Propofol Affects Different Human Brain Regions Depending on Depth of Sedation

Quan Xiang; Ye* Tie-hu; Lin Si-fang; Zou Liang; Tian Shou-yuan

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Propofol Affects Different Human Brain Regions Depending on Depth of Sedation

中国医学科学杂志（英文版） 2015年30卷第3期页码：135-142

Orginal Article | Updated：2024-04-10

- Propofol Affects Different Human Brain Regions Depending on Depth of Sedation
- Affiliations：
  
  Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
- Funds：
  
  △Supported by National Natural Science Foundation of China (30672030).
- DOI：
  中图分类号：
- 网络出版日期：2015-06-20，
  
  纸质出版日期：2015-06
- Accepted：
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Propofol Affects Different Human Brain Regions Depending on Depth of Sedation[J]. 中国医学科学杂志（英文版）, 2015,30(3):135-142.

Quan Xiang, Ye* Tie-hu, Lin Si-fang, et al. Propofol Affects Different Human Brain Regions Depending on Depth of Sedation^△[J]. Chinese medical sciences journal, 2015, 30(3): 135-142.
Propofol Affects Different Human Brain Regions Depending on Depth of Sedation[J]. 中国医学科学杂志（英文版）, 2015,30(3):135-142. DOI：

Quan Xiang, Ye* Tie-hu, Lin Si-fang, et al. Propofol Affects Different Human Brain Regions Depending on Depth of Sedation^△[J]. Chinese medical sciences journal, 2015, 30(3): 135-142. DOI：

摘要

Abstract

Objective

To investigate the effect of propofol on brain regions at different sedation levels and the association between changes in brain region activity and loss of consciousness using blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) and bispectral index (BIS) monitoring.

Methods

Forty-eight participants were enrolled at Peking Union Medical College Hospital from October 2011 to March 2012 and randomly assigned to a mild or a deep sedation group using computer- generated random numbers. Preliminary tests were performed a week prior to scanning to determine target effect site concentrations based on BIS and concomitant Observer’s Assessment of Alertness/Sedation scores while under propofol. Within one week of the preliminary tests where propofol dose-response was established

BOLD-fMRI was conducted to examine brain activation with the subject awake

and with propofol infusion at the sedation level.

Results

Mild propofol sedation inhibited left inferior parietal lobe activation. Deep sedation inhibited activation of the left insula

left superior temporal gyrus

and right middle temporal gyrus. Compared with mild sedation

deep propofol sedation inhibited activation of the left thalamus

precentral gyrus

anterior cingulate

and right basal nuclei.

Conclusion

Mild and deep propofol sedation are associated with inhibition of different brain regions

possibly explaining differences in the respective loss of consciousness processes.

关键词

Keywords

references

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