Objective To evaluate the predictive factors of refractory glaucoma treated with diode laser transscleral cyclophotocoagulation (TSCP) in a midterm observation.  Methods Fifty-four consecutive patients (54 eyes) with refractory glaucoma were enrolled and underwent TSCP (power of 1.5-2.0 W

exposure time of 2 seconds and 20-50 applications). Patients were regularly followed up for 12 months. Intraocular pressure (IOP) was measured before TSCP treatment and at each follow-up visit. Patients were divided into the sensitive and insensitive groups according to the effect of a single treatment of TSCP on IOP. The success rate was defined as the percentage of eyes achieving an IOP between 5 and 21 mm Hg following TSCP therapy at their final follow up visit. Difference of age between the sensitive and insensitive groups was evaluated with Independent-samples T test and that of gender distribution of two groups was evaluated with Fisher’s exact test. The success rate of different types of glaucoma to TSCP was calculated.　  Results A total of 32 patients were sensitive to TSCP (sensitive group) and 22 patients were insensitive to TSCP (insensitive group). The success rates of female (77.8%

14/18) and cases being over 50 years (71.4%

20/28) were higher than those of male (50.0%

18/36) and ones being under 50 years (46.2%

12/26) (all P>0.05). The age of the sensitive and insensitive groups was 56.0±15.5 and 46.4±15.4 years

respectively (P=0.029). The age (P=0.029) and gender distribution (P=0.046) of the two groups had significant difference. The success rate of neovascular glaucoma

primary angle-closure glaucoma

primary open angle glaucoma

traumatic glaucoma

uveitic glaucoma

and secondary glaucoma after silicone oil injec-tion to TSCP was 57.1%

100.0%

50.0%

20.0%

81.8%

and 0%

respectively.  Conclusion Age

gender

and type of glaucoma appear to be associated with effect of TSCP on IOP control.