Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery

Zhi-jian Sun; Yu Zhao; Giu-xing Qiu; Yi-peng Wang; Xi-sheng Weng; Hong Zhao etc.

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Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery

中国医学科学杂志（英文版） 2011年第4期页码：221-226

• Original Article • | Updated：2024-04-10

- Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery
- Affiliations：
  
  Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China,100730
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2011-12-30，
  
  纸质出版日期：2011
- Accepted：
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Zhi-jian Sun, Yu Zhao, Giu-xing Qiu, 等. Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery[J]. 中国医学科学杂志（英文版）, 2011,(4):221-226.

Zhi-jian Sun, Yu Zhao, Giu-xing Qiu, et al. Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery[J]. Chinese medical sciences journal, 2011, (4): 221-226.
Zhi-jian Sun, Yu Zhao, Giu-xing Qiu, 等. Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery[J]. 中国医学科学杂志（英文版）, 2011,(4):221-226. DOI：

Zhi-jian Sun, Yu Zhao, Giu-xing Qiu, et al. Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery[J]. Chinese medical sciences journal, 2011, (4): 221-226. DOI：

摘要

Objective To evaluate the efficacy and safety of low molecular weight heparin (LMWH) prophylaxis for venous thromboembolism (VTE) after lumbar decompression surgery. Methods Patients at high or the highest risk of VTE who underwent lumbar spine surgery in Peking Union Medical College Hospital from January 2004 to April 2011 were included in the present study. All the patients received a half dose of LMWH 6 hours after surgery followed by a full dose LMWH once per day until discharge. We recorded incidences of deep venous thrombosis (DVT)

pulmonary embolism (PE)

bleeding complications

and medication side effects. Results Seventy-eight consecutive patients were eligible and enrolled in this study. The mean hospital stat was 8.5±4.5 days. No symptomatic DVT

or major bleeding events were observed. One patient developed wound ecchymosis

another developed wound bleeding

four had mild hepatic aminotransferase level elevation

and one developed a suspicious allergic reaction. Conclusion LMWH may be applied as an effective and safe prophylaxis for VTE in high-risk patients undergoing lumbar decompression surgery.

Abstract

pulmonary embolism (PE)

bleeding complications

and medication side effects. Results Seventy-eight consecutive patients were eligible and enrolled in this study. The mean hospital stat was 8.5±4.5 days. No symptomatic DVT

or major bleeding events were observed. One patient developed wound ecchymosis

another developed wound bleeding

four had mild hepatic aminotransferase level elevation

and one developed a suspicious allergic reaction. Conclusion LMWH may be applied as an effective and safe prophylaxis for VTE in high-risk patients undergoing lumbar decompression surgery.

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