Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing. Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years

salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years. Results After 5 years

the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teena-gers with salt sensitivity on the baseline

both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers （12.7±12.1 mmHg vs. 2.8 ±5.2 mmHg

P< 0.01; 12.2% ±12.0% vs. 2.5% ±4.4%

P< 0.001

respectively）. There was a similar trend for diastolic blood pressure （8.4 ±6.4 mmHg vs. 3.7 ±6.4 mmHg

P= 0.052; 13.2% ±10.6 % vs. 6.8% ±10.1%

P= 0.053

respectively）. Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers

especially in terms of systolic blood pressure.