False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis

Yun-chun Li; Fan Yang; Xiao-yun Ji; Zhong-jun Fang; Jun Liu; Yue Wang

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False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis

中国医学科学杂志（英文版） 2014年29卷第2期页码：103-106

Updated：2024-04-10

- False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis
- Affiliations：
  
  Department of Laboratory Center, Shanghai Guanghua Hospital of Integrative Medicine,Shanghai,China,200052
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2014-06-26，
  
  纸质出版日期：2014
- Accepted：
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Yun-chun Li, Fan Yang, Xiao-yun Ji, 等. False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis[J]. 中国医学科学杂志（英文版）, 2014,29(2):103-106.
Yun-chun Li, Fan Yang, Xiao-yun Ji, 等. False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis[J]. 中国医学科学杂志（英文版）, 2014,29(2):103-106. DOI：

DOI：

摘要

To investigate if immunological factors associated with rheumatoid arthritis (RA) affect the result of human immunodeficiency virus (HIV) screening by electrochemiluminescence immunoassay (ECLIA) and enzyme-linked immunosorbent assay (ELISA). 100 RA cases were enrolled from January 2012 to February 2013 into this study. HIV screening was conducted with ECLIA detecting both HIV-1 p24 antigen

HIV-1 and HIV-2 antibodies

with ELISA and colloidal gold method detecting HIV-1 and HIV-2 antibodies. The samples producing positive results were submitted to the Center for Disease Control for confirmation using Western blotting method. The antibody titers of rheumatoid factors (RF) including RF-IgG

RF-IgM

RF-IgA

and CCP-IgG were analyzed by ELISA. The HIV positive-rate determined by ECLIA was significantly higher than that by ELISA and colloidal gold method (<0.01). The false-positive rate of HIV screening was associated with antibody titers of RF-IgG

RF-IgM

RF-IgA

and CCP-IgG in RA (<0.01). Immunological factors

including RF and anti-CCP antibody

may influence the screening of HIV by ECLIA

producing false-positive result.

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