Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy

Xiao-liang Xing; Long-ze Sha; Yuan Yao; Yan Shen; Li-wen Wu; and Qi Xu

Your Location：

Home >

Browse articles >

Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy

中国医学科学杂志（英文版） 2012年第1期页码：7-10

• Original Article • | Updated：2024-04-10

- Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy
- Affiliations：
  
  1 National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100005, China 2 Department of Neurology, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China,100730
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2012-03-30，
  
  纸质出版日期：2012
- Accepted：
Scan QR Code
Xiao-liang Xing, Long-ze Sha, Yuan Yao, 等. Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy[J]. 中国医学科学杂志（英文版）, 2012,(1):7-10.

Xiao-liang Xing, Long-ze Sha, Yuan Yao, et al. Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy[J]. Chinese medical sciences journal, 2012, (1): 7-10.
Xiao-liang Xing, Long-ze Sha, Yuan Yao, 等. Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy[J]. 中国医学科学杂志（英文版）, 2012,(1):7-10. DOI：

Xiao-liang Xing, Long-ze Sha, Yuan Yao, et al. Spatio-temporal Expression Study of Phosphorylated 70-kDa Ribosomal S6 Kinase (p70S6k) in Mesial Temporal Lobe Epilepsy[J]. Chinese medical sciences journal, 2012, (1): 7-10. DOI：

摘要

ObjectiveTo determine the spatio-temporal expression of p70S6k activation in hippocampus in mesial temporal lobe epilepsy. Methods Temporal lobe epilepsy model was established by stereotaxically unilateral and intrahippocampal injection of kainite acid (KA) in adult male C57BL/6 mice. Latent and chronic epileptogenesis were represented by mice 5 days after KA injection ( n=5) and mice 5 weeks after KA injection ( n=8)

respectively. Control mice ( n=5) were injected with saline. Immunohistochemical assays were performed on brain sections of the mice. Results Hippocampus both ipsilateral and contralateral to the KA injection displayed significantly up-regulated pS6 immunoreactivity in dispersed granule cells in 5-day and 5-week model mice. Conclusion The activation of p70S6k is mainly located in the dentate gyrus in KA-induced mouse model of temporal lobe epilepsy

indicating that the activation may be related with the disperse degree and hypertrophy of granule cells.

Abstract

indicating that the activation may be related with the disperse degree and hypertrophy of granule cells.

关键词

Keywords

references

浏览量

2643

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据