Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials<sup>△</sup>

Jiang Can; Zheng Dong; Feng Yun-lu; Guo* Jun; Li Hai-rui; Zhang Ai-dong

Your Location：

Home >

Browse articles >

Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials^△

中国医学科学杂志（英文版） 2016年31卷第3期页码：142-148

Orginal Article | Updated：2024-04-10

- Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials^△
- Affiliations：
  
  Department of Cardiology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
- Author bio：
- Funds：
  
  △Supported by the Youth Project of National Natural Science Foundation (81100078) , the Key Project of Chinese Ministry of Education (211207), Guangzhou Pearl River science and technology new star project plan (2012J2200063) and Project of Guangdong Science and Technology Department (S2011040001392).
- DOI：
  中图分类号：
- 网络出版日期：2016-06-20，
  
  纸质出版日期：2016-06
- Accepted：
Scan QR Code
Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials^△[J]. 中国医学科学杂志（英文版）, 2016,31(3):142-148.

Jiang Can, Zheng Dong, Feng Yun-lu, et al. Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials^△[J]. Chinese medical sciences journal, 2016, 31(3): 142-148.
Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials^△[J]. 中国医学科学杂志（英文版）, 2016,31(3):142-148. DOI：

Jiang Can, Zheng Dong, Feng Yun-lu, et al. Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials^△[J]. Chinese medical sciences journal, 2016, 31(3): 142-148. DOI：

摘要

Abstract

Objective

To investigate the short- and long-term therapeutic efficacies of intravenous trans- plantation of bone marrow stem cells (MSCs) in rats with experimental myocardial infarction by meta- analysis.

Methods

Randomized controlled trials were systematically searched from PubMed

Science Citation Index (SCI)

Chinese journal full-text database (CJFD) up to December 2014. While the experimental groups (MSCs groups) were injected MSCs intravenously

the control groups were injected Delubecco’s minimum essential medium (DMEM) or phosphate buffered saline (PBS). Subgroup analysis for each outcome measure was performed for the observing time point after the transplantation of MSCs. Weighted mean differences (WMD) and 95% confidence intervals (

) were calculated for outcome parameters including ejection fraction (EF) and fractional shortening (FS)

which were measured by echocardiogram after intravenous injection and analyzed by RevMan 5.2 and STATA 12.0.

Results

Data from 9 studies (190 rats) were included in the meta-analysis. As compared to the control groups

the cardiac function of the experimental groups were not improved at day 7 (EF: WMD=0.08

95%

-1.32 to 1.16

0.01; FS: WMD=-0.12

95%

-0.90 to 0.65

0.01) until at day 14 after MSCs’ transplantation (EF: WMD=10.79

95%

9.16 to 12.42

0.01; FS: WMD=11.34

95%

10.44 to 12.23

0.01)

and it lasted 4 weeks or more after transplantation of MSCs (EF: WMD=13.94

95%

12.24 to 15.64

0.01; FS: WMD=9.64

95%

7.98 to 11.31

0.01).

Conclusion

The therapeutic efficacies of MSCs in rats with myocardid infarction become increasing apparent as time advances since 2 weeks after injection.

关键词

Keywords

references

Chi NH , Yang MC , Chung TW , et al. Cardiac repair achieved by bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid patches in a rat of myocardial infarction model. Biomaterials 2012 ; 33 : 5541 - 51 .

Wang JA , Fan YQ , Li CL , et al. Human bone marrow-derived mesenchymal stem cells transplanted into damaged rabbit heart to improve heart function. J Zhejiang Univ Sci B 2005 ; 6 : 242 - 8 .

Hou M , Yang KM , Zhang H , et al. Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats. Int J Cardiol 2007 ; 115 : 220 - 8 .

Peng C , Yang K , Xiang P , et al. Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarction. Int J Cardiol 2013 ; 162 : 158 - 65 .

Bian S , Zhang L , Duan L , et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl) 2014 ; 92 : 387 - 97 .

Houtgraaf JH , de Jong R , Kazemi K , et al . Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function. Circ Res 2013 ; 113 : 153 - 66 .

Nagaya N , Fujii T , Iwase T , et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 2004 ; 287 : H2670 - 6 .

Zuo S , Jones WK , Li H , et al. Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury. Stem Cells Dev 2012 ; 21 : 598 - 608 .

Li Z , Guo J , Chang Q , et al. Paracrine role for mesenchymal stem cells in acute myocardial infarction. Biol Pharm Bull 2009 ; 32 : 1343 - 6 .

Dai W , Hale SL , Kloner RA. Role of a paracrine action of mesenchymal stem cells in the improvement of left ventricular function after coronary artery occlusion in rats. Regen Med 2007 ; 2 : 63 - 8 .

Arias T , Chen J , Fayad ZA , et al. Comparison of echocardiographic measurements of left ventricular volumes to full volume magnetic resonance imaging in normal and diseased rats. J Am Soc Echocardiogr 2013 ; 26 : 910 - 8 .

Holinski S , Knebel F , Heinze G , et al. Noninvasive monitoring of cardiac function in a chronic ischemic heart failure model in the rat: assessment with tissue Doppler and non-Doppler 2D strain echocardiography. Cardiovasc Ultrasound 2011 ; 9 : 15 .

Zhang M , Mal N , Kiedrowski M , et al. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J 2007 ; 21 : 3197 - 207 .

Ma J , Ge J , Zhang S , et al. Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res Cardiol 2005 ; 100 : 217 - 23 .

Xing JL , Xu YB , Zhang Y , et al. Transplantation of Y chromosome labeled bone marrow-derived mesenchymal stem cells into rat hearts with myocardial infarction. J Shandong Univ (Health Sci) 2011 ; 49 : 74 - 7 .

Zhang RH , Li WM , Jing L , et al. Effects of bone mesenchymal stem cell transplantations via different routes on cardiac function of rats with acute myocardial infarction. Chin J Clin Rehabil 2006 ; 10 : 34 - 6

Jia M , Lu PQ , Feng R , et al. Comparison of different bone marrow mesenchymal cell transplantation methods for improving heart function after acute myocardial infarction. J Clin Rehabil Tissue Eng Res 2007 ; 11 : 2068 - 71

Wei YD , Xu YW , Chen YQ , et al. Experimental study of different transplanting ways of derived bone marrow mesenchymal stem cells in treating acute myocardial infarction. J Tongji Univ (Med Sci) 2008 ; 4 : 13 - 6 .

Li Y , Yao Y , Sheng Z , et al. Dual-modal tracking of transplanted mesenchymal stem cells after myocardial infarction. Int J Nanomedicine 2011 ; 6 : 815 - 23 .

Zhao LS , Du YY , Jiao KL , et al. Study on treating of acute myocardial infarction by intravenously delivering mesen- chymal stem cells in rats. J Zhengzhou Univ (Med Sci) 2005 ; 2 : 313 - 6 .

Hou J , Wang L , Jiang J , et al. Cardiac stem cells and their roles in myocardial infarction. Stem Cell Rev 2013 ; 9 : 326 - 38 .

Vertesaljai M , Piroth Z , Fontos G , et al. Stem cell therapy in cardiovascular diseases. Orv Hetil 2005 ; 146 : 2383 - 8 .

Scorsin M , Hagege A , Vilquin JT , et al. Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function. J Thorac Cardiovasc Surg 2000 ; 119 : 1169 - 75 .

Jalil RA , Neng LC , Kofidis T. Challenges in deriving and utilizing stem cell-derived endothelial cells for regener- ative medicine: a key issue in clinical therapeutic appli- cations. J Stem Cells 2011 ; 6 : 93 - 9 .

Li RK , Mickle DA , Weisel RD , et al. Natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue. Circulation 1997 ; 96:II-179-86 ; discussion 186 - 7 .

Pittenger MF , Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004 ; 95 : 9 - 20 .

Hass R , Kasper C , Bohm S , et al. Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal 2011 ; 9 : 12 .

Bartolucci J , Verdugo FJ , Larrea R , et al. Stem cells for the treatment of cardiovascular diseases. An update. Rev Med Chil 2014 ; 142 : 1034 - 46 .

Lalu MM , McIntyre L , Pugliese C , et al . Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One 2012 ; 7 : e47559 .

Wang W , Jiang Q , Zhang H , et al. Intravenous adminis- tration of bone marrow mesenchymal stromal cells is safe for the lung in a chronic myocardial infarction model. Regen Med 2011 ; 6 : 179 - 90 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

Effects of Lianhua Qingwen on Pulmonary Oxidative Lesions Induced by Fine Particulates (PM2.5) in Rats