Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis

Guo Chun-lan; Zhao* Ji-zhi; Zhang Jie; Dong Hai-tao

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Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis

中国医学科学杂志（英文版） 2015年30卷第4期页码：210-217

Orginal Article | Updated：2024-04-10

- Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis
- Affiliations：
  
  Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版日期：2015-08
- Accepted：
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Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis[J]. 中国医学科学杂志（英文版）, 2015,30(4):210-217.

Guo Chun-lan, Zhao* Ji-zhi, Zhang Jie, et al. Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis[J]. Chinese medical sciences journal, 2015, 30(4): 210-217.
Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis[J]. 中国医学科学杂志（英文版）, 2015,30(4):210-217. DOI：

Guo Chun-lan, Zhao* Ji-zhi, Zhang Jie, et al. Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis[J]. Chinese medical sciences journal, 2015, 30(4): 210-217. DOI：

摘要

Abstract

Objective

To assess the efficacy and safety of topical tacrolimus for erosive oral lichen planus (EOLP).

Methods

Literatures published up to December 2013 were searched from PubMed

Embase

CENTRAL

Chinese BioMedical Literature Database (CBM)

and System for Information on Grey Literature in Europe (SIGLE). All randomized controlled trials (RCTs) of topical tacrolimus for EOLP which compared with other interventions or a placebo were considered in this Meta-analysis. Two researchers collected data independently. The assessment of methodological quality was based on Cochrane Handbook and the materials were analyzed with the software Revman 5.2.5. The primary outcome measures were the symptoms (e.g. pain

discomfort) complained by patients. The secondary outcome measures included the improvement rate of clinical signs assessed by the investigators and the incidence of adverse effects (e.g. clinical candidiasis).

Results

A total of 9 RCTs involving 476 patients were finally included. The pooled odds ratio (

) of clinical improvement for topical tacrolimus

. topical corticosteroids was 1.19 [95% confidence interval (

): 0.64-2.22

: 44%]. Regarding to 0.1% tacrolimus and 0.03% tacrolimus

the pooled

were 1.87 (95 %

: 0.60-5.82) and 1.47 (95 %

: 0.14-16.04) respectively in subgroup analysis. No serious adverse events were reported in topical tacrolimus group.

Conclusions

There was no evidence to support that topical tacrolimus for EOLP was more effective and safer than topical corticosteroids in this Meta-analysis. Clinical assessment criteria should be established and accepted by clinicians and researchers before further RCTs are undertaken.

关键词

Keywords

references

Silverman S , Gorsky M , Lozada-Nur F. A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission and malignant association. Oral Surg Oral Med Oral Pathol 1985 ; 60 : 30 - 4 .

Lozada-Nur F , Miranda C. Oral lichen planus: epidemiology, clinical characteristics, and associated diseases. Semin Cutan Med Surg 1997 ; 16 : 273 - 7 .

Sugerman PB , Satterwhite K , Bigby M. Autocytotoxic T-cell clones in lichen planus. Br J Dematol 2000 ; 142 : 449 - 56 .

Kelly PA , Burckart GJ , Venkataramanan R. Tacrolimus: a new immunosuppressive agent. Am J Health Syst Pharm 1995 ; 52 : 1521 - 35 .

. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. 2011 [cited 2011 March 1]. Available from: http://www.cochrane-handbook. org http://www.cochrane-handbook. org

Chen C , Cheng SH , Di ZH , et al. Comparative study of 0.03% tacrolimus ointment and diprospan in the treatment of oral lichen planus (OLP). Prac Phar Clin Rem 2013 ; 10 : 924 - 5 .

Corrocher G , Di Lorenzo G , Martinelli N , et al. Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus. J Clin Periodontol 2008 ; 35 : 244 - 9 .

Laeijendecker R , Tank B , Dekker SK , et al. A comparison of treatment of oral lichen planus with topical tacrolimus and triamcinolone acetonide ointment. Acta Derm Venereol 2006 ; 86 : 227 - 9 .

Lv XJ. Clinical observation of therapeutic effect of tacrolimus ointment in the treatment of patients with erosive oral lichen planus. Chin Med Herald 2012 ; 9 : 141 - 2 .

Nie Z , Cai Z , Li ZH. Efficacy evaluation of tacrolimus on oral lichen planus. Chin J Leprosy Skin Dis 2010 ; 26 : 491 - 2 .

Redfar L , Wild RC , Suresh L. A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 ; 105 : 187 - 93 .

Sonthalia S , Singal A. Comparative efficacy of tacrolimus 0.1% ointment and clobetasol propionate 0.05% ointment in oral lichen planus: a randomized double-blind trial. Int J Dermatol 2012 ; 51 : 1371 - 8 .

Yang FH , Bai JW , Ren YZ , et al. The efficacy of tacrolimus 0.1% ointment in elderly patients with oral lichen planus. Chin J Geriatr Dent 2010 ; 8 : 145 - 7 .

Zuo WX , Li XY , Cai JY , et al. A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus. Shanghai J Stomatol 2013 ; 22 : 708 - 10 .

Fu H , Zhang Q , Zhou XW. Treatment of chronic erosive oral lichen planus with low concentrations of tacrolimus. J Oral Sci Res 2013 ; 29 : 1135 - 40 .

Arduino PG , Carbone M , Della Ferrera F , et al. Pimecrolimus vs . tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8-week randomized double-blind controlled study. J Eur Acad Dermatol Venereol 2013 ; 10 : 1 - 8 .

Jiang LY , Luo G , Yin C. The efficacy of 0.03% tacrolimus in the treatment of erosive oral lichen planus. J Dent Prev Treatment 2009 ; 17 : 476 - 8 .

Su SW , Cheng Z , Yan JJ. Efficacy evaluation of tacrolimus on erosive oral lichen planus. Strait Phar J 2010 ; 22 : 153 - 4 .

Thongprasom K , Carrozzo M , Furness S , et al. Interven- tions for treating oral lichen planus . Cochrane Database Syst Rev 2011 ; ( 7 ):CD001168.

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