Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly

Xiao-yan Xia; Xing-hua Huang; Yi-xin Xia; and Wei-hua Zhang

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Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly

中国医学科学杂志（英文版） 2011年第2期页码：109-112

• Original Article • | Updated：2024-04-10

- Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly
- Affiliations：
  
  1. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital , Capital Medical University,Beijing,China,100026
  2. Department of Obstetrics and Gynecology, General Hospital of Armed Police Forces,Beijing,China,100039
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2011-06-24，
  
  纸质出版日期：2011
- Accepted：
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Xiao-yan Xia, Xing-hua Huang, Yi-xin Xia, 等. Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly[J]. 中国医学科学杂志（英文版）, 2011,(2):109-112.

Xiao-yan Xia, Xing-hua Huang, Yi-xin Xia, et al. Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly[J]. Chinese medical sciences journal, 2011, (2): 109-112.
Xiao-yan Xia, Xing-hua Huang, Yi-xin Xia, 等. Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly[J]. 中国医学科学杂志（英文版）, 2011,(2):109-112. DOI：

Xiao-yan Xia, Xing-hua Huang, Yi-xin Xia, et al. Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly[J]. Chinese medical sciences journal, 2011, (2): 109-112. DOI：

摘要

Objective To detect the change of nerve growth factor (NGF) level in human amniotic fluid during gestation

and to explore the relationship between this change and fetal ventriculomegaly (VM). Methods The studied subjects (collected from 2004 to 2007) were divided into four groups

including the second-trimester pregnancy group (n=113)

third-trimester pregnancy group (n=110)

fetal cerebral VM group (n=12)

and healthy control group (n=12) which matched with the VM group in gestational weeks. The amniotic fluid specimens were obtained during amniocentesis or cesarean section. The NGF levels in amniotic fluid were detected with enzyme-linked immunosorbent assay. Results A significantly negative correlation was found between gestational age and the NGF level in amniotic fluid (r=−0.6149

P<0.0001). The NGF level in patients with fetal VM was significantly lower than that in healthy controls (33.95±29.24 pg/mL vs. 64.73±16.21 pg/mL

P=0.024). Conclusion NGF levels in amniotic fluid may be a sensitive marker for fetal VM.

Abstract

Objective To detect the change of nerve growth factor (NGF) level in human amniotic fluid during gestation

and to explore the relationship between this change and fetal ventriculomegaly (VM). Methods The studied subjects (collected from 2004 to 2007) were divided into four groups

including the second-trimester pregnancy group (n=113)

third-trimester pregnancy group (n=110)

fetal cerebral VM group (n=12)

P<0.0001). The NGF level in patients with fetal VM was significantly lower than that in healthy controls (33.95±29.24 pg/mL vs. 64.73±16.21 pg/mL

P=0.024). Conclusion NGF levels in amniotic fluid may be a sensitive marker for fetal VM.

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