Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△

Bao-zhi Fang; Guang-sheng He; Hai-xia Zhou; Hui-rong Chang; De-pei Wu; Ai-ning Sun; and Su-ning Chen

Your Location：

Home >

Browse articles >

Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△

中国医学科学杂志（英文版） 2013年第1期页码：58-60

• Short Communication • | Updated：2024-04-10

- Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△
- Affiliations：
  
  1. Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University,Suzhou,China,215006
  2. ,China
  3. The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital),Suzhou,China,215002
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2013-03-26，
  
  纸质出版日期：2013
- Accepted：
Scan QR Code
Bao-zhi Fang, Guang-sheng He, Hai-xia Zhou, 等. Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△[J]. 中国医学科学杂志（英文版）, 2013,(1):58-60.

Bao-zhi Fang, Guang-sheng He, Hai-xia Zhou, et al. Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△[J]. Null, 2013, (1): 58-60.
Bao-zhi Fang, Guang-sheng He, Hai-xia Zhou, 等. Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△[J]. 中国医学科学杂志（英文版）, 2013,(1):58-60. DOI：

Bao-zhi Fang, Guang-sheng He, Hai-xia Zhou, et al. Three Times Spontaneous Remission of Severe Aplastic Anemia Following Granulocyte Transfusion from Related Donors: a Case Report and Literature Review△[J]. Null, 2013, (1): 58-60. DOI：

摘要

APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes

resulting in the apoptosis of hematopoietic cells and bone marrow failure.

Currently

hematopoietic stem cell transplantation (HSCT)

immunosuppressive - therapy (IST)

and supportive care (e.g. transfusion adjuvant therapy

hematopoietic growth factors

and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST.

This article reported a severe AA patient who failed to respond to IST

but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity

which might explain this patient’s recovery.

Abstract

APLASTIC anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes

resulting in the apoptosis of hematopoietic cells and bone marrow failure.

Currently

hematopoietic stem cell transplantation (HSCT)

immunosuppressive - therapy (IST)

and supportive care (e.g. transfusion adjuvant therapy

hematopoietic growth factors

and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST.

This article reported a severe AA patient who failed to respond to IST

which might explain this patient’s recovery.

关键词

Keywords

references

浏览量

1755

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

RELATIONSHIP BETWEEN HUMAN PARVOVIRUS B19 INFECTION AND APLASTIC ANEMIA