EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION

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EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION

中国医学科学杂志（英文版） 2006年0卷第3期页码：184-188

Updated：2024-04-10

- EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION
- Affiliations：
- Author bio：
- Funds：
  
  Supportedby the Early-stage Special FundforImportant Basis Research Projectfrom the Technology Department of China(2002CCAO4400)
- DOI：
  中图分类号： R363
- 纸质出版日期：2006
- Accepted：
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EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION[J]. 中国医学科学杂志（英文版）, 2006,0(3):184-188.

EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION[J]. Chinese medical sciences journal, 2006, 0(3): 184-188.
EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION[J]. 中国医学科学杂志（英文版）, 2006,0(3):184-188. DOI：

EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION[J]. Chinese medical sciences journal, 2006, 0(3): 184-188. DOI：

摘要

Abstract

Objective To investigate whether there is endogenous neural stem cell proliferation and whether these proliferated neural stem cells represent neural plasticity in the adult rats after cerebral infarction.Methods Cerebral infarction models of rats were established and the dynamic expression of bromodeoxyuridine （BrdU）

BrdU/polysialylated neural cell adhesion molecule （PSA-NCAM） were determined by immunohistochemistry and immunofluorescence staining. BrdU was used to mark dividing neural stem cells. PSA-NCAM was used to mark the plasticity of neural stem cells.Results Compared with controls

the number of BrdU-positive cells in the subventricular zone （SVZ） and hippocampus increased significantly at 1[KG-*3]st day after cerebral infarction （P<0.05）

reached maximum at 7th day

decreased markedly at 14th day

but it was still elevated compared with that of the controls （P<0.05）. The number of BrdU-labeled with PSA-NCAM-positive cells increased significantly at 7th day （P<0.05）

reached maximum at 14th day

markedly decreased at 28th day

but it was still elevated compared with that of the controls （P<0.05）. It was equal to 60% of the number of BrdU-positive cells in the same period.Conclusion Cerebral infarction may stimulate the proliferation of endogenous neural stem cells in situ and most proliferated neural stem cells represent neural plasticity.

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