Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody<sup>△</sup>

Hong-bo Yang; Wen-jie Zheng; Xuan Zhang; Fu-lin Tang

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Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody^△

中国医学科学杂志（英文版） 2011年第3期页码：152-157

• Original Article • | Updated：2024-04-10

- Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody^△
- Affiliations：
  
  1. Department of Endocrinology
  2. Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China,100730
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 网络出版日期：2011-09-24，
  
  纸质出版日期：2011
- Accepted：
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Hong-bo Yang, Wen-jie Zheng, Xuan Zhang, 等. Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody^△[J]. 中国医学科学杂志（英文版）, 2011,(3):152-157.

Hong-bo Yang, Wen-jie Zheng, Xuan Zhang, et al. Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody[J]. Chinese medical sciences journal, 2011, (3): 152-157.
Hong-bo Yang, Wen-jie Zheng, Xuan Zhang, 等. Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody^△[J]. 中国医学科学杂志（英文版）, 2011,(3):152-157. DOI：

Hong-bo Yang, Wen-jie Zheng, Xuan Zhang, et al. Induction of Endothelial Cell Apoptosis by Anti-alpha-enolase Antibody[J]. Chinese medical sciences journal, 2011, (3): 152-157. DOI：

摘要

Objective To assess the prevalence of anti-alpha-enolase antibody in systemic autoimmune diseases in Chinese patients and its role in endothelial cell apoptosis. Methods The reactivity of anti-alpha-enolase antibody in a variety of autoimmune disorders in Chinese patients was evaluated by dot blot assay. Endothelial cell apoptosis was investigated by in vitro incubation of endothelial cells with IgG purified from anti-alpha-enolase antibody-positive sera

with or without pre-incubation with recombinant alpha-enolase. Results Anti-alpha-enolase antibody was prevalent in different systemic autoimmune diseases with relatively high reactivity in Chinese patients. In vitro incubation of endothelial cells with IgG containing anti-alpha-enolase antibody induced apoptosis in a time- and dose-dependent manner. Apoptosis was partly inhibited by pre-incubation of the endothelial cells with recombinant alpha-enolase. Conclusions Our data suggest that alpha-enolase is a common auto-antigen recognized by anti- endothelial cell antibodies in connective tissue disease. Interaction between alpha-enolase and its autoantibody plays a role in endothelial cell apoptosis. Changes other than cell killing may contribute to the pathogenesis of endothelial damage and microvascular lesions.

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