Objective To study the therapeutical effects of crossing anastomosis of nerve on the peripheral and central nerve injuries. Methods Twelve kinds of central and peripheral nerve disorders and their complications were treated with 11 kinds of crossing anastomosis of nerve bundles near the innervated organs. After nerve injury and repair

somatosensory evoked potentials （SEPs） and horseradish peroxidase （HRP） retrograde tracing studies were used to investigate the rabbit’s nerve function and morphology. Results The ulcers of all patients healed. Sensation

voluntary movement

and joint function recovered. Four weeks after the anastomosis of distal stump of radialis superficialis nerve and median nerve

pain sensation regained and SEPs appeared. HRP retrograde tracing studies demonstrated sensory nerve ending of medial nerve formed new connection with the body of neuron. Conclusion Crossing anastomosis of nerve is an effective method to treat peripheral and central nerve injuries.