Stress response in rat brain after different durations of noise exposure. Neurosci Res 2007 ; 57 : 143 - 7 .

Konings A , Van Laer L , Van Camp G. Genetic studies on noise-induced hearing loss: a review. Ear Hear 2009 ; 30 : 151 - 9 .

Govaerts PJ , De Beukelaer C , Daemers K , et al. Outcome of cochlear implantation at different ages from 0 to 6 years. Otol Nuerotol 2002 ; 23 : 885 - 90 .

Mrena R , Ylikoski J , Kiukaanniemi H , et al. The effect of improved hearing protection regulations in the prevention of military noise-induced hearing loss. Acta Otolaryngol 2008 ; 128 : 997 - 1003 .

Attias J , Sapir S , Bresloff I , et al. Reduction in noise- induced temporary threshold shift in humans following oral magnesium intake. Clin Otolaryngol Allied Sci 2004 ; 29 : 635 - 41 .

Quaranta A , Scaringi A , Bartoli R , et al. The effects of ‘supra-physiological’ vitamin B12 administration on temporary threshold shift. Int J Audiol 2004 ; 43 : 162 - 5 .

Suckfuell M , Canis M , Strieth S , et al. Intra-tympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study. Acta Otolaryngol 2007 ; 127 : 938 - 42 .

Psillas G , Pavlidis P , Karvelis I , et al. Potential efficacy of early treatment of acute acoustic trauma with steroids and piracetam after gunshot noise. Eur Arch Otorhinolaryngol 2008 ; 265 : 1465 - 9 .

Wang J , Van De Water TR, Bonny C, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 2003 ; 23 : 8596 - 607 .

Wang J , Ruel J , Ladrech S , et al. Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol 2007 ; 71 : 654 - 66 .

Shim HJ , Kang HH , Ahn JH , et al. Retinoic acid applied after noise exposure can recover the noise-induced hearing loss in mice. Acta Otolaryngol 2009 ; 129 : 233 - 8 .

Ahn JH , Kang HH , Kim YJ , et al. Anti-apoptotic role of retinoic acid in the inner ear of noise exposed mice. Biochem Biophys Res Commun 2005 ; 335 : 485 - 90 .

Puel JL , Ruel J , Gervais d’Aldin C, et al. Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. Neuroreport 1998 ; 9 : 2109 - 14 .

Ohinata Y , Miller JM , Schacht J. Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Res 2003 ; 966 : 265 - 73 .

Hamernik RP , Qiu W , Davis B. The effectiveness of N-acetyl-L-cysteine (L-NAC) in the prevention of severe noise-induced hearing loss. Hear Res 2008 ; 239 : 99 - 106 .

Minami SB , Yamashita D , Schacht J , et al. Calcineurin activation contributes to noise-induced hearing loss. J Neurosci Res 2004 ; 78 : 383 - 92 .

Uemaetomari I , Tabuchi K , Nakamagoe M , et al. L-type voltage-gated calcium channel is involved in the pathogenesis of acoustic injury in the cochlea. Tohoku J Exp Med 2009 ; 218 : 41 - 7 .

Shen H , Zhang B , Shin JH , et al. Prophylactic and therapeutic functions of T-type calcium blockers against noisei-nduced hearing loss. Hear Res 2007 ; 226 : 52 - 60 .

Shoji F , Yamasoba T , Magal E , et al. Glial cell line-derived neurotrophic factor has a dose dependent influence on noise-induced hearing loss in the guinea pig cochlea. Hear Res 2000 ; 142 : 41 - 55 .

Shoji F , Miller AL , Mitchell A , et al. Differential protective effects of neurotrophins in the attenuation of noise- induced hair cell loss. Hear Res 2000 ; 146 : 134 - 42 .

Yamasoba T , Altschuler RA , Raphael Y , et al. Absence of hair cell protection by exogenous FGF-1 and FGF-2 deli- vered to guinea pig cochlea in vivo . Noise Health 2001 ; 3 : 65 - 78 .

Shibata SB , Osumi Y , Yagi M , et al. Administration of amitriptyline attenuates noise-induced hearing loss via glial cell line-derived neurotrophic factor (GDNF) induction. Brain Res 2007 ; 1144 : 74 - 81 .

Yamasoba T , Harris C , Shoji F , et al. Influence of intense sound exposure on glutathione synthesis in the cochlea. Brain Res 1998 ; 804 : 72 - 8 .

Ohinata Y , Yamasoba T , Schacht J , et al. Glutathione limits noise-induced hearing loss. Hear Res 2000 ; 146 : 28 - 34 .

Pourbakht A , Yamasoba T. Ebselen attenuates cochlear damage caused by acoustic trauma. Hear Res 2003 ; 181 : 100 - 8 .

McFadden SL , Woo JM , Michalak N , et al . Dietary vitamin C supplementation reduces noise induced hearing loss in guinea pigs. Hear Res 2005 ; 202 : 200 - 8 .

Heinrich UR , Fischer I , Brieger J , et al. Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear. Laryngoscope 2008 ; 118 : 837 - 42 .

Fetoni AR , Piacentini R , Fiorita A , et al. Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Res 2009 ; 1257 : 108 - 16 .

Seidman M , Babu S , Tang W , et al. Effects of resveratrol on acoustic trauma. Otolaryngol Head Neck Surg 2003 ; 129 : 463 - 70 .

Campbell KC , Meech RP , Klemens JJ , et al. Prevention of noise- and drug-induced hearing loss with D-methionine. Hear Res 2007 ; 226 : 92 - 103 .

Kramer S , Dreisbach L , Lockwood J , et al. Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music. J Am Acad Audiol 2006 ; 17 : 265 - 78 .

Wise AK , Hume CR , Flynn BO , et al. Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea. Mol Ther 2010 ; 18 : 1111 - 22 .

Fukui H , Raphael Y. Gene therapy for the inner ear. Hear Res 2013 ; 297 : 99 - 105 .

Bermingham NA , Hassan BA , Price SD , et al. Math1: an essential gene for the generation of inner ear hair cells. Science 1999 ; 284 : 1837 - 41 .

Chen X , Frisina RD , Bowers WJ , et al. HSV amplicon mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Mol Ther 2001 ; 3 : 958 - 63 .

Bowers WJ , Chen X , Guo H , et al. Neurotrophin-3 ransduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol Ther 2002 ; 6 : 12 - 8 .

Kawamoto K , Yagi M , Stöver T , et al. Hearing and hair cells are protected by adenoviral gene therapy with TGF-beta1 and GDNF. Mol Ther 2003 ; 7 : 484 - 92 .

Shibata SB , Cortez SR , Beyer LA , et al. Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae. Exp Neurol 2010 ; 223 : 464 - 72 .

Kelly MC , Chang Q , Pan A , et al. Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo. J Neurosci 2012 ; 32 : 6699 - 710 .

Yang SM , Chen W , Guo WW , et al. Regeneration of stereocilia of hair cells by forced Atoh1 expression in the adult mammalian cochlea. PLoS One 2012 ; 7 : e46355 .

Akil O , Seal RP , Burke K , et al. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron 2012 ; 75 : 283 - 93 .

Zhang PZ , He Y , Jiang XW , et al. Stem cell transplantation via the cochlear lateral wall for replacement of dege- nerated spiral ganglion neurons. Hear Res 2013 ; 298 : 1 - 9 .

Choi MY , Yeo SW , Park KH. Hearing restoration in a deaf animal model with intravenous transplantation of mesenchymal stem cells derived from human umbilical cord blood. Biochem Biophys Res Commun 2012 ; 427 : 629 - 36 .

Zhang M , Assouline JG. Cilia containing 9 + 2 structures grown from immortalized cells. Cell Res 2007 ; 17 : 537 - 45 .

Sha SH , Schacht J. Salicylate attenuates gentamicin- induced ototoxicity. Lab Invest 1999 ; 79 : 807 - 13 .

Sha SH , Qiu JH , Schacht J. Aspirin to prevent gentamicin- induced hearing loss. N Engl J Med 2006 ; 354 : 1856 - 7 .

Caulfield T , Zarzeczny A , Toronto Stem Cell Working Group. Stem cell tourism and Canadian family physicians. Can Fam Physician 2012 ; 58 : 365 - 8 .

浏览量

1706

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据