Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition

Yi Bao; Ling-juan Ruan; Juan-fen Mo

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Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition

中国医学科学杂志（英文版） 2013年28卷第3期页码：129-134

• 论著 • | Updated：2024-04-10

- Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition
- Affiliations：
  
  Key Laboratory, Jiaxing Second Hospital, Jiaxing University,Zhejiang,Jiaxing,China,314000
- Author bio：
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- 网络出版日期：2013-09-30，
  
  纸质出版日期：2013
- Accepted：
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Yi Bao, Ling-juan Ruan, Juan-fen Mo. Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition[J]. 中国医学科学杂志（英文版）, 2013,28(3):129-134.

Yi Bao, Ling-juan Ruan, Juan-fen Mo. Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition[J]. Chinese medical sciences journal, 2013, 28(3): 129-134.
Yi Bao, Ling-juan Ruan, Juan-fen Mo. Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition[J]. 中国医学科学杂志（英文版）, 2013,28(3):129-134. DOI：

Yi Bao, Ling-juan Ruan, Juan-fen Mo. Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition[J]. Chinese medical sciences journal, 2013, 28(3): 129-134. DOI：

摘要

Methods The transcripts of TRPS-1 and its role in survival in breast cancer were analyzed using published microarray data sets—Netherlands Cancer Institute (NKI) cohort and Wang cohort.Results TRPS-1 expression was lower in basal-like breast cancer. The mRNA levels of TRPS-1 negatively correlated with Slug (Pearson correlation coefficient=-0.1366

P=0.0189 in NKI data set and Pearson correlation coefficient=-0.1571

P=0.0078 in Wang data set)

FOXC1 (Pearson correlation coefficient=-0.1211

P=0.0376 in NKI data set and Pearson correlation coefficient=-0.1709

P=0.0037 in Wang data set)

and CXCL1 (Pearson correlation coefficient=-0.1197

P=0.0399 in NKI data set and Pearson correlation coefficient=-0.3436

P<0.0001 in Wang data set)

but positively correlated with BRCA1 (Pearson correlation coefficient=0.1728

P=0.0029 in NKI data set and Pearson correlation coefficient=0.1805

P=0.0022 in Wang data set). Low TRPS-1 expression associated with poor overall survival (hazard ratio 1.79

95% CI of ratio 0.9894 to 3.238

P=0.054) and relapse-free survival (hazard ratio 1.913

95% CI of ratio 1.159 to 3.156

P<0.05). The low TRPS-1 mRNA levels predicted poor outcome in breast cancer patients by the 70-gene signature.ConclusionThe strong expression of TRPS-1 may serve as a good prognostic marker in breast cancer.

Abstract

P=0.0189 in NKI data set and Pearson correlation coefficient=-0.1571

P=0.0078 in Wang data set)

FOXC1 (Pearson correlation coefficient=-0.1211

P=0.0376 in NKI data set and Pearson correlation coefficient=-0.1709

P=0.0037 in Wang data set)

and CXCL1 (Pearson correlation coefficient=-0.1197

P=0.0399 in NKI data set and Pearson correlation coefficient=-0.3436

P<0.0001 in Wang data set)

but positively correlated with BRCA1 (Pearson correlation coefficient=0.1728

P=0.0029 in NKI data set and Pearson correlation coefficient=0.1805

P=0.0022 in Wang data set). Low TRPS-1 expression associated with poor overall survival (hazard ratio 1.79

95% CI of ratio 0.9894 to 3.238

P=0.054) and relapse-free survival (hazard ratio 1.913

95% CI of ratio 1.159 to 3.156

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