Objective To evaluate the efficacy of minimally invasive perventricular device closure of ventricular septal defect (VSD).Methods Between September 2011 and February 2013

we collected 40 patients who underwent perventricular closure via a small lower sternal incision (minimally invasive group)

aged 15.5±3.5 years (12 months to 32 years) with a body weight of 24.2±7.5 kg (10.8-58.0 kg). The mean size of VSD was 5.6±0.5 mm (2-14 mm). Another 40 patients were included as the surgical group

receiving the conventional surgical repair of VSD. The device of the minimally invasive group was released under the guidance of transesophageal echocardiography. Success rate

cardiac indicators

and clinical outcomes of the 2 groups were compared.Results The patients in the surgical group and those in the minimally invasive group showed similar results in success rate (both 97.5%). The procedure time

intensive care unit stay

hospital stay

and postoperative recovery time in the minimally invasive group were significantly shorter than those in the surgical group (58±21 minutes versus 145±26 minutes

2±1 days versus 8±3 days

5±1 days versus 16±6 days

3±1 days versus 90±20 days

all P<0.05). The minimally invasive group had a higher incidence of conduction anomalies (17.5% versus 2.5%

P<0.05). In the follow-up period of 3-12 months

there was no new residual shunt

noticeable aortic regurgitation

significant arrhythmias

or device failure except for new complications in the surgical group.Conclusions The success rate of minimally invasive perventricular device closure of VSD under transesophageal echocardiography guidance is similar to that of conventional surgical repair

but the short-term outcomes of the minimally invasive approach is much better. Long-term follow-up is necessary to confirm the effectiveness of this technique.