Objective To investigate the independent risk factors of traumatic brain injury (TBI) prognosis. Methods A retrospective analysis was performed in 885 hospitalized TBI patients from January 1

2003 to January 1

2010 in the First Affiliated Hospital of Medical College of Xi’an Jiaotong University .Single-factor and logisticregression analysis were conducted to evaluate the association of different variables with TBI outcome. Results The single-factor analysis revealed significant association between several variables and TBI outcome

including age ( P=0.044 for the age group 40-60

P＜0.001 for the age group ≥60)

complications ( P<0.001)

cerebrospinal fluid leakage( P<0.001)

Glasgow Coma Scale(GCS) ( P<0.001)

pupillary light reflex ( P<0.001)

shock ( P<0.001)

associated extra-craniallesions ( P=0.01)

subdural hematoma ( P<0.001)

cerebral contusion ( P<0.001)

diffuse axonal injury ( P<0.001)

and subarachnoid hemorrhage( P<0.001)

suggesting theinfluence of those factors on the prognosis of TBI. Furthermore

logistic regression analysis identified age

GCS score

pupillary light reflex

subdural hematoma

and subarachnoid hemorrhage as independent risk factors of TBI prognosis. Conclusion Age

GCS score

papillary lightreflex

subdural hematoma

and subarachnoid hemorrhage may be risk factors influencing the prognosis of TBI. Paying attention to those factors might improve the outcome of TBI in clinical treatment.