Objective To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease（CAD）.Methods The subjects were recruited from five independent cardiovascular centers.Coronary angiography was employed to define the CAD with stenosis in each major vessel ≥70% and control with stenosis <10% in every lesion.The classic risk factors including family history

body mass index

smoking habits

hypertension

diabetes mellitus

and serum lipid levels were surveyed according to established criteria.Associations between risk levels and clinical phenotypes were assessed by case control and correlation analysis.Results A total of 762 individuals were collected

including 481 men and 281 women

aged from 17 to 81（mean 60±10） years.The patients with CAD accounted for 55.5% of all participants

and controls 44.5%

respectively.Compared with the pattern in published data

our study showed that mean serum high density lipoprotein cholesterol（HDL-C） level was significantly lower（P<0.001） and triglycerides was significantly higher（P<0.001）

while total cholesterol（TC） and low density lipoprotein cholesterol levels were comparative（both P>0.05）.The prevalence of low HDL-C（<40 g/L） and hypertriglyceridemia（>150 g/L） were 27.2% and 41.4%

respectively.Mean serum levels of HDL-C and apolipoprotein A1 were significantly higher in female subjects than in male（P<0.001）.Lower HDL-C functioned as an independent risk factor for CAD only in men（RR=2.8

95%CI:1.5-4.2

P<0.001）

yet increased non-HDL cholesterol combined with diabetes mellitus and obesity seemed to play a key role in the development ofCAD in women.Similarity in risk association with CAD was found for hypertension and TC/HDL ratio in male and female subjects

while family history had no relationship with the presence of CAD.Conclusion It is remarkable that emphasis of intervention in future should be given on the prevalent low serum HDL-C and its strong risk correlation with the presence of CAD in male subjects of Chinese Han population.