mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients

Yu-mei Li; Zhi-qiang Chen; Xu Yao; Ai-zhen Yang; An-sheng Li; Dong-ming Liu and Juan-qin Gong

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mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients

中国医学科学杂志（英文版） 2010年第3期页码：162-168

• Original Article • | Updated：2024-04-10

- mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients
- Affiliations：
  
  1. Department of Dermatology
  2. Department of Medical Imaging and Radiology,the Affiliated Hospital of Jiangsu University,Zhenjiang,China,212001
  3. Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College,Nanjing,China,210042
  4. Central Lab of People's Liberation Army Cancer Center, the 81st Military Hospital,Nanjing,China,210002
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2010-09-20，
  
  纸质出版日期：2010
- Accepted：
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Yu-mei Li, Zhi-qiang Chen, Xu Yao, 等. mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients[J]. 中国医学科学杂志（英文版）, 2010,(3):162-168.

Yu-mei Li, Zhi-qiang Chen, Xu Yao, et al. mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients[J]. Chinese medical sciences journal, 2010, (3): 162-168.
Yu-mei Li, Zhi-qiang Chen, Xu Yao, 等. mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients[J]. 中国医学科学杂志（英文版）, 2010,(3):162-168. DOI：

Yu-mei Li, Zhi-qiang Chen, Xu Yao, et al. mRNA Expression of Chemokine Receptors on Peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus Patients[J]. Chinese medical sciences journal, 2010, (3): 162-168. DOI：

摘要

Objective To investigate the expressions of chemokine receptors and interleukin (IL) receptors on the peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients and their correlations with clinical features as well as SLE disease activity index (SLEDAI). Methods The mRNA expressions of chemokine receptors and IL receptors on PBMCs of 93 SLE patients and 30 healthy controls were detected by reverse transcription-polymerase chain reaction

including CCR2

CCR3

CCR4

CCR5

CCR6

CCR8

CXCR3

CXCR5

CX3CR1

XCR1

IL-4R

and IL-10R. The clinical features of SLE patients were recorded. The correlations of chemokine receptors and IL receptors mRNA expressions with clinical features as well as SLEDAI were assayed using linear regression analysis. Results The level of CCR5 mRNA in SLE patients (including active and inactive SLE) was significantly higher than that in healthy controls (P<0.05)

and there was no significant difference between active and inactive patients in this respect (P>0.05). CX3CR1 mRNA expression significantly increased from healthy control to inactive SLE to active SLE in sequence. The others (except for CCR8

CXCR3

and IL-10R) in active SLE patients were significantly higher than those in both inactive SLE patients and healthy controls (all P<0.05). There were positive correlations between SLEDAI and CCR2 (r=0.424

t=4.313

P<0.001)

CCR3 (r=0.518

t=5.410

P<0.001)

CCR4 (r=0.376

t=3.851

P<0.001)

CCR6 (r=0.457

t=4.513

P<0.001)

CXCR5 (r=0.455

t=4.629

P<0.001)

CX3CR1 (r=0.445

t=4.523

P<0.001)

as well as XCR1 (r=0.540

t=5.445

P<0.001). And CCR5 mRNA expression level was positively correlated with IL-4R mRNA (r=0.313

t=2.353

P<0.05). The patients with myositis and cutaneous vasculitis simultaneously showed lower levels of CCR5 and CX3CR1

and CCR5 expression was negatively correlated with the scores of SLEDAI in SLE cases accompanied by photosensitivity (r=0.426

t=??2.155

P<0.05). Conclusion Increased expressions of CCR5 and CX3CR1 on PBMCs may be indicators in clinical survey for SLE.

Abstract

including CCR2

CCR3

CCR4

CCR5

CCR6

CCR8

CXCR3

CXCR5

CX3CR1

XCR1

IL-4R

CXCR3

t=4.313

P<0.001)

CCR3 (r=0.518

t=5.410

P<0.001)

CCR4 (r=0.376

t=3.851

P<0.001)

CCR6 (r=0.457

t=4.513

P<0.001)

CXCR5 (r=0.455

t=4.629

P<0.001)

CX3CR1 (r=0.445

t=4.523

P<0.001)

as well as XCR1 (r=0.540

t=5.445

P<0.001). And CCR5 mRNA expression level was positively correlated with IL-4R mRNA (r=0.313

t=2.353

P<0.05). The patients with myositis and cutaneous vasculitis simultaneously showed lower levels of CCR5 and CX3CR1

and CCR5 expression was negatively correlated with the scores of SLEDAI in SLE cases accompanied by photosensitivity (r=0.426

t=??2.155

P<0.05). Conclusion Increased expressions of CCR5 and CX3CR1 on PBMCs may be indicators in clinical survey for SLE.

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